Accomplishments

• EURAT Position Paper (Cornerstones for an ethically and legally informed practice of Whole Genome Sequencing: Code of Conduct and patient consent models)
• Guideline for advanced care planning and limiting treatment on changing and communicating the goal of care from curative to palliative
• Ongoing Interdisciplinary seminar series about ethical conflicts in decision- making (in Collaboration with the Department of Hematology/Oncology, Radiation Therapy, Theology, Psychology)
• Establishment of a working group “Medicine and Ethics” at the German Society for Hematology and Oncology
• Recommendations for a best practice of the release of genomic raw data to patients and research participants (in German only): Ausführliche Darstellung einer Empfehlung für ein mehrstufiges Verfahren zum Umgang mit Anfragen von Patienten und Probanden bezüglich einer Herausgabe ihrer genetischen Rohdaten

1. Clinical Ethics

• Laryionava K., Heußner P., Hiddemann W., Winkler E.C., “”Rather one more chemo than one less…”: Oncologists and Oncology Nurses’ Reasons for Aggressive Treatment of Young Adults with Advanced Cancer“, The Oncologist, 2018. Feb;23(2):256-262. doi: 10.1634/theoncologist.2017-0094.
• Mehlis K., Winkler E.C., “Ethische Analyse lebensverlängernder Behandlungen. Zum Schutz der Selbstbestimmung und zum Schutz vor Übertherapie”, Der Onkologe, 2016. 22(11):844-851.
• Winkler E.C., Hiddemann W., Marckmann, G., “Evaluating a patient’s request for life-prolonging treatment: An ethical decision aid”, Lancet Oncology, Aug 2011, Vol 11, 720-22.
• Winkler E.C., Reiter-Theil S., Lange-Rieß D., Schmal-Menges N., Hiddemann, W., „Patient involvement in decisions to limit treatment: the crucial role of agreement between physician and patient.“, J Clin Oncol, 2009 (27): 2225-2230.
• Mehlis K, Bierwirth E,  Laryionava K, Mumm FH, Hiddemann W, Heußner P, Winkler EC (2018). „High prevalence of moral distress reported by oncologists and oncology nurses in end-of-life decision making” Psycho-Oncology. doi: 10.1002/pon.4868.
• Laryionava K, Mehlis K, Bierwirth E, Mumm FHA, Hiddemann W, Heußner P, Winkler EC (2018). “Development and Evaluation of an Ethical Guideline for Decisions to Limit Life-Prolonging Treatment in Advanced Cancer: Protocol for a Monocentric Mixed-Method Interventional Study” JMIR Res Protoc 2018 Jun 15;7(6):e157.
• Mehlis K, Becker C, Christ C, Laryionava K, Hiddemann W, Heußner P, Winkler EC (2017). „Entscheidungspraxis zur Therapiebegrenzung (TBE) am Lebensende in der hämatologisch/ onkologischen Universitätsklinik. Empirische Baseline-Erhebung der leitliniengestützten Interventionsstudie zur Verbesserung von Entscheidungen zur Therapiebegrenzung“ Dtsch Med Wochenschr 2017; 142: 116-123.

2. Research Ethics

• Schleidgen S., Husedzinovic A., Ose D., Schickhardt C., von Kalle C., Winkler EC., “Between Minimal and Greater than Minimal Risk: How Research Participants and Oncologists Assess Data-Sharing and the Risk of Re-Identification in Genomic Research”, Philosophy & Technology, 2017, 1-17.
• Schuol S., Schickhardt C., Wiemann S., Bartram C.R., Tanner K., Eils R., Meder B., Richter D., Glimm H., v. Kalle C., Winkler E.C., „So rare we need to hunt for them. Reframing the ethical debate on incidental findings”, Genome Medicine, 2015. 7(1): 83.
• Fleischer H., Schickhardt C., Taupitz J., Winkler E.C., „Das Recht von Patienten und Probanden auf Herausgabe ihrer genetischen Rohdaten. Eine rechtliche und ethische Analyse samt einer Empfehlung für die  Praxis“,  Medizinrecht, 2016. 34(7): 481-491.
• Wiemann S., Winkler E.C., „Findings made in gene panel to whole genome sequencing: data, knowledge, ethics – and consequences?”, Expert Review of Molecular Diagnostics,  2016. 16(12): 1259-1270.

3. Health Policy

• Mehlis K, Woydack L, Winkler EC (2019). „Klinikkodizes als Korrektiv im ärztlichen Alltag?“ Med Klin Intensivmed Notfmed 2019 May 10, doi: 10.1007/s00063-019-0587-2.
• Witte J, Mehlis K, Surmann B, Lingnau R, Damm O, Greiner W, Winkler EC (2019). “Methods for measuring financial toxicity after cancer diagnosis and treatment: a systematic review and its implications” Ann Oncol. 2019 May 2. pii: mdz140. doi: 10.1093/annonc/mdz140
• Fernau S., Mehlis K., Schildmann J., Krause S., Winkler E.C., „The Role of Physicians in Rationing Cancer Care. Attitudes of German Oncologists.”, Oncol Res Treat, 2017. 40(9):490-494. doi: 10.1159/000475759.
• Krause S.W., Schildmann J., Lotze Ch., Winkler E.C., "Rationing Cancer Care: A Survey Among the Members of the German Society of Hematology and Oncology" J NatlComprCancNetw 2013;11:658-665.

• German CancerAid - Deutsche Krebshilfe e.V.
• German Ministryfor Education and Research (Bundesministerium für Bildung und Forschung)
• Early Clinical development Research (DKFZ)
• Marsilius-Kolleg (Initiative of Excellence)
• Deutsche Forschungsgemeinschaft e.V. (DFG)

• Walter Siegenthaler Preis 2017 der Deutschen Medizinischen Wochenschrift (5.000 €):
  Mehlis K, Becker C, Christ C, Laryionava K, Hiddemann W, Heußner P, Winkler EC. „Entscheidungspraxis zur Therapiebegrenzung (TBE) am Lebensende in der hämatologisch/ onkologischen Universitätsklinik. Empirische Baseline-Erhebung der leitliniengestützten Interventionsstudie zur Verbesserung von Entscheidungen zur Therapiebegrenzung“
• Lohfert Prize 2016 (20.000 €) for the EPAL-project: Heußner P, Winkler EC. “Treatment limitation: improvement of shared decision-making with cancer patients“
  » Lohfert-Preis 2016: Portrait des Preisträgers (YouTube)
• Best Poster Award: Laryionava K, Sklenarova H, Heußner P, Hartmann M, Winkler EC. “Decision Making in Oncology at the End of Life: Patient’s Preferences for Quality or Length of Life.” Ethics and Evidence in end-of-life decision making - Interdisciplinary Perspectives. 3. -4. April 2014, Bochum, Deutschland
• Roche Faculty Award (10.000 SFR) for the best dissertation 2010, University of Basel, Switzerland: Winkler EC. “Challenges at the End of Life: Involving Patients and Family Members in Decisions Concerning the Determination of Medical Care”