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Springfeld C, Wiecha C, Kunzmann R, Heger U, Weichert W, Langer R, Stange A, Blank S, Sisic L, Schmidt T, Lordick F, Jäger D, Grenacher L, Bruckner T, Büchler MW, Ott K. Influence of Different Neoadjuvant Chemotherapy Regimens on Response, Prognosis, and Complication Rate in Patients with Esophagogastric Adenocarcinoma. Ann Surg Oncol. 2015;22 Suppl 3:S905-14.
Staffa L, Echterdiek F, Nelius N, Benner A, Werft W, Lahrmann B, Grabe N, Schneider M, Tariverdian M, Doeberitz MV, Blaker H, Kloor M. Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome - Molecular Alterations and Association with Clinical Parameters. Plos One. 2015;10(3).
Steindorf K, Clauss D, Wiskemann J, Schmidt ME. Physical Activity and Gastrointestinal Cancers: Primary and Tertiary Preventive Effects and Possible Biological Mechanisms. Sports. 2015;3(3):145-148.
Tauchert FK, Bankstahl US, Winkler EC, Hofheinz R, Marschner N, Quidde J, Hipp M, Hoeffkes HG, Weber M, Trojan J, Van Kampen M, Brueckl WM, Jaeger E, Al-Batran SE, Grp AQW. Changing symptom burden in cancer patients: Does physician-patient communication cover physical, psychological and social discomfort? A Survey among 2009 German patients. J Clin Oncol. 2015;33(15).
Teichgräber V, Monasterio C, Chaitanya K, Boger R, Gordon K, Dieterle T, Jäger D, Bauer S. Specific inhibition of fibroblast activation protein (FAP)-alpha prevents tumor progression in vitro. Adv Med Sci. 2015;60(2):264-272.
Theile D, Allendorf D, Köhler BC, Jassowicz A, Weiss J. Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines. J Pharm Pharmacol. 2015;67(11):1575-84.
Ungar N, Sieverding M, Ulrich CM, Wiskemann J. What explains the intention to be physically active in cancer patients? Different determinants for active and insufficiently active patients. Journal of psychosocial oncology. 2015;33(1):15-33.
Vallet S, Pahernik S, Höfner T, Tosev G, Hadaschik B, Duensing S, Sedlaczek O, Hohenfellner M, Jäger D, Grüllich C, NCT NCTD. Efficacy of Targeted Treatment Beyond Third-Line Therapy in Metastatic Kidney Cancer: Retrospective Analysis From a Large-Volume Cancer Center. Clin Genitourin Canc. 2015;13(3):E145-E152.
Vogel A, Kasper S, Weichert W, Bitzer M, Block A, Riess H, Schulze-Bergkamen H, Moehler MH, Merx KE, Endris V, Schnoy E, Siveke JT, Michl P, Waldschmidt D, Kuhlmann J, Geissler M, Kahl C, Kubicka S. Panitumumab in combination with gemcitabine/cisplatin (GemCis) for patients with advanced kRAS WT biliary tract cancer: A randomized phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO). J Clin Oncol. 2015;33(15).
Vogel A, Kullmann F, Kunzmann V, Riess H, Al-Batran SE, Oettle H, Plentz R, Siveke J, Springfeld C. Patients with Advanced Pancreatic Cancer and Hyperbilirubinaemia: Review and German Expert Opinion on Treatment with nab-Paclitaxel plus Gemcitabine. Oncol Res Treat. 2015;38(11):596-603.
Waldera Lupa DM, Kalfalah F, Safferling K, Boukamp P, Poschmann G, Volpi E, Gotz-Rosch C, Bernerd F, Haag L, Huebenthal U, Fritsche E, Boege F, Grabe N, Tigges J, Stuhler K, Krutmann J. Characterization of Skin Aging-Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin. J Invest Dermatol. 2015;135(8):1954-68.
Wang L, Jin N, Schmitt A, Greiner J, Malcherek G, Hundemer M, Mani J, Hose D, Raab MS, Ho AD, Chen BA, Goldschmidt H, Schmitt M. T cell-based targeted immunotherapies for patients with multiple myeloma. Int J Cancer. 2015;136(8):1751-68.
Weber T, Mavratzas A, Kiesgen S, Haase S, Botticher B, Exner E, Mier W, Grosse-Hovest L, Jäger D, Arndt MA, Krauss J. A Humanized Anti-CD22-Onconase Antibody-Drug Conjugate Mediates Highly Potent Destruction of Targeted Tumor Cells. Journal of immunology research. 2015;2015:561814.
Weinhold N, Kirn D, Seckinger A, Hielscher T, Granzow M, Bertsch U, Egerer G, Salwender H, Blau IW, Weisel K, Hillengass J, Raab MS, Hose D, Goldschmidt H, Jauch A. Concomitant gain of 1q21 and MYC translocation define a poor prognostic subgroup of hyperdiploid multiple myeloma. Haematologica. 2015;101(3):e116-9.
Weinmann A, Koch S, Sprinzl M, Kloeckner R, Schulze-Bergkamen H, Duber C, Lang HK, Otto G, Worns MA, Galle PR. Survival analysis of proposed BCLC-B subgroups in hepatocellular carcinoma patients. Liver Int. 2015;35(2):591-600.
Weinmann A, Sattler T, Unold HP, Grambihler A, Teufel A, Koch S, Schuchmann M, Biesterfeld S, Worns MA, Galle PR, Schulze-Bergkamen H. Predictive Scores in Primary Biliary Cirrhosis A Retrospective Single Center Analysis of 204 Patients. J Clin Gastroenterol. 2015;49(5):438-447.
Winkler E, Schildmann J. Decision making with patients with advanced cancer. A contribution from clinical ethics. Onkologe. 2015;21(7):630-636.
Wiskemann J, Friedmann-Bette B. Potenzial körperlicher Aktivität in Prävention und Therapie chronisscher Erkrankungen. Aktuel Ernahrungsmed. 2015;40(389-408):20.
Wiskemann J, Kleindienst N, Kuehl R, Dreger P, Schwerdtfeger R, Bohus M. Effects of physical exercise on survival after allogeneic stem cell transplantation. Int J Cancer. 2015;137(11):2749-2756.
Wiskemann J, Kuehl R, Dreger P, Huber G, Kleindienst N, Ulrich CM, Bohus M. Physical Exercise Training versus Relaxation in Allogeneic stem cell transplantation (PETRA Study) - Rationale and design of a randomized trial to evaluate a yearlong exercise intervention on overall survival and side-effects after allogeneic stem cell transplantation. Bmc Cancer. 2015;15:619.
Zhou XG, Li JL, Marx C, Tolstov Y, Rauch G, Herpel E, Macher-Goeppinger S, Roth W, Grullich C, Pahernik S, Hohenfellner M, Duensing S. Uncoupling of PUMA Expression and Apoptosis Contributes to Functional Heterogeneity in Renal Cell Carcinoma Prognostic and Translational Implications. Transl Oncol. 2015;8(6):480-486.
Zörnig I, Halama N, Bermejo JL, Ziegelmeier C, Dickes E, Migdoll A, Kaiser I, Waterboer T, Pawlita M, Grabe N, Ugurel S, Schadendorf D, Falk C, Eichmüller SB, Jäger D. Prognostic significance of spontaneous antibody responses against tumor-associated antigens in malignant melanoma patients. Int J Cancer. 2015;136(1):138-151.
Brücken bauen. Das Marsilius-Kolleg und seine fellows 2008-2014. Hrsg.: Just T, Rausch T, Schneidmueller B. Medizinethik als Grenzgang. Winkler EC. ISBN 978-3-8253-6368-0; 2014, S.248-250. Verlag: Universitätsverlag Winter, Heidelberg
Computational biophysics of the skin. Hrsg.: Querleux B. Graphical multi-scale modeling of epidermal homeostasis with EPISIM. Suetterlin T, Grabe N. ISBN 978-981-4463-84-3; 2014, S. 421-460. Verlag: Pan Stanford Publishing, Singapore
Fatigue bei Krebserkrankungen. Hrsg.: Heim R, Weis J. Sport- und Bewegungstherapie. Baumann FT, Wiskemann J. ISBN 978-3-7945-2946-9; 2014, S.154-165. Verlag: Schattauer Verlag, Stuttgart
Therapeutic Antibodies, 2nd Edition. Hrsg.: Duebel S, Reichert JM. Antibody targeted drugs: from chemical immunoconjugates to recombinant fusion proteins. Krauss J, Mavratzas A, Arndt MAE, Kiesgen S. ISBN 978-3-527-32937-3; 2014 Sept. Verlag: Wiley VCH
Zeitschriften
Efficacy of subcutaneous Bortezomib in the management of patients with multiple myeloma or relapsed mantle cell lymphoma Podar K. Clinical Medicine Insights: Therapeutics. 2014:6; 15-23. doi: 10.4137/CMT.S9308.
Targeting Mcl-1 for multiple myeloma (MM) therapy: drug-induced generation of Mcl-1 fragment Mcl-1(128-350) triggers MM cell death via c-Jun upregulation. Fan F, Tonon G, Bashari MH, Vallet S, Antonini E, Goldschmidt H, Schulze-Bergkamen H, Opfermann JT, Sattler M, Anderson KC, Jaeger D, Podar K. Cancer Lett. 2014 Feb 28;343(2):286-94. doi: 10.1016/j.canlet.2013.09.042. Epub 2013 Oct 8.
Generation of "LYmph Node Derived Antibody Libraries" (LYNDAL) for selecting fully human antiviral antibody fragments with therapeutic potential. Diebolder P, Keller A, Haase S, Schlegelmilch A, Kiefer JD, Karimi T, Weber T, Moldenhauer G, Kehm R, Eis-Hübinger AM, Jaeger D, Federspil PA, Herold-Mende C, Dyckhoff G, Kontermann RE, Arndt MA, Krauss J. MAbs. 2014 Jan-Feb;6(1):130-42.
Targeting cell death signaling in colorectal cancer: current strategies and future perspectives. Koehler BC, Jaeger D, Schulze-Bergkamen H. World J Gastroenterol. 2014 Feb 28;20(8):1923-34. doi: 10.3748/wjg.v20.i8.1923.
Pan-Bcl-2 inhibitor Obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells. Koehler BC, Scherr AL, Lorenz S, Elssner C, Kautz N, Welte S, Jaeger D, Urbanik T, Schulze-Bergkamen H. PLOS ONE 2014. (in press)
Chemotherapy for advanced pancreatic adenocarcinoma in elderly patients (≥70 years of age): a retrospective cohort study at the National Center for Tumor Diseases Heidelberg Berger AK, Abel U, Komander C, Harig S, Jaeger D, Springfeld C. Pancreatology. 2014 May-Jun;14(3):211-5. doi: 10.1016/j.pan.2014.03.004. Epub 2014 Mar 18.
Ethische Herausforderungen der Genomsequenzierung in der translationalen Forschung und Antworten aus dem EURAT-Projekt. Winkler EC, Schickhardt C. J Lab Med. 2014;38(4):211-220. doi: 10.1515/labmed-2014-0027, August 2014.
Advance care planning in oncology – ethical and medical competences are needed. Schildmann J, Winkler EC. Oncol Res Treat. 2014;37(1-2). doi: 10.1159/000358160. 2014 Jan 24.
Efficacy of exercise training in SCT patients-who benefits most? Wiskemann J, Kuehl R, Dreger P, Schwerdtfeger R, Huber G, Ulrich CM, Jaeger D, Bohus, M. Bone Marrow Transplant. 2014 Mar;49(3):443-8. doi: 10.1038/bmt.2013.194. Epub 2013 Dec 9.
Multidisciplinary health care needs of psychologically distressed cancer patients in a Comprehensive Cancer Center. Schiel RO, Brechtel A, Hartmann M, Taubert A, Walther J, Wiskemann J, Roetzer I, Becker N, Jaeger D, Herzog W, Friederich HC. Dtsch Med Wochenschr. 2014 Mar;139(12):587-91. doi: 10.1055/s-0034-1369856. Epub 2014 Mar 11.
The big mystery. Delorme S, Jaeger D. Radiologe. 2014 Feb;54(2):106. doi: 10.1007/s00117-013-2543-0.
Efficacy and safety of trastuzumab-based therapy in combination with different chemotherapeutic regimens in advanced esophagogastric cancer - a single cancer-center experience. Haag GM, Apostolidis L, Jaeger D. Tumori. 2014 May-Jun;100(3):237-42. doi: 10.1700/1578.17188.
Survival of patients with initially unresectable colorectal liver metastases treated with FOLFOX/cetuximab or FOLFIRI/cetuximab in a multidisciplinary concept (CELIM study). Folprecht G1, Gruenberger T, Bechstein W, Raab HR, Weitz J, Lordick F, Hartmann JT, Stoehlmacher-Williams J, Lang H, Trarbach T, Liersch T, Ockert D, Jaeger D, Steger U, Suedhoff T, Rentsch A, Köhne CH. Ann Oncol. 2014 May;25(5):1018-25. doi: 10.1093/annonc/mdu088. Epub 2014 Feb 27.
Assessing patient-caregiver communication in cancer-a psychometric validation of the Cancer Communication Assessment Tool (CCAT-PF) in a German sample. Haun MW, Sklenarova H, Winkler EC, Huber J, Thomas M, Siminoff LA, Woll M, Brechtel A, Herzog W, Hartmann M. Support Care Cancer. 2014 Sep;22(9):2473-8. doi: 10.1007/s00520-014-2241-0. Epub 2014 Apr 11.
Antiproliferative efficacies but minor drug transporter inducing effects of paclitaxel, cisplatin, or 5-fluorouracil in a murine xenograft model for head and neck squamous cell carcinoma. Theile D, Gal Z, Warta R, Rigalli J, Lahrmann B, Grabe N, Herold-Mende C, Dyckhoff G, Weiss J Cancer Biol Ther. 2014 April; 15:4, 436-442. doi: 10.4161/cbt.27632. Epub 2014 Jan 21.
Prognostic significance of spontaneous antibody responses against tumor-associated antigens in malignant melanoma patients. Zoernig I, Halama N, Lorenzo Bermejo J, Ziegelmeier C, Dickes E, Migdoll A, Kaiser I, Waterboer T, Pawlita M, Grabe N, Ugurel S, Schadendorf D, Falk C, Eichmueller SB, Jaeger D. Int J Cancer. 2014 May 17. doi: 10.1002/ijc.28980. [Epub ahead of print].
Pathogenic role of the eight probably/possibly carcinogenic HPV types 26, 53, 66, 67, 68, 70, 73 and 82 in cervical cancer. Halec G, Alemany L, Lloveras B, Schmitt M, Alejo M, Bosch FX, Tous S, Klaustermeier JE, Guimerà N, Grabe N, Lahrmann B, Gissmann L, Quint W, Bosch FX, de Sanjose S, Pawlita M. J Pathol. 2014 Jul 16. doi: 10.1002/path.4405. [Epub ahead of print]
Aberrant self-renewal and quiescence contribute to the aggressiveness of glioblastoma. Campos B, Gal Z, Baader A, Schneider T, Sliwinski C, Gassel K, Bageritz J, Grabe N, von Deimling A, Beckhove P, Mogler C, Goidts V, Unterberg A, Eckstein V, Herold-Mende C. J Pathol. 2014 Sep;234(1):23-33. doi: 10.1002/path.4366.
Stem cell Transplantation for Eradication of Minimal Pancreatic Cancer persisting after surgical Excision (STEMPACE Trial, ISRCTN47877138): study protocol for a phase II study. Schmitz-Winnethal FH, Schmidt T, Lehmann M, Beckhove P, Kieser M, Ho AD, Dreger, Buechler MW. BMC Cancer. 2014 Mar 10;14:168. doi: 10.1186/1471-2407-14-168.
A vaccine targeting mutant IDH1 induces antitumour immunity. Schumacher T, Bunse L, Pusch S, Sahm F, Wiestler B, Quandt J, Menn O, Osswald M, Oezen I, Ott M, Keil M, Balß J, Rauschenbach K, Grabowska AK, Vogler I, Diekmann J, Trautwein N, Eichmueller SB, Okun J, Stevanović S, Riemer AB, Sahin U, Friese MA, Beckhove P, von Deimling A, Wick W, Platten M. Nature. 2014 Aug 21;512(7514):327-327. doi: 10.1038/nature13387.
Randomized controlled trial of resistance training in breast cancer patients receiving adjuvant radiotherapy: results on cancer-related fatigue and quality of life. Steindorf K, Schmidt ME, Klassen O, Ulrich C, Oelmann J, Habermann N, Beckhove P, Owen R, Debus J, Wiskemann J, Potthoff K. Ann Oncol. 2014 Aug 5; pii:mdu374.
Plerixafor is effective given either preemptively or as a rescue strategy in poor stem cell mobilizing patients with multiple myeloma. Cheng J, Schmitt M, Wuchter P, Buss EC, Witzens-Harig M, Neben K, Hundemer M, Hillengass J, Alexi R, Goldschmidt H, Chen BA, Ho AD, Schmitt A. Transfusion. 2014 Aug 13. doi: 10.1111/trf.12813.
Bortezomib improves outcome after SCT in multiple myeloma patients with end-stage renal failure. Breitkreutz I, Heiss C, Perne A, Beimler J, Jaeger D, Egerer G, Ho AD, Neben K, Zeier M, Goldschmidt H, Raab MS. Bone Marrow Transpl. 2014 Aug 4. doi: 10.1038/bmt.2014.165.
Risk of multiple myeloma is associated with polymorphisms within telomerase genes and telomere length. Campa D, Martino A, Varkonyi J, Lesueur F, Jamroziak K, Landi S, Jurczyszyn A, Marques H, Andersen V, Jurado M, Brenner H, Petrini M, Vogel U, García-Sanz R, Buda G, Gemignani F, Ríos R, Vangsted AJ, Dumontet C, Martínez-López J, Moreno MJ, Stępień A, Wątek M, Moreno V, Dieffenbach AK, Rossi AM, Butterbach K, Jacobsen SE, Goldschmidt H, Sainz J, Hillengass J, Orciuolo E, Dudziński M, Weinhold N, Reis RM, Canzian F. Int J Cancer. 2014 Jul 28. doi: 10.1002/ijc.29101.
European Perspective on Multiple Myeloma Treatment Strategies in 2014. Ludwig H, Sonneveld P, Davies F, Bladé J, Boccadoro M, Cavo M, Morgan G, de la Rubia J, Delforge M, Dimopoulos M, Einsele H, Facon T, Goldschmidt H, Moreau P, Nahi H, Plesner T, San-Miguel J, Hajek R, Sondergeld P, Palumbo A. Oncologist. 2014 Aug;19(8):829-844.
Immunoglobulin light-chain amyloidosis shares genetic susceptibility with multiple myeloma. Weinhold N, Foersti A, da Silva Filho MI, Nickel J, Campo C, Hoffmann P, Noethen MM, Hose D, Goldschmidt H, Jauch A, Langer C, Hegenbart U, Schoenland SO, Hemminki K. Leukemia. 2014 Jul 3. doi: 10.1038/leu.2014.208.
Extramedullary relapse after accidental head injury in a patient with multiple myeloma. Merz M, Schweizer L, Kentar M, Schneider T, Goldschmidt H, Hillengass J. Ann Hematol. 2014 Jun 29. [Epub ahead of print]
Combination of international scoring system 3, high lactate dehydrogenase, and t(4;14) and/or del(17p) identifies patients with multiple myeloma (MM) treated with front-line autologous stem-cell transplantation at high risk of early MM progression-related death. Moreau P, Cavo M, Sonneveld P, Rosinol L, Attal M, Pezzi A, Goldschmidt H, Lahuerta JJ, Marit G, Palumbo A, van der Holt B, Bladé J, Petrucci MT, Neben K, san Miguel J, Patriarca F, Lokhorst H, Zamagni E, Hulin C, Gutierrez N, Facon T, Caillot D, Benboubker L, Harousseau JL, Leleu X, Avet-Loiseau H, Mary JY. J Clin Oncol. 2014 Jul 10;32(20):2173-80. doi: 10.1200/JCO.2013.53.0329.
A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy. Kassambara A, Gourzones-Dmitriev C, Sahota S, Rème T, Moreaux J, Goldschmidt H, Constantinou A, Pasero P, Hose D, Klein B. Oncotarget. 2014 May 15;5(9):2487-98.
Sensitivity of whole-body CT and MRI versus projection radiography in the detection of osteolyses in patients with monoclonal plasma cell disease. Wolf MB, Murray F, Kilk K, Hillengass J, Delorme S, Heiss C, Neben K, Goldschmidt H, Kauczor HU, Weber MA. Eur J Radiol. 2014 Jul;83(7):1222-30. doi: 10.1016/j.ejrad.2014.02.008.
Rescue stem cell mobilization with plerixafor economizes leukapheresis in patients with multiple myeloma. Hundemer M, Engelhardt M, Bruckner T, Kraeker S, Schmitt A, Sauer S, Neben K, Witzens-Harig M, Goldschmidt H, Ho AD, Wuchter P. J Clin Apheresis. 2014 Apr 26. doi: 10.1002/jca.21323.
Infiltration patterns in monoclonal plasma cell disorders: correlation of magnetic resonance imaging with matched bone marrow histology. Andrulis M, Baeuerle T, Goldschmidt H, Delorme S, Landgren O, Schirmacher P, Hillengass J. Eur J Radiol. 2014 Jun;83(6):970-4. doi: 10.1016/j.ejrad.2014.03.005.
Visceral leishmaniasis in a patient with relapsed multiple myeloma receiving high-dose melphalan and autologous stem cell transplant. Radujkovic A, Hundemer M, Eisenbach C, Luft T, Penzel R, Goldschmidt H, Ho AD, Bellos F. Leuk Lymphoma. 2014 Jun 16:1-3. [Epub ahead of print] No abstract available.
Appearance of monoclonal plasma cell diseases in whole-body magnetic resonance imaging and correlation with parameters of disease activity. Kloth JK, Hillengass J, Listl K, Kilk K, Hielscher T, Landgren O, Delorme S, Goldschmidt H, Kauczor HU, Weber MA. Int J Cancer. 2014 Apr 7. doi: 10.1002/ijc.28877.
PET/CT studies of multiple myeloma using (18) F-FDG and (18) F-NaF: comparison of distribution patterns and tracers' pharmacokinetics. Sachpekidis C, Goldschmidt H, Hose D, Pan L, Cheng C, Kopka K, Haberkorn U, Dimitrakopoulou-Strauss A. Eur J Nucl Med Mol I. 2014 Jul;41(7):1343-53. doi: 10.1007/s00259-014-2721-y.
Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma. Merz M, Hielscher T, Wagner B, Sauer S, Shah S, Raab MS, Jauch A, Neben K, Hose D, Egerer G, Weber MA, Delorme S, Goldschmidt H, Hillengass J. Leukemia. 2014 Sep;28(9):1902-8. doi: 10.1038/leu.2014.75.
Gain of chromosome 1q21 is an independent adverse prognostic factor in light chain amyloidosis patients treated with melphalan/dexamethasone. Bochtler T, Hegenbart U, Kunz C, Benner A, Seckinger A, Dietrich S, Granzow M, Neben K, Goldschmidt H, Ho AD, Hose D, Jauch A, Schoenland SO. Amyloid. 2014 Mar;21(1):9-17. doi: 10.3109/13506129.2013.854766.
Inherited genetic susceptibility to monoclonal gammopathy of unknown significance. Weinhold N, Johnson DC, Rawstron AC, Försti A, Doughty C, Vijayakrishnan J, Broderick P, Dahir NB, Begum DB, Hosking FJ, Yong K, Walker BA, Hoffmann P, Muehleisen TW, Langer C, Doerner E, Joeckel KH, Eisele L, Noethen MM, Hose D, Davies FE, Goldschmidt H, Morgan GJ, Hemminki K, Houlston RS. Blood. 2014 Apr 17;123(16):2513-7; quiz 2593. doi: 10.1182/blood-2013-10-532283.
Autologous stem cell transplantation for elderly patients with newly diagnosed multiple myeloma in the era of novel agents. Merz M, Neben K, Raab MS, Sauer S, Egerer G, Hundemer M, Hose D, Kunz C, Heiß C, Ho AD, Goldschmidt H, Hillengass J. Ann Oncol. 2014 Jan;25(1):189-95. doi: 10.1093/annonc/mdt509.
Expression of Mucin-1 in multiple myeloma and its precursors: correlation with glycosylation and subcellular localization. Andrulis M, Ellert E, Mandel U, Clausen H, Lehners N, Raab MS, Goldschmidt H, Schwartz-Albiez R. Histopathology. 2014 May;64(6):799-806. doi: 10.1111/his.12330.
Inherited genetic susceptibility to multiple myeloma. Morgan GJ, Johnson DC, Weinhold N, Goldschmidt H, Landgren O, Lynch HT, Hemminki K, Houlston RS. Leukemia. 2014 Mar;28(3):518-24. doi: 10.1038/leu.2013.344.
DNA methylation score is predictive of myeloma cell sensitivity to 5-azacitidine. Moreaux J, Bruyer A, Veyrune JL, Goldschmidt H, Hose D, Klein B. Brit J Haematol. 2014 Feb;164(4):613-6. doi: 10.1111/bjh.12660.
Classical hodgkin lymphoma as de novo B-cell malignancy after treatment of multiple myeloma in the pre-lenalidomide era. Zago M, Adam P, Goldschmidt H, Fend F, Kanz L, Weisel K. Cl Lymph Myelom Leuk. 2014 Feb;14(1):e7-e11. doi: 10.1016/j.clml.2013.07.101.
Bortezomib before and after autologous stem cell transplantation overcomes the negative prognostic impact of renal impairment in newly diagnosed multiple myeloma: a subgroup analysis from the HOVON-65/GMMG-HD4 trial. Scheid C, Sonneveld P, Schmidt-Wolf IG, van der Holt B, el Jarari L, Bertsch U, Salwender H, Zweegman S, Blau IW, Vellenga E, Weisel K, Pfreundschuh M, Jie KS, Neben K, van de Velde H, Duehrsen U, Schaafsma MR, Lindemann W, Kersten MJ, Peter N, Haenel M, Croockewit S, Martin H, Wittebol S, Bos GM, van Marwijk-Kooy M, Wijermans P, Goldschmidt H, Lokhorst HM. Haematologica. 2014 Jan;99(1):148-54. doi: 10.3324/haematol.2013.087585.
IMWG consensus on risk stratification in multiple myeloma. Chng WJ, Dispenzieri A, Chim CS, Fonseca R, Goldschmidt H, Lentzsch S, Munshi N, Palumbo A, Miguel JS, Sonneveld P, Cavo M, Usmani S, Durie BG, Avet-Loiseau H; International Myeloma Working Group. Leukemia. 2014 Feb;28(2):269-77. doi: 10.1038/leu.2013.247.
Prognostic significance of whole-body MRI in patients with monoclonal gammopathy of undetermined significance. Hillengass J, Weber MA, Kilk K, Listl K, Wagner-Gund B, Hillengass M, Hielscher T, Farid A, Neben K, Delorme S, Landgren O, Goldschmidt H. Leukemia. 2014 Jan;28(1):174-8. doi: 10.1038/leu.2013.244.
Tumour-site-dependent expression profile of angiogenic factors in tumour-associated stroma of primary colorectal cancer and metastases. Kahlert C, Pecqueux M, Halama N, Dienemann H, Muley T, Pfannschmidt J, Lasitschka F, Klupp F, Schmidt T, Rahbari N, Reissfelder C, Kunz C, Benner A, Falk C, Weitz J, Koch M. Brit J Cancer. 2014 Jan 21;110(2):441-9. doi: 10.1038/bjc.2013.745.
Blood autoantibodies against tumor-associated antigens as biomarkers in early detection of colorectal cancer. Chen H, Werner S, Tao S, Zoernig I, Brenner H. Cancer Lett. 2014 May 1;346(2):178-87. doi: 10.1016/j.canlet.2014.01.007.
CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy. Engeland CE, Grossardt C, Veinalde R, Bossow S, Lutz D, Kaufmann JK, Shevchenko I, Umanksy V, Nettelbeck DM, Weichert W, Jaeger D, von Kalle C, Ungerechts G. Mol Ther. 2014 Aug 26. doi: 10.1038/mt.2014.160.
MicroRNA-mediated multi-tissue detargeting of oncolytic measles virus. Baertsch MA, Leber MF, Bossow S, Singh M, Engeland CE, Albert J, Grossardt C, Jaeger D, von Kalle C, Ungerechts G. Cancer Gene Ther. 2014 Aug 22. doi: 10.1038/cgt.2014.40.
Primary transcriptome map of the hyperthermophilic archaeon Thermococcus kodakarensis. Jaeger D, Foerstner KU, Sharma CM, Santangelo TJ, Reeve JN. BMC Genomics. 2014 Aug 16;15(1):684.
Docetaxel followed by abiraterone in metastatic castration-resistant prostate cancer: efficacy and predictive parameters in a large single center cohort. Hoefner T, Vallet S, Hadaschik BA, Pahernik S, Duensing S, Hohenfellner M, Jaeger D, Gruellich C. World J Urol. 2014 Aug 12. doi: 10.1007/s00345-014-1375-5
Prognostic significance of spontaneous antibody responses against tumor-associated antigens in malignant melanoma patients. Zoernig I, Halama N, Lorenzo Bermejo J, Ziegelmeier C, Dickes E, Migdoll A, Kaiser I, Waterboer T, Pawlita M, Grabe N, Ugurel S, Schadendorf D, Falk C, Eichmüller SB, Jaeger D. Int J Cancer. 2014 May 17. doi: 10.1002/ijc.28980.
Randomized controlled trial to evaluate the effects of ethyl-2-cyanoacrylate on pain intensity and quality of life in head and neck cancer patients suffering from cetuximab-induced rhagades during radioimmunotherapy: the support trial. Potthoff K, Habl G, Bruckner T, Suppan C, Hassel J, Jaeger D, Indorf M, Debus J. BMC Cancer. 2014 Apr 17;14:270. doi: 10.1186/1471-2407-14-270.
Post-therapeutic response evaluation by a combination of endoscopy and CT scan in esophagogastric adenocarcinoma after chemotherapy: better than its reputation. Blank S, Lordick F, Bader F, Burian M, Dobritz M, Grenacher L, Becker K, Weichert W, Langer R, Sisic L, Stange A, Jaeger D, Buechler M, Bruckner T, Siewert J, Ott K. Gastric Cancer. 2014 Apr 11. doi: 10.1007/s10120-014-0367-x
Adjuvant therapy after resection of colorectal liver metastases: the predictive value of the MSKCC clinical risk score in the era of modern chemotherapy. Rahbari NN, Reissfelder C, Schulze-Bergkamen H, Jaeger D, Buechler MW, Weitz J, Koch M. BMC Cancer. 2014 Mar 11;14:174. doi: 10.1186/1471-2407-14-174.
Influence of interferon-alpha combined with chemo (radio) therapy on immunological parameters in pancreatic adenocarcinoma. Karakhanova S, Mosl B, Harig S, von Ahn K, Fritz J, Schmidt J, Jaeger D, Werner J, Bazhin AV. Int J Mol Sci. 2014 Mar 7;15(3):4104-25. doi: 10.3390/ijms15034104.
Trends in epidemiology, treatment, and survival of hepatocellular carcinoma patients between 1998 and 2009: an analysis of 1066 cases of a German HCC Registry. Weinmann A, Koch S, Niederle IM, Schulze-Bergkamen H, Koenig J, Hoppe-Lotichius M, Hansen T, Pitton MB, Dueber C, Otto G, Schuchmann M, Galle PR, Woerns MA. J Clin Gastroenterol. 2014 Mar;48(3):279-89. doi: 10.1097/MCG.0b013e3182a8a793.
Predictive Scores in Primary Biliary Cirrhosis: A Retrospective Single Center Analysis of 204 Patients. Weinmann A, Sattler T, Unold HP, Grambihler A, Teufel A, Koch S, Schuchmann M, Biesterfeld S, Woerns MA, Galle PR, Schulze-Bergkamen H. J Clin Gastroenterol. 2014 Jul 10. doi: 10.1097/MCG.0000000000000176
Phenotyping of peripheral blood mononuclear cells of patients with advanced heavily pre-treated adenocarcinoma of the stomach and gastro-esophageal junction. Kuehnle MC, Attig S, Britten CM, Schulze-Bergkamen H, Lordick F, von Wichert G, Thuss-Patience P, Stein A, Schuler M, Bassermann F, Sahin U, Tuereci O. Cancer Immunol Immun. 2014 Aug 28. doi: 10.1007/s00262-014-1596-x
Classification of exercise intensities in hematological cancer patients during and after allo-HSCT. Kuehl R, Scharhag-Rosenberger F, Schommer K, Schmidt ME, Dreger P, Huber G, Bohus M, Ulrich CM, Wiskemann J. Med Sci Sport Exer. 2014 Sep 8. [Epub ahead of print]
Cardiorespiratory fitness in breast cancer patients undergoing adjuvant therapy. Klassen O, Schmidt ME, Scharhag-Rosenberger F, Sorkin M, Ulrich CM, Schneeweiss A, Potthoff K, Steindorf K, Wiskemann J. Acta Oncol. 2014 May 16:1-10.
Irisin does not mediate resistance training-induced alterations in resting metabolic rate. Scharhag-Rosenberger F, Meyer T, Wegmann M, Ruppenthal S, Kaestner L, Morsch A, Hecksteden A. Med Sci Sports Exer. 2014 Sep;46(9):1736-43. doi: 10.1249/MSS.0000000000000286.
Blood lactate concentrations are mildly affected by mobile gas exchange measurements. Scharhag-Rosenberger F, Wochatz M, Otto C, Cassel M, Mayer F, Scharhag J. Int J Sports Med. 2014 Jun;35(7):590-4. doi: 10.1055/s-0033-1354386.
Can more than one incremental cycling test be performed within one day? Scharhag-Rosenberger F, Carlsohn A, Lundby C, Schueler S, Mayer F, Scharhag J. Eur J Sport Sci. 2014;14(5):459-67. doi: 10.1080/17461391.2013.853208.
Limited benefit of Fatmax-test to derive training prescriptions. Schwindling S, Scharhag-Rosenberger F, Kindermann W, Meyer T. Int J Sports Med. 2014 Apr;35(4):280-5. doi: 10.1055/s-0033-1349106.
Wissenschaftliche Studien zu körperlichem Training bei onkologischen Patienten: Empfehlungen zu den Erhebungsmethoden. Scharhag-Rosenberger F, Becker T, Streckmann F, Schmidt K, Berling A, Bernardi A, Engeroff T, Exner AK, Gutekunst K, Hofmeister D, Jensen W, Kaehnert H, Kneis S, Limbach M, Mau-Moelle A, Roecker K, Schmidt M, Schmidt T, Stoeckel T, Wehrle A, Wisemann J, Zimmer P, Zopf E, Steindorf K. Deutsche Zeitschrift für Sportmedizin. 2014 – in print.
Nebenwirkungsorientierte Behandlungspfade für die bewegungstherapeutische Betreuung von onkologischen Patienten. Wiskemann J, Scharhag-Rosenberger F. B & G. 2014 30(4):146-150. doi: 10.1055/s-0034-1384418
Physical performance and psychosocial status in lung cancer patients: results from a pilot study. Hummler S, Thomas M, Hoffmann B, Gaertner P, Zoz M, Huber G, Ulrich CM, Wiskemann J. Oncol Res Treat. 2014;37(1-2):36-41. doi: 10.1159/000358157.
Exercise in patients with non-small cell lung cancer. Kuehr L, Wiskemann J, Abel U, Ulrich CM, Hummler S, Thomas M. Med Sci Sports Exer. 2014 Apr;46(4):656-63. doi: 10.1249/MSS.0000000000000158.
Impact of resistance training in cancer survivors: a meta-analysis. Strasser B, Steindorf K, Wiskemann J, Ulrich N. Med Sci Sports Exer. 2013 Nov;45(11):2080-90. doi: 10.1249/MSS.0b013e31829a3b63.
Exercise in breast cancer patients: impact on health. Schmidt M, Wiskemann J. Steindorf K. Breast Cancer Management. 2014 Vol. 3, No. 3, Pages 241-250 , doi: 10.2217/bmt.14.12
What explains the intention to be physically active in cancer patients? – Different determinants for active and insufficiently active patients. Ungar N, Sieverding M, Ulrich CM, Wiskemann J. Psychosocial Oncology. 2014 (accepted)
Factors influencing willingness for participation in an exercise intervention study in breast cancer patients during radiotherapy. Gollhofer SM, Wiskemann J, Schmidt M, Klassen O, Ulrich CM, Oelmann J, Hof H, Pottkopff K, Steindorf K. BMC Cancer. 2014 (submitted and under review)
Standards der Sportmedizin: Krafttraining als Supportivtherapie bei onkologischen Patienten. Wiskemann J, Steindorf K. Deutsche Zeitschrift für Sportmedizin. 2014 65(1):22-24.
Potential physiologic and molecular mechanisms linking endurance and resistance training with beneficial effects for cancer patients. Steindorf K, Schmidt ME, Wiskemann J, Ulrich CM. Deutsche Zeitschrift für Sportmedizin. 2014 (accepted)
Cabozantinib: A MET, RET, and VEGFR2 Tyrosine Kinase Inhibitor Small Molecules in Oncology. Gruellich C. Cancer Res. 2014;201:207-14. doi: 10.1007/978-3-642-54490-3_12.
Evolving therapeutic concepts in prostate cancer based on genome-wide analyses (Review). Georgi B, Korzeniewski N, Hadaschik B, Gruellich C, Roth W, Sültmann H, Pahernik S, Hohenfellner M, Duensing S. Int J Oncol. 2014 Oct;45(4):1337-44. doi: 10.3892/ijo.2014.2567.
Rabbit anti-T-lymphocyte globulin (ATG) persists with differential reactive in patients’ sera after full hematopoitic regeneration from allogeneic stem cell transplantation. Ziegler C, Finke J, Gruellich C. Transp Immunol. 2014 May;30(4):136-9. doi: 10.1016/j.trim.2014.03.005.
Excellent local control with IOERT and postoperative EBRT in high grade extremity sarcoma: results from a subgroup analysis of a prospective trial. Roeder F, Lehner B, Schmitt T, Kasper B, Egerer G, Sedlaczek O, Gruellich C, Mechtersheimer G, Wuchter P, Hensley FW, Huber PE, Debus J, Bischof M. BMC Cancer. 2014 May 20;14:350. doi: 10.1186/1471-2407-14-350.
Phenotypic drug screening and target validation for improved personalized therapy reveal the complexity of phenotype-genotype correlations in clear cell renal cell carcinoma. Schneider M, Schueler J, Hoefflin R, Korzeniewski N, Gruellich C, Roth W, Teber D, Hadaschik B, Pahernik S, Hohenfellner M, Duensing S. Urol Oncol. 2014 Aug;32(6):877-84. doi: 10.1016/j.urolonc.2014.03.011.
The tyrosine kinase inhibitor nilotinib has antineoplastic activity in prostate cancer cells but up-regulates the ERK survival signal—Implications for targeted therapies. Schneider M, Korzeniewski N, Merkle K, Schueler J, Gruellich C, Hadaschik B, Hohenfellner M, Duensing S. Urol Oncol. 2014 Jul 1. pii: S1078-1439(14)00206-3. doi: 10.1016/j.urolonc.2014.06.001.
A retrospective comparative exploratory study on two methylentetrahydrofolate reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients. Blank S, Rachakonda S, Keller G, Weichert W, Lordick F, Langer R, Springfeld C, Bruckner T, Becker K, Kumar R, Ott K. BMC Cancer. 2014 Feb 3;14:58. doi: 10.1186/1471-2407-14-58.
Is preoperative chemotherapy followed by surgery the appropriate treatmet for signet ring cell containing adenocarcinomas of the esophagogastric junction and stomach? Heger U, Blank S, Wiecha C, Langer R, Weichert W, Lordick F, Bruchner T, Dobritz M, Burian M, Springfeld C, Grenacher L, Siewert JR, Bueckler M, Ott K. Ann Surg Oncol. 2014 May;21(5):1739-48. doi: 10.1245/s10434-013-3462-z.
Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1. Wagner V, Hose D, Seckinger A, Weiz L, Meißner T, Rème T, Breitkreutz I, Podar K, Ho AD, Goldschmidt H, Kraemer A, Klein B, Raab MS. Oncotarget. 2014 Sep 26. [Epub ahead of print]
A gene expression signature for high-risk multiple myeloma. Kuiper R, Broyl A, de Knegt Y, van Vliet MH, van Beers EH, van der Holt B, el Jarari L, Mulligan G, Gregory W, Morgan G, Goldschmidt H, Lokhorst HM, van Duin M, Sonneveld P. Leukemia. 2012 Nov;26(11):2406-13. doi: 10.1038/leu.2012.127. Epub 2012 May 8. Erratum in: Leukemia. 2014 May;28(5):1178-80.
T cell-based targeted immunotherapies for patients with multiple myeloma. Wang L, Jin N, Schmitt A, Greiner J, Malcherek G, Hundemer M, Mani J, Hose D, Raab MS, Ho AD, Chen BA, Goldschmidt H, Schmitt M. Int J Cancer. 2014 Sep 6. doi: 10.1002/ijc.29190.
Aprepitant, Granisetron and Dexamethasone for prevention of chemotherapy-induced nausea and vomiting after high-dose Melphalan in autologous transplantation for multiple myeloma: results of a randomized, placebo-controlled phase III trial. Schmitt T, Goldschmidt H, Neben K, Freiberger A, Huesing J, Gronkowski M, Thalheimer M, Pelzl LH, Mikus G, Burhenne J, Ho AD, Egerer G. J Clin Oncol. 2014 Oct 20;32(30):3413-20. doi: 10.1200/JCO.2013.55.0095.
State of the art treatment of progressive or refractory multiple myeloma. Schmidt-Wolf IG, Straka C, Scheid C, Einsele H, Goldschmidt H, Engelhardt M. Dtsch Med Wochenschr. 2014 Oct;139(41):2091-5. doi: 10.1055/s-0034-1387268.
Nuclear expression of the deubiquitinase CYLD is associated with improved survival in human hepatocellular carcinoma. Welte S, Urbanik T, Elßner C, Kautz N, Koehler BC, Waldburger N, Bermejo JL, Pinna F, Weiss KH, Schemmer P, Jaeger D, Longerich T, Breuhahn K, Schulze-Bergkamen H. PLoS One. 2014 Oct 16;9(10):e110591. doi: 10.1371/journal.pone.0110591. eCollection 2014.
Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity. Fernández-Ulibarri I, Hammer K, Arndt MA, Kaufmann JK, Dorer D, Engelhardt S, Kontermann RE, Hess J, Allgayer H, Krauss J, Nettelbeck DM. Int J Cancer. 2014 Oct 10. doi: 10.1002/ijc.29258.
Prognostic impact of CA 19-9 on outcome after neoadjuvant chemoradiation in patients with locally advanced pancreatic cancer. Combs SE, Habermehl D, Kessel KA, Bergmann F, Werner J, Naumann P, Jaeger D, Buechler MW, Debus J. Ann Surg Oncol. 2014 Aug;21(8):2801-7. doi: 10.1245/s10434-014-3607-8.
Patentanmeldungen
EP 14 18 399.2 Construct for the delivery of a molecule into the cytoplasm of a cell Erfinder: Kiesgen S, Arndt MA, Krauss J.
Praxisfelder angewandter Ethik: ethische Orientierung in Medizin, Politik, Technik und Wirtschaft. Hrsg.: Steger F, Hillerbrand R. Praktische Urteilskraft und institutionelle Ethik als Voraussetzungen für eine gute Entscheidungspraxis in der Klinik. Winkler EC. ISBN 978-3897857537; 2013, S. 67-80. Verlag: mentis, Münster
Current & emerging therapeutics for multiple myeloma. Hrsg.: Raje N, Jagannath. Future directions. Podar K. e-ISBN: 978-1-78084-228-8; Sep 2013, S. 114-135. doi: 10.2217/ebo.13.249. Verlag: Future Medicine, London
Advances in biology and therapy of multiple myeloma: volume 1: basic science. Hrsg.: Munshi NC, Anderson KC. Targeting multiple myeloma tumor angiogenesis: focus on VEGF. Podar K, Anderson KC. e-ISBN: 978-1-4614-4666-8; 2013, S. 283-299. doi: 10.1007/978-1-4614-4666-8_15. Verlag: Springer Science+Business Media, New York
Psychoonkologie Hrsg.: Dorfmueller M, Dietzfelbinger H. Onkologische Ethik. Winkler EC. ISBN: 978-3-437-31602-9; 2013, 2. Auflage, S. 477-497. doi: -. Verlag: Elsevier Urban und Fischer
Journals
Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6. Witzens-Harig M, Hose D, Juenger S, Pfirschke C, Khandelwal N, Umansky L, Seckinger A, Conrad H, Brackertz B, Rème T, Gueckel B, Meißner T, Hundemer M, Ho AD, Rossi JF, Neben K, Bernhard H, Goldschmidt H, Klein B, Beckhove P. Blood. 2013 May 30;121(22):4493-503. doi: 10.1182/blood-2012-05-429415. Epub 2013 Apr 19.
Die Urologie im Konzept der „Comprehensive Cancer Center“. Hadaschik B, Pahernik S, Gruellich C, Sueltmann H, Jaeger D, von Kalle C, Duensing S, Hohenfellner M. Der Urologe. 2013/9:1283-1289. DOI: 10.1007/s00120-013-3313-3.
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Chubb D, Weinhold N, Broderick P, Chen B, Johnson DC, Foersti A, Vijayakrishnan J, Migliorini G, Dobbins SE, Holroyd A, Hose D, Walker BA, Davies FE, Gregory WA, Jackson GH, Irving JA, Pratt G, Fegan C, Fenton JA, Neben K, Hoffmann P, Noethen MM, Muehleisen TW, Eisele L, Ross FM, Straka C, Einsele H, Langer C, Doerner E, Allan JM, Jauch A, Morgan GJ, Hemminki K, Houlston RS, Goldschmidt H. Nat Genet. 2013 Oct;45(10):1221-5. doi: 10.1038/ng.2733. Epub 2013 Aug 18.
Onkologische Therapien – was sind patientenrelevante Endpunkte? Ehmann M, Haerter M, Rambach R, Winkler E. Onkologie. 2013; 36(suppl 6):5-8. doi: 10.1159/000353716.
Multimodal oncological therapy concepts, chemotherapy and immunosuppressive drugs: effects on surgical morbidity and mortality. Berger AK, Jaeger D. Chirurg. 2013; 84(11) 930-6; doi: 10.1007/s00104-013-2512-1.
Necrolytic migratory erythema in a patient with neuroendocrine carcinoma. Gronau M, Jaeger D, Enk AH, Hassel JC. Internal Med. 2013;52(1):151-2. Epub 2013 Jan 1.
Intensity modulated radiotherapy as neoadjuvant chemoradiation for the treatment of patients with locally advanced pancreatic cancer. Outcome analysis and comparison with a 3D-treated patient cohort. Combs SE, Habermehl D, Kessel K, Bergmann F, Werner J, Brecht I, Schirmacher P, Jaeger D, Buechler MW, Debus J. Strahlenther Onkol. 2013 Sep;189(9):738-44. doi: 10.1007/s00066-013-0391-5. Epub 2013 Jul 31.
Personalisierte Medizin und Informed consent: klinische und ethische Erwaegungen im Rahmen der Entwicklung einer best practice Leitlinie fuer die biobankbasierte Ganzgenomforschung in der Onkologie. Winkler EC, Ose D, Glimm H, Tanner K, von Kalle C. Ethik Med. (2013)25:195-203. doi:10.1007/s00481-013-0273-5.
Stathmin regulates keratinocyte proliferation and migration during cutaneous regeneration. Schmitt S, Safferling K, Westphal K, Hrabowski M, Mueller U, Angel P, Wiechert L, Ehemann V, Mueller B, Holland-Cunz S, Stichel D, Harder N, Rohr K, Germann G, Matthaeus F, Schirmacher P, Grabe N, Breuhahn K. PLoS One. 2013 Sep 16;8(9):e75075. doi: 10.1371/journal.pone.0075075. eCollection 2013.
Antitumor T cells responses in bladder cancer are directed against a limited set of antigens and are modulated by regulatory T cells and routine treatment approaches. Horn T, Grab J, Schusdziarra J, Schmid S, Maurer T, Nawroth R, Wolf P, Pritsch M, Gschwend JE, Kuebler HR, Beckhove P Int J Cancer. 2013 Nov;133(9):2145-56. doi: 10.1002/ijc.28233. Epub 2013 Jul 11.
HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas Kostareli E, Holzinger D, Bogatyrova O, Hielscher T, Wichmann G, Keck M, Lahrmann B, Grabe N, Flechtenmacher C, Schmidt CR, Seiwert T, Dyckhoff G, Dietz A, Hoefler D, Pawlita M, Benner A, Bosch FX, Plinkert P, Plass C, Weichenhan D, Hess J. J Clin Invest. 2013 Jun 3;123(6):2488-501. doi: 10.1172/JCI67010. Epub 2013 May 1.
Postischemic brain infiltration of leukocyte subpopulations differs among murine permanent and transient focal cerebral ischemia models Zhou W, Liesz A, Bauer H, Sommer C, Lahrmann B, Valous N, Grabe N, Veltkamp R. Brain Pathol. 2013 Jan;23(1):34-44. doi: 10.1111/j.1750-3639.2012.00614.x. Epub 2012 Aug 7.
Submaxillary gland androgen-regulated protein 3A expression is an unfavorable risk factor for the survival of oropharyngeal squamous cell carcinoma patients after surgery. Koffler J, Holzinger D, Sanhueza GA, Flechtenmacher C, Zaoui K, Lahrmann B, Grabe N, Plinkert PK, Hess J. Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1493-500. doi: 10.1007/s00405-012-2201-6. Epub 2012 Oct 5.
HLA Class II tetramers reveal tissue-specific regulatory T cells that suppress T-cell responses in breast carcinoma patients. Schmidt HH, Ge Y, Hartmann FJ, Conrad H, Klug F, Nittel S, Bernhard H, Domschke C, Schuetz F, Sohn C, Beckhove P. Oncoimmunology. 2013 Jun 1;2(6):e24962. Epub 2013 May 15.
B cell-regulated immune responses in tumor models and cancer patients. Fremd C, Schuetz F, Sohn C, Beckhove P, Domschke C. Oncoimmunology. 2013 Jul 1;2(7):e25443.
Adoptive immunotherapy of metastatic breast cancer: present and future. Stefanovic S, Schuetz F, Sohn C, Beckhove P, Domschke C. Cancer Metast Rev. 2013 32(1-2):309-320.
Bone marrow microenvironment in cancer patients: immunological aspects and clinical implications. Stefanovic S, Schuetz F, Sohn C, Beckhove P, Domschke C. Cancer Metast Rev. 2013; 32: 163-78.
Long-term survival after adoptive bone marrow T cell therapy of advanced metastasized breast cancer: follow-up analysis of a clinical pilot trial. Domschke C, Ge Y, Bernhardt I, Schott S, Keim S, Juenger S, Bucur M, Mayer L, Blumenstein M, Rom J, Heil J, Sohn C, Schneeweiss A, Beckhove P, Schuetz F. Cancer Immunol Immun. 2013 Jun;62(6):1053-60. doi: 10.1007/s00262-013-1414-x. Epub 2013 Apr 18.
PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer. Khan MW, Keshavarzian A, Gounaris E, Melson JE, Cheon EC, Blatner NR, Chen ZE, Tsai FN, Lee G, Ryu H, Barrett TA, Bentrem DJ, Beckhove P, Khazaie K. Clin Cancer Res. 2013 May 1;19(9):2342-54. doi: 10.1158/1078-0432.CCR-12-2623. Epub 2013 Mar 13.
Randomized controlled trial to evaluate the effects of progressive resistance training compared to progressive muscle relaxation in breast cancer patients undergoing adjuvant radiotherapy: the BEST study. Potthoff K, Schmidt ME, Wiskemann J, Hof H, Klassen O, Habermann N, Beckhove P, Debus J, Ulrich CM, Steindorf K. BMC Cancer. 2013 Mar 28;13:162. doi: 10.1186/1471-2407-13-162.
Effects of cyclophosphamide and IL-2 on regulatory CD4+ T cell frequency and function in melanoma patients vaccinated with HLA-class I peptides: impact on the antigen-specific T cell response. Camisaschi C, Filipazzi P, Tazzari M, Casati C, Beretta V, Pilla L, Patuzzo R, Maurichi A, Cova A, Maio M, Chiarion-Sileni V, Tragni G, Santinami M, Vergani B, Villa A, Berti E, Umansky L, Beckhove P, Umansky V, Parmiani G, Rivoltini L, Castelli C. Cancer Immunol Immun. 2013 May;62(5):897-908. doi: 10.1007/s00262-013-1397-7. Epub 2013 Apr 16.
Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model. Sevko A, Michels T, Vrohlings M, Umansky L, Beckhove P, Kato M, Shurin GV, Shurin MR, Umansky V. J Immunol. 2013 Mar 1;190(5):2464-71. doi: 10.4049/jimmunol.1202781. Epub 2013 Jan 28.
T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer. Bauer K, Nelius N, Reuschenbach M, Koch M, Weitz J, Steinert G, Kopitz J, Beckhove P, Tariverdian M, von Knebel Doeberitz M, Kloor M. Cancer Immunol Immun. 2013 Jan;62(1):27-37. doi: 10.1007/s00262-012-1303-8. Epub 2012 Jun 23.
Phase I study evaluating the treatment of patients with locally advanced pancreatic cancer with carbon ion radiotherapy: the PHOENIX-01 trial. Combs SE, Habermehl D, Kieser M, Dreher C, Werner J, Haselmann R, Jaekel O, Jaeger D, Buechler MW, Debus J. BMC Cancer. 2013 Sep 14;13:419. doi: 10.1186/1471-2407-13-419.
Krüppel-like factor 4 blocks tumor cell proliferation and promotes drug resistance in multiple myeloma. Schoenhals M, Kassambara A, Veyrune JL, Moreaux J, Goldschmidt H, Hose D, Klein B. Haematologica. 2013 Sep;98(9):1442-9. doi: 10.3324/haematol.2012.066944. Epub 2013 Apr 12.
Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project. Avet-Loiseau, H, Durie BG, Cavo M, Attal M, Gutierrez N, Haessler J, Goldschmidt H, Hajek R, Lee JH, Sezer O, Barlogie B, Crowley J, Fonseca R, Testoni N, Ross F, Rajkumar SV, Sonneveld P, Lahuerta J, Moreau P, Morgan G. Leukemia. 2013 Mar;27(3):711-7. doi: 10.1038/leu.2012.282. Epub 2012 Oct 3.
Expression of Mucin-1 in multiple myeloma and its precursors: correlation with glycosylation and subcellular localization. Andrulis M, Ellert E, Mandel U, Clausen H, Lehners N, Raab MS, Goldschmidt H, Schwartz-Albiez R. Histopathology. 2014 May;64(6):799-806. doi: 10.1111/his.12330. Epub 2014 Jan 21.
Targeting the BRAF V600E mutation in multiple myeloma. Andrulis M, Lehners N, Capper D, Penzel R, Heining C, Huellein J, Zenz T, von Deimling A, Schirmacher P, Ho AD, Goldschmidt H, Neben K, Raab MS. Cancer Discov. 2013 Aug;3(8):862-9. doi: 10.1158/2159-8290.CD-13-0014. Epub 2013 Apr 23.
Psychosocial support in patients with multiple myeloma at time of diagnosis: who wants what? Lamers J, Hartmann M, Goldschmidt H, Brechtel A, Hillengass J, Herzog W. Psychooncology. 2013 Apr;22 (10):2313-2320. doi: 10.1002/pon.3284. [Epub ahead of print]
Intravoxel incoherent motion imaging for assessment of bone marrow infiltration of monoclonal plasma cell diseases. Shah R, Stieltjes B, Andrulis M, Pfeiffer R, Sumkauskaite M, Delorme S, Schlemmer HP, Goldschmidt H, Landgren O, Hillengass J. Ann Hematol. 2013 Nov;92(11):1553-7. doi: 10.1007/s00277-013-1786-1. Epub 2013 May 17.
Meeting report in the 4th Heidelberg Myeloma Workshop: current status and developments in diagnosis and therapy of multiple myeloma. Hillengass J, Maximilian M, Goldschmidt H. J Cancer Res Clin. 2013 Nov;139(11):1807-11. doi: 10.1007/s00432-013-1468-3. Epub 2013 Jul 18.
Autologous/reduced-intensity allogeneic stem cell transplantation versus autologous transplantation in multiple myeloma: long-term results of the EBMT-NMAM2000 study Gahrton G, Iacobelli S, Bjoerkstrand B, Hegenbart U, Gruber A, Greinix H, Volin L, Narni F, Carella AM, Beksac M, Bosi A, Milone G, Corradini P, Schoenland S, Friberg K, van Biezen A, Goldschmidt H, de Witte T, Morris C, Niederwieser D, Garderet L, Kroeger N. Blood. 2013 Jun 20;121(25):5055-63. doi: 10.1182/blood-2012-11-469452. Epub 2013 Mar 12.
Wound healing revised: a novel reepithelialization mechanism revealed by in vitro and in silico models. Safferling K, Suetterlin T, Westphal K, Ernst C, Breuhan K, James M, Jaeger D, Halama N, Grabe N. J Cell Biol. 2013 Nov 25;203(4):691-709. doi: 10.1083/jcb.201212020.
Inhibition of DEPDC1A, a bad prognostic marker in multiple myeloma, delays growth and induces mature plasma cell markers in malignant plasma cells. Kassambara A, Schoenhals M, Moreaux J, Veyrune JL, Rème T, Goldschmidt H, Hose D, Klein B. PLoS One. 2013 Apr 30;8(4):e62752. doi: 10.1371/journal.pone.0062752. Print 2013.
Gene expression-based prediction of myeloma cells sensitivity to histone deacetylase inhibitors. Moreaux J, Reme T, Leonard W, Veyrune JL. Requirand G, Goldschmidt H, Hose D, Klein B. Br J Cancer. 2013 Aug 6;109(3):676-85. doi: 10.1038/bjc.2013.392. Epub 2013 Jul 18.
Hepatitis B virus infection is associated with deletion of chronmosome 8p in multiple myeloma. Becker N, Byl A, Friedrich S, Jauch A, Schnitzler P, Egerer G, Ho AD, Goldschmidt H, Neben K Eur J Haematol. 2013 Apr;90(4):279-85. doi: 10.1111/ejh.12018. Epub 2012 Nov 22.
Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trial. Miguel JS, Weisel K, Moreau P, Lacy M, Song K, Delforge M, Karlin L, Goldschmidt H, Banos A, Oriol A, Alegre A, Chen C, Cavo M, Garderet L, Ivanova V, Martinez-Lopez J, Belch A, Palumbo A, Schey S, Sonneveld P, Yu X, Sternas L, Jacques C, Zaki M, Dimopoulos M. Lancet Oncol. 2013 Oct;14(11):1055-66. doi: 10.1016/S1470-2045(13)70380-2. Epub 2013 Sep 3.
Bortezomib-based versus Nonbortezomib-basedinduction treatment before autologous stem-cell transplantation in patients with previously untreated multiple myeloma: a meta-analysis of phase III randomized, controlled trials. Sonneveld P, Goldschmidt H, Rosiñol L, Bladé J, Lahuerta JJ, Cavo M, Tacchetti P, Zamagni E, Attal M, Lokhorst HM, Desai A, Cakana A, Liu K, van de Velde H, Esseltine DL, Moreau P. J Clin Oncol. 2013 Sep 10;31(26):3279-87. doi: 10.1200/JCO.2012.48.4626. Epub 2013 Jul 29.
Vorinostat or placebo in combination with bortezomib in patients with multiple myeloma (VANTAGE 088): a multicentre, randomised, double-blind study. Dimopoulos M, Siegel DS, Lonial S, Qi J, Hajek R, Facon T, Rosinol L, Williams C, Blacklock H, Goldschmidt H, Hungria V, Spencer A, Palumbo A, Graef T, Eid JE, Houp J, Sun L, Vuocolo S, Anderson KC. Lancet Oncol. 2013 Oct;14(11):1129-40. doi: 10.1016/S1470-2045(13)70398-X. Epub 2013 Sep 19.
Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins. Enkirch T, Kneissl S, Hoyler B, Ungerechts G, Stremmel W, Buchholz CJ, Springfel.d C. Gene Ther. 2013 Jan;20(1):16-23. doi: 10.1038/gt.2011.209. Epub 2012 Jan 5.
A reliable risk score for stage IV esophagogasstric cancer. Blank S, Lordick F, Dobritz M, Grenacher L, Burian M, Langer R, Roth W, Schaible A, Becker K, Blaeker H, Sisic L, Stange A, Compani P, Schulze-Bergkamen H, Jaeger D, Buechler M, Siewert JR, Ott K. Eur J Surg Oncol. 2013 Aug;39(8):823-30. doi: 10.1016/j.ejso.2013.00.83505. Epub 2013 Jan 31.
Bisphosphonate treatment and renal function in 201 myeloma patients undergoing stem cell transplantation. Schmitt S, Hielscher T, Baldus C, Neben K, Egerer G, Hillengaß J, Raab M, Hose D, Ho AD, Bergner R, Goldschmidt H, Moehler TM. Int J Hematol. 2013 Jun;97(6):765-72. doi: 10.1007/s12185-013-1320-1. Epub 2013 Apr 25.
Posterior reversible leukoencephalopathy syndrome associated with pazopanib. Foerster R, Welzel T, Debus J, Gruellich C, Jaeger D, Potthoff K. Case Rep Oncol. 2013 Apr 6;6(1):204-8. doi: 10.1159/000350742. Print 2013 Jan.
Nab-Paclitaxel monotherapy as a treatment of patients with metastatic breast cancer in routine clinical practice. Aigner J, Marmé F, Smetanay K, Schuetz F, Jaeger D, Schneeweiss A. Anticancer Res. 2013 Aug;33(8):3407-13.
Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors. Rusakiewicz S, Semeraro M, Sarabi M, Desbois M, Locher C, Mendez R, Vimond N, Concha A, Garrido F, Isambert N, Chaigneau L, Le Brun-Ly V, Dubreuil P, Cremer I, Caignard A, Poirier-Colame V, Chaba K, Flament C, Halama N, Jaeger D, Eggermont A, Bonvalot S, Commo F, Terrier P, Opolon P, Emile JF, Coindre JM, Kroemer G, Chaput N, Le Cesne A, Blay JY, Zitvogel L. Cancer Res. 2013 Jun 15;73(12):3499-510. doi: 10.1158/0008-5472.CAN-13-0371. Epub 2013 Apr 16.
Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue. Sherwood AM, Emerson RO, Scherer D, Habermann N, Buck K, Staffa J, Desmarais C, Halama N, Jaeger D, Schirmacher P, Herpel E, Kloor M, Ulrich A, Schneider M, Ulrich CM, Robins H. Cancer Immunol Immun. 2013 Sep;62(9):1453-61. doi: 10.1007/s00262-013-1446-2. Epub 2013 Jun 16.
Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody. Krawczyk A, Arndt MA, Grosse-Hovest L, Weichert W, Giebel B, Dittmer U, Hengel H, Jaeger D, Schneweis KE, Eis-Huebinger AM, Roggendorf M, Krauss J. P Natl Acad Sci USA. 2013 Apr 23;110(17):6760-5. doi: 10.1073/pnas.1220019110. Epub 2013 Apr 8.
Re-resection for isolated local recurrence of pancreatic cancer is feasible, safe, and associated with encouraging survival. Strobel O, Hartwig W, Hackert T, Hinz U, Berens V, Grenacher L, Bergmann F, Debus J, Jaeger D, Buechler M, Werner J. Ann Surg Oncol. 2013 Mar;20(3):964-72. doi: 10.1245/s10434-012-2762-z. Epub 2012 Dec 12.
Successful treatment with nab-paclitaxel and gemcitabine after FOLFIRINOX failure in a patient with metastasized pancreatic adenocarcinoma. Berger AK, Weber TF, Jaeger D, Springfeld C. Onkologie. 2013;36(12):763-5. doi: 10.1159/000356811. Epub 2013 Nov 20.
Improvement of surgical results for pancreatic cancer. Hartwig W, Werner J, Jaeger D, Debus J, Buechler MW. Lancet Oncol. 2013 Oct;14(11):e476-85. doi: 10.1016/S1470-2045(13)70172-4.
Prognostic impact of lymph node involvement and the extent of lymphadenectomy (LAD) in adenocarcinoma of the esophagogastric junction (AEG). Sisic L, Blank S, Weichert W, Jaeger D, Springfeld C, Hochreiter M, Buechler M, Ott K. Langenbeck Arch Surg. 2013 Oct;398(7):973-81. doi: 10.1007/s00423-013-1101-6. Epub 2013 Jul 26.
New treatment strategies for multiple myeloma. Goldschmidt H, Nitschmann S. Internist. 2013 Jul;54(7):892-6. doi: 10.1007/s00108-013-3299-3.
Therapeutic strategies in multiple myeloma: the future role of bendamustine Goldschmidt H, Kropff M, Muegge LO, Poenisch W. Onkologie. 2013;36 Suppl 1:19-26. doi: 10.1159/000346107. Epub 2013 Jan 28.
New insights, recent advances, and current challenges in the biological treatment of multiple myeloma. Vallet S, Podar K. Expert Opin Biol Th. 2013 Jun;13 Suppl 1:S35-53. doi: 10.1517/14712598.2013.807337. Epub 2013 Jun 17. Review.
Multistage histopathological image segmentation of Iba1-stained murine microglias in a focal ischemia model: methodological workflow and expert validation. Valous NA, Lahrmann B, Zhou W, Veltkamp R, Grabe N. J Neurosci Meth. 213 (2013) 250-262. doi: 10.1016/j.jneumeth.2012.12.017.
Thalidomide maintenance therapy maturates the T-cell compartment and compromises antigen specific antitumor immunity in patients with multiple myeloma. Herth I, Witzens-Harig M, Beckhove P, Hose D, Meissner T, Neuber B, Engelhardt M, Haas J, Neben K, Ho AD, Klein B, Goldschmidt H, Hundemer M. Exp Hematol. 2013 Mar;41(3):231-40. doi: 10.1016/j.exphem.2012.10.018. Epub 2012 Nov 8.
Autologous retransplantation for patients with recurrent multiple myeloma: A single-center experience with 200 patients. Sellner L, Heiss C, Benner A, Raab MS, Hillengass J, Hose D, Lehners N, Egerer G, Ho AD, Goldschmidt H, Neben K. Cancer. 2013 Jul 1;119(13):2438-46. doi: 10.1002/cncr.28104. Epub 2013 Apr 10.
Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion. Munder M, Engelhardt M, Knies D, Medenhoff S, Wabnitz G, Luckner-Minden C, Feldmeyer N, Voss RH, Kropf P, Mueller I, Conradi R, Samstag Y, Theobald M, Ho AD, Goldschmidt H, Hundemer M. PLoS One. 2013 May 23;8(5):e63521
The glycome of normal and malignant plasma cells. Moehler TM, Seckinger A, Hose D, Andrulis M, Moreaux J, Hielscher T, Willhauck-Fleckenstein M, Merling A, Bertsch U, Jauch A, Goldschmidt H, Klein B, Schwartz-Albiez R. PLoS One. 2013 Dec 26;8(12):e83719. doi: 10.1371/journal.pone.0083719. eCollection 2013.
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Weinhold N, Johnson DC, Chubb D, Chen B, Foersti A, Hosking FJ, Broderick P, Ma YP, Dobbins SE, Hose D, Walker BA, Davies FE, Kaiser MF, Li NL, Gregory WA, Jackson GH, Witzens-Harig M, Neben K, Hoffmann P, Noethen MM, Muehleisen TW, Eisele L, Ross FM, Jauch A, Goldschmidt H, Houlston RS, Morgan GJ, Hemminki K. Nat Genet. 2013 May;45(5):522-5. doi: 10.1038/ng.2583. Epub 2013 Mar 17.
Proof of the concept to use a malignant B cell line drug screen strategy for identification and weight of melphalan resistance genes in multiple myeloma. Bøgsted M, Bilgrau AE, Wardell CP, Bertsch U, Schmitz A, Bødker JS, Kjeldsen MK, Goldschmidt H, Morgan GJ, Dybkaer K, Johnsen HE. PLoS One. 2013 Dec 20;8(12):e83252. doi: 10.1371/journal.pone.0083252. eCollection 2013.
Progression in smoldering myeloma Is independently determined by the chromosomal abnormalities del(17p), t(4;14), gain 1q, hyperdiploidy, and tumor load. Neben K, Jauch A, Hielscher T, Hillengass J, Lehners N, Seckinger A, Granzow M, Raab MS, Ho AD, Goldschmidt H, Hose D. J Clin Oncol. 2013 Dec 1;31(34):4325-32. doi: 10.1200/JCO.2012.48.4923. Epub 2013 Oct 21.
Preoperative therapy of esophagogastric cancer: the problem of nonresponding patients. Blank S, Stange A, Sisic L, Roth W, Grenacher L, Sterzing F, Burian M, Jaeger D, Buechler M, Ott K. Langenbeck Arch Surg. 2013 Feb;398(2):211-20. doi: 10.1007/s00423-012-1034-5. Epub 2012 Dec 7.
Factors predicting prognosis and recurrence in patients with esophago-gastric adenocarcinoma and histopathological response with less than 10 % residual tumor. Ott K, Blank S, Becker K, Langer R, Weichert W, Roth W, Sisic L, Stange A, Jaeger D, Buechler M, Siewert JR, Lordick F. Langenbeck Arch Surg. 2013 Feb;398(2):239-49. doi: 10.1007/s00423-012-1039-0. Epub 2012 Dec 27.
Rationing cancer care: a survey among the members of the german society of hematology and oncology. Krause SW, Schildmann J, Lotze Ch, Winkler EC. J Natl Compr Canc Netw. 2013 Jun 1;11(6):658-65.
The impact of patient and tumour baseline characteristics on the overall survival of patients with advanced hepatocellular carcinoma treated with sorafenib. Woerns MA, Koch S, Niederle IM, Marquardt JU, Nguyen-Tat M, Gamstaetter T, Schuchmann M, Schulze-Bergkamen H, Galle PR, Weinmann A. Digest Liver Dis. 2013 May;45(5):408-13. doi: 10.1016/j.dld.2012.10.010. Epub 2012 Nov 21.
Suppression of granzyme B activity and caspase-3 activation in leukaemia cells constitutively expressing the protease inhibitor 9. Fritsch K, Finke J, Gruellich C. Ann Hematol. 2013 Dec;92(12):1603-9. doi: 10.1007/s00277-013-1846-6. Epub 2013 Jul 28.
Neoadjuvant epirubicin, gemcitabine and docetaxel for primary breast cancer: long-term survival data and major prognostic factors based on two consecutive neoadjuvant phase I/II trials. Marmé F, Aigner J, Lorenzo Bermejo J, Sinn P, Sohn C, Jaeger D, Schneeweiss A. Int J Cancer. 2013 Aug 15;133(4):1006-15. doi: 10.1002/ijc.28094. Epub 2013 Mar 16.
Semantic Focusing Allows Fully Automated Single-Layer Slide Scanning of Cervical Cytology Slides. Lahrmann B, Valous NA, Eisenmann U, Wentzensen N, Grabe N. PloS One. 8(4): e61441. doi: 10.1371/journal.pone.0061441.
Hepatic metastases of colorectal cancer are rather homogeneous but differ from primary lesions in terms of immune cell infiltration. Halama N, Spille A, Lerchl T, Brand K, Herpel E, Welte S, Keim S, Lahrmann B, Klupp F, Kahlert C, Weitz J, Grabe N, Jaeger D, Zoernig I. OncoImmunology. 2:4, e24116; April 2013. doi: 10.4161/onci.24116.
Granulocyte-macrophage colony-stimulating factor-armed oncolytic measles virus is an effective therapeutic cancer vaccine. Grossardt C, Engeland CE, Bossow S, Halama N, Zaoui K, Leber MF, Springfeld C, Jaeger D, von Kalle C, Ungerechts G. Hum Gene Ther. 2013 Jul;24(7):644-54. doi: 10.1089/hum.2012.205.
Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. Koehler BC, Scherr AL, Lorenz S, Urbanik T, Kautz N, Elssner C, Welte S, Bermejo JL, Jaeger D, Schulze-Bergkamen H. PLoS One. 2013 Oct 3;8(10):e76446. doi: 10.1371/journal.pone.0076446. eCollection 2013.
CD24 polymorphisms in breast cancer: impact on prognosis and risk. Buck K, Hug S, Seibold P, Ferschke I, Altevogt P, Sohn C, Schneeweiss A, Burwinkel B, Jaeger D, Flesch-Janys D, Chang-Claude J, Marmé F. Breast Cancer Res Tr. 2013 Feb;137(3):927-37. doi: 10.1007/s10549-012-2325-9. Epub 2013 Jan 13.
Identification of oropharyngeal squamous cell carcinomas with active HPV16 involvement by immunohistochemical analysis of the retinoblastoma protein pathway. Holzinger D, Flechtenmacher C, Henfling N, Kaden I, Grabe N, Lahrmann B, Schmitt M, Hess J, Pawlita M, Bosch FX. Int J Cancer. 2013 Sep 15;133(6):1389-99. doi: 10.1002/ijc.28142. Epub 2013 Mar 29.
Diarrhea is a positive outcome predictor for sorafenib treatment of advanced hepatocellular carcinoma. Koschny R, Gotthardt D, Koehler C, Jaeger D, Stremmel W, Ganten TM. Oncology. 2013;84(1):6-13. doi: 10.1159/000342425. Epub 2012 Oct 13.
Sequential chemotherapies for advanced gastric cancer: a retrospective analysis of 111 patients. Elsing C, Herrmann C, Hannig CV, Stremmel W, Jaeger D, Herrmann T. Oncology. 2013;85(5):262-8. doi: 10.1159/000355690. Epub 2013 Oct 29.
Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy. Klug F, Prakash H, Huber PE, Seibel T, Bender N, Halama N, Pfirschke C, Voss RH, Timke C, Umansky L, Klapproth K, Schaekel K, Garbi N, Jaeger D, Weitz J, Schmitz-Winnenthal H, Haemmerling GJ, Beckhove P. Cancer Cell. 2013 Nov 11;24(5):589-602. doi: 10.1016/j.ccr.2013.09.014. Epub 2013 Oct 24.
Sequence mutations of the substrate binding pocket of stem cell factor and multidrug resistance protein ABCG2 in renal cell cancer: A possible link to treatment resistance. Zoernig I, Ziegelmeier C, Lahrmann B, Grabe N, Jaeger D, Halama N. Oncol Rep. 2013 May;29(5):1697-700. doi: 10.3892/or.2013.2324. Epub 2013 Mar 5.
Bridging the scales: semantic integration of quantitative SBML in graphical multi-cellular models and simulations with EPISIM and COPASI. Suetterlin T, Kolb C, Dickhaus H, Jaeger D, Grabe N. Bioinformatics. 2013 Jan 15;29(2):223-9. doi: 10.1093/bioinformatics/bts659. Epub 2012 Nov 18.
Urology in the concept of comprehensive cancer centers Hadaschik B, Pahernik S, Gruellich C, Sueltmann H, Jaeger D, von Kalle C, Duensing S, Hohenfellner M. Urologe A. 2013 Sep;52(9):1283-9. doi: 10.1007/s00120-013-3313-3.
B vitamin intakes and incidence of colorectal cancer: results from the Women's Health Initiative Observational Study cohort. Zschaebitz S, Cheng TY, Neuhouser ML, Zheng Y, Ray RM, Miller JW, Song X, Maneval DR, Beresford SA, Lane D, Shikany JM, Ulrich CM. Am J Clin Nutr. 2013 Feb;97(2):332-43. doi: 10.3945/ajcn.112.034736. Epub 2012 Dec 19.
High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance. Broyl A, Kuiper R, van Duin M, van der Holt B, El Jarari L, Bertsch U, Zweegman S, Buijs A, Hose D, Lokhorst HM, Goldschmidt H, Sonneveld P. Blood. 2013 Jan 24;121(4):624-7. doi: 10.1182/blood-2012-06-438101.
Sorafenib in patients with refractory or recurrent multiple myeloma. Yordanova A, Hose D, Neben K, Witzens-Harig M, Gütgemann I, Raab MS, Moehler T, Goldschmidt H, Schmidt-Wolf IG. Hematol Oncol. 2013 Dec;31(4):197-200. doi: 10.1002/hon.2043.
Prävention und Versorgung. Hrsg.: Kirch W, Hoffmann T, Pfaff H. Patientenorientierte Versorgungsforschung – Grundlagen, Methoden und Perspektiven. Ose D, Freund T, Winkler EC, Ludt S. ISBN 978-3-13-169451-5; 2012, S. 464-477. Verlag: Thieme, Stuttgart
Multiple myeloma – a new era of treatment strategies. Hrsg.: Podar K, Anderson KC. Guideline to multiple myeloma treatment strategies. Podar K, Kaufmann JL, Laubach J, Lonial S, Richardson PG, Anderson KC. ISBN: 978-1-60805-609-5. e-ISBN: 978-1-60805-297-4; 2012, S. 73-87. doi: 10.2174/97816080529741120101. Verlag: bentham science publishers
Multiple myeloma – a new era of treatment strategies. Hrsg.: Podar K, Anderson KC. New therapeutic strategies in multiple myeloma. Podar K, Hideshima T, Chauhan D, Anderson KC. ISBN: 978-1-60805-609-5. e-ISBN: 978-1-60805-297-4; 2012, S. 161-183. doi: 10.2174/97816080529741120101. Verlag: bentham science publishers
Multiple myeloma – a new era of treatment strategies. Hrsg.: Podar K, Anderson KC. Pathogenesis and treatment of bone disease in multiple myeloma. Vallet S, Raje N. ISBN: 978-1-60805-609-5. e-ISBN: 978-1-60805-297-4; 2012, S. 161-183. doi: 10.2174/97816080529741120101. Verlag: bentham science publishers
Rationelle Diagnostik und Therapie in der Inneren Medizin. Multiples Myelom. Goldschmidt H. ISBN: 978-3-437-22827-8; 2012, Bd. 11: S. 1-6. doi: - 06.
Onkologie 2012/2013. Interdisziplinäre Empfehlungen zur Therapie. Hrsg.: Preiß J, Dornoff W, Hagmann FG, Schmieder A. Multiples Myelom (MM, Plasmozytom). Goldschmidt H. ISBN: 978-3-86371-042-2; 2012, S. 57-61. doi: -. Verlag: W. Zuckschwerdt Verlag, München
Praxisbuch Ethik in der Intensivmedizin. Hrsg.: Salomon F. Die institutionelle moralische Verantwortung der Klinik. Winkler EC. ISBN: 978-3-941-46874-0; 2012, S. 123-129. doi: -. Verlag: Med. Wissenschaftliche Verlagsgesellschaft, Berlin
Journals
Deriving new treatment strategies. Podar K. Int J Hematol. 2012;1(1)1-6.
Targeting the tumor microenvironment: Focus on angiogenesis. Fan F, Schimming A, Jaeger D, Podar K. J Oncol. 2012;2012:281261. doi: 10.1155/2012/281261. Epub 2011 Aug 24.
MM-associated anemia: more than “crowding out” HSPCs. Podar K. Blood. 2012; Sep 27;120(13):2539-40.
Novel targets and derived small molecule inhibitors in multiple myeloma. Podar K. Curr Cancer Drug Tar. 2012 Sep;12(7):797-813.
GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo. Raab MS, Breitkreutz I, Anderhub S, Rønnest MH, Leber B, Larsen TO, Weiz L, Konotop G, Hayden PJ, Podar K, Fruehauf J, Nissen F, Mier W, Haberkorn U, Ho AD, Goldschmidt H, Anderson KC, Clausen MH, Kraemer A. Cancer Res. 2012 Oct 15;72(20):5374-85. doi: 10.1158/0008-5472.CAN 12-2026. Epub 2012 Aug 31.
Development of gene expression based score to predict sensitivity of multiple myeloma cells to DNA methylation inhibitors Moreaux J, Rème T, Leonard W, Veyrune JL, Requirand G, Goldschmidt H, Hose D, Klein B. Mol Cancer Ther. 2012 Dec;11(12):2685-92. doi: 10.1158/1535-7163.MCT-12-0721. Epub 2012 Oct 18.
Identification of pluripotent and adult stem cell genes unrelated to cell cycle and associated with poor prognosis in multiple myeloma. Kassambara A, Hose D, Moreaux J, Rème T, Torrent J, Rossi JF, Goldschmidt H, Klein B. PLoS One. 2012;7(7):e42161. doi: 10.1371/journal.pone.0042161. Epub 2012 Jul 31.
Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: results of the randomized phase III HOVON-65/ GMMG-HD4 trial. Sonneveld P, Schmidt-Wolf IG, van der Holt B, El Jarari L, Bertsch U, Salwender H, Zweegman S, Vellenga E, Broyl A, Blau IW, Weisel KC, Wittebol S, Bos GM, Stevens-Kroef M, Scheid C, Pfreundschuh M, Hose D, Jauch A, van der Velde H, Raymakers R, Schaafsma MR, Kersten MJ, van Marwijk-Kooy M, Duehrsen U, Lindemann W, Wijermans PW, Lokhorst HM, Goldschmidt HM. J Clin Oncol. 2012 Aug 20;30(24):2946-55. doi: 10.1200/JCO.2011.39.6820. Epub 2012 Jul 16. Erratum in: J Clin Oncol. 2012 Oct 10;30(29):3654.
A gene expression signature for high-risk multiple myeloma. Kuiper R, Broyl A, de Knegt Y, van Vliet MH, van Beers EH, van der Holt B, el Jarari L, Mulligan G, Gregory W, Morgan G, Goldschmidt H, Lokhorst HM, van Duin M, Sonneveld P. Leukemia. 2012 Nov;26(11):2406-13. doi: 10.1038/leu.2012.127. Epub 2012 May 8. Erratum in: Leukemia. 2014 May;28(5):1178-80.
Clinical and prognostic role of annexin A2 in multiple myeloma. Seckinger A, Meißner T, Moreaux J, Depeweg D, Hillengass J, Hose K, Rème T, Roesen-Wolff A, Jauch A, Schmettler R, Ewerbeck V, Goldschmidt H, Klein B, Hose D. Blood. 2012 Aug 2;120(5):1087-94. doi: 10.1182/blood-2012-03-415588. Epub 2012 Jun 15.
Changes in magnetic resonance imaging before and after autologous stem cell transplantation correlate with response and sdurvival in multiple myeloma. Hillengass J, Ayyaz S, Kilk K, Weber MA, Hielscher T, Shah R, Hose D, Delorme S, Goldschmidt H, Neben K. Haematologica. 2012 Nov;97(11):1757-60. doi: 10.3324/haematol.2012.065359. Epub 2012 Jun 11.
Treatment with lenalidomide and dexamethasone in patients with multiple myeloma and renal impairment. Dimopoulos MA, Terpos E, Goldschmidt H, Alegre A, Mark T, Niesvizky R. Cancer Treat Rev. 2012 Dec;38(8):1012-9. doi: 10.1016/j.ctrv.2012.02.009. Epub 2012 May 18. Review.
Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMEnSE consortium. Campa D, Martino A, Sainz J, Buda G, Jamroziak K, Weinhold N, Vieira Reis RM, García-Sanz R, Jurado M, Ríos R, Szemraj-Rogucka Z, Marques H, Lesueur F, Bugert P, Moreno V, Szemraj J, Orciuolo E, Gemignani F, Rossi AM, Dumontet C, Petrini M, Goldschmidt H, Landi S, Canzian F. Br J Haematol. 2012 May;157(3):331-8. Epub 2012 Feb 13.
European perspective on multiple myeloma treatment strategies: update following recent congresses. Ludwig H, Avet-Loiseau H, Bladé J, Boccadoro M, Cavenagh J, Cavo M, Davies F, de la Rubia J, Delimpasi S, Dimopoulos M, Drach J, Einsele H, Facon T, Goldschmidt H, Hess U, Mellqvist UH, Moreau P, San-Miguel J, Sondergeld P, Sonneveld P, Udvardy M, Palumbo A. Oncologist. 2012;17(5):592-606. doi: 10.1634/theoncologist.2011-0391. Epub 2012 May 9.
Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma. Wolf JL, Siegel D, Goldschmidt H, Hazell K, Bourquelot PM, Bengoudifa BR, Matous J, Vij R, de Magalhaes-Silverman M, Abonour R, Anderson KC, Lonial S. Leukemia Lymphoma. 2012 Sep;53(9):1820-3. doi: 10.3109/10428194.2012.661175. Epub 2012 Mar 1.
Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and multiple myeloma risk: a case-control study in the context of the International Multiple Myeloma research (IMMEnSE) consortium. Martino A, Campa D, Buda G, Sainz J, García-Sanz R, Jamroziak K, Reis RM, Weinhold N, Jurado M, Ríos R, Szemraj-Rogucka Z, Marques H, Szemraj J, Stein A, Kumar R, Orciuolo E, Gemignani F, Landi S, Goldschmidt H, Petrini M, Dumontet C, Canzian F, Rossi AM. Leukemia. 2012 Jun;26(6):1419-22. doi: 10.1038/leu.2011.352. Epub 2011 Dec 20.
Administration of bortezomib before and after autologous stem-cell transplantation improves outcome in multiple myeloma patients with deletion 17p. Neben K, Lokhorst HM, Jauch A, Bertsch U, Hielscher T, van der Holt B, Salwender H, Blau IW, Weisel K, Pfreundschuh M, Scheid C, Duehrsen U, Lindemann W, Schmidt-Wolf IG, Peter N, Teschendorf C, Martin H, Haenel M, Derigs HG, Raab MS, Ho AD, van de Velde H, Hose D, Sonneveld P, Goldschmidt H. Blood. 2012 Jan 26;119(4):940-8. doi: 10.1182/blood-2011-09-379164. Epub 2011 Dec 8.
Parametric histogram analysis of dynamic contrast-enhanced MRI in multiple myeloma a technique to evaluate angiogenic response to therapy? Zechmann CM, Traine L, Meißner T, Wagner-Gund B, Giesel FL, Goldschmidt H, Delorme S, Hillengass J. Acad Radiol. 2012 Jan;19(1):100-8. doi: 10.1016/j.acra.2011.09.007.
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. Broderick P, Chubb D, Johnson DC, Weinhold N, Foersti A, Lloyd A, Olver B, Ma YP, Dobbins SE, Walker BA, Davies FE, Gregory WA, Child JA, Ross FM, Jackson GH, Neben K, Jauch A, Hoffmann P, Muehleisen TW, Noethen MM, Moebus S, Tomlinson IP, Goldschmidt H, Hemminki K, Morgan GJ, Houlston RS. Nat Genet. 2011 Nov 27;44(1):58-61. doi: 10.1038/ng.993.
Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma. Kassambara A, Hose D, Moreaux J, Walker BA, Protopopov A, Reme T, Pellestor F, Pantesco V, Jauch A, Morgan G, Goldschmidt H, Klein B. Haematologica. 2012 Apr;97(4):622-30. doi: 10.3324/haematol.2011.046821. Epub 2011 Nov 18.
MAGIC (MyelomA Genetics International Consortium). Morgan G, Johnsen HE, Goldschmidt H, Palumbo A, Cavo M, Sonneveld P, Miguel JS, Chim CS, Browne P, Einsele H, Waage A, Turesson I, Spencer A, Hajek R, Ludwig H, Hemminki K, Houlston R. Leuk Lymphoma. 2012 May;53(5):796-800. doi: 10.3109/10428194.2011.639881. Epub 2012 Jan 3.
Meeting report of the third Heidelberg myeloma workshop: current status and developments in diagnosis and therapy of multiple myeloma. Hillengass J, Neben K, Goldschmidt H. J Cancer Res Clin. 2012 Jan;138(1):173-8. doi: 10.1007/s00432-011-1071-4. Epub 2011 Sep 30.
Update on immunomodulatory drugs (IMiDs) in hematologic and solid malignancies. Vallet S, Witzens-Harig M, Jaeger D, Podar K. Expert Opin Pharmaco. 2012 Mar;13(4):473-94. doi: 10.1517/14656566.2012.656091. Epub 2012 Feb 13.
Open-label, multicenter, randomized phase III trial of adjuvant chemoradiation plus interferon Alfa-2b versus fluorouracil and folinic acid for patients with resected pancreatic adenocarcinoma. Schmidt J, Abel U, Debus J, Harig S, Hoffmann K, Herrmann T, Bartsch D, Klein J, Mansmann U, Jaeger D, Capussotti L, Kunz R, Buechler MW. J Clin Oncol. 2012 Nov 20;30(33):4077-83. doi: 10.1200/JCO.2011.38.2960. Epub 2012 Sep 24.
Eine ethische Orientierungshilfe: Therapieverzicht gegen den Patientenwillen? Winkler EC, Marckmann G. ÄBW. (4) 2012:140-144.
Aenderung des Therapieziels am Lebensende: Effekte einer Klinik-Leitlinie. Jox RJ, Winkler EC, Borasio GD. Deut Med Wochenschr. 2012; 137(16):829-833.
Evaluating a patient’s request for life-prolonging treatment: an ethical framework. Winkler EC, Hiddemann W, Marckmann G. J Med Ethics. 2012 Nov;38(11):647-51. doi: 10.1136/medethics-2011-100333. Epub 2012 Jun 12.
Interdisziplinaere Therapiekonzepte bei kolorektalen Lebermetastasen. Schulze-Bergkamen H, Jaeger D. Viszeralmedizin. 2012 (28):43-49.
Liver specific deletion of CYLDexon 7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice. Urbanik T, Boger RJ, Longerich T, Becker K, Ehrenberg KR, Hoevelmeyer N, Hahn M, Schuchmann M, Jaeger D, Waisman A, Woerns MA, Schulze-Bergkamen H. J Hepatol. 2012 Nov;57(5):995-1003. doi: 10.1016/j.jhep.2012.06.017. Epub 2012 Jun 21.
Chemovirotherapy for head and neck squamous cell carcinoma with EGFR-targeted and CD/UPRT-armed oncolytic measles virus. Zaoui K, Bossow S, Grossardt C, Leber MF, Springfeld C, Plinkert PK, Kalle CV, Ungerechts G. Cancer Gene Ther. 2012 Mar;19(3):181-91. doi: 10.1038/cgt.2011.75. Epub 2011 Nov 11.
Emerging trends in oncology testing: enhancing the medical value of diagnostics. Rohr UP, Walk E, Teichgraeber V, Liesenfeld O, Batria R, Lee JA. Clpmag.com. 2012 42(9):8-13
Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins. Enkirch T, Kneissl S, Hoyler B, Ungerechts G, Stremmel W, Buchholz CJ, Springfeld C. Gene Ther. 2013 Jan;20(1):16-23. doi: 10.1038/gt.2011.209. Epub 2012 Jan 5.
Broadly neutralizing immune responses against hepatitis C virus induced by vectored measles viruses and a recombinat envelope protein booster. Reyes-del Valle J, de la Fuente C, Turner MA, Springfeld C, Apte-Sengupta S, Frenzke ME, Forest A, Whidby J, Marcotrigiano J, Rice CM, Cataneo R. J Virol. 2012 Nov;86(21):11558-66. doi: 10.1128/JVI.01776-12. Epub 2012 Aug 15.
Kyphoplasty in patients with multiple myeloma a retrospective comparative pilot study. Kasperk C, Haas A, Hillengass J, Weiss C, Neben K, Goldschmidt H, Sommer U, Nawroth P, Meeder PJ, Wiedenhoefer B, Schmidmaier G, Tanner M, Neuhof D, Noeldge G, Grafe IA. J Surg Oncol. 2012 Jun 1;105(7):679-86. doi: 10.1002/jso.22101. Epub 2011 Sep 29.
Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study. Kumar SK, Lee JH, Lahuerta JJ, Morgan G, Richardson PG, Crowley J, Haessler J, Feather J, Hoering A, Moreau P, LeLeu X, Hulin C, Klein SK, Sonneveld P, Siegel D, Bladé J, Goldschmidt H, Jagannath S, Miguel JS, Orlowski R, Palumbo A, Sezer O, Rajkumar SV, Durie BG; International myeloma working group study. Leukemia. 2012 Jan;26(1):149-57. doi: 10.1038/leu.2011.196. Epub 2011 Jul 29.
The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications. Podar K, Zimmerhackl A, Fulciniti M, Tonon G, Hainz U, Tai YT, Vallet S, Halama N, Jaeger D, Olson DL, Sattler M, Chauhan D, Anderson KC. Brit J Haematol. 2011 Nov;155(4):438-48. doi: 10.1111/j.1365-2141.2011.08864.x. Epub 2011 Sep 19.
5-Fluorouracil and interferon-α immunochemotherapy enhances immunogenicity of murine pancreatic cancer through upregulation of NKG2D ligands and MHC class I. Khallouf H, Maerten A, Serba A, Teichgraeber V, Buechler MW, Jaeger D, Schmidt J. J Immunother. 2012 Apr;35(3):245-53. doi: 10.1097/CJI.0b013e31824b3a76.
A phase II study for metabolic in vivo response monitoring with sequential 18FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer: the Heidelberg REMOTUX trial. Berger AK, von Gall C, Abel U, Delorme S, Kloor M, Ose J, Weber TF, Stange A, Haag GM, Haberkorn U, Lordick F, Jaeger D. BMC Cancer. 2012 Mar 22;12:108. doi: 10.1186/1471-2407-12-108.
Phase I/II trial evaluating carbon ion radiotherapy for the treatment of recurrent rectal cancer: the PANDORA-01 trial. Combs SE, Kieser M, Habermehl D, Weitz J, Jaeger D, Fossati P, Orrechia R, Engenhart-Cabillic R, Poetter R, Dosanjh M, Jaekel O, Buechler MW, Debus J. BMC Cancer. 2012 Apr 3;12:137. doi: 10.1186/1471-2407-12-137.
Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS--a randomised controlled multicentre trial (ISRCTN30964555). Rahbari NN, Lordick F, Fink C, Bork U, Stange A, Jaeger D, Luntz SP, Englert S, Rossion I, Koch M, Buechler MW, Kieser M, Weitz J; SYNCHRONOUS trial group. BMC Cancer. 2012 Apr 5;12:142. doi: 10.1186/1471-2407-12-142.
Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice. Urbanik T, Boger RJ, Longerich T, Becker K, Ehrenberg KR, Hoevelmeyer N, Hahn M, Schuchmann M, Jaeger D, Waisman A, Woerns MA, Schulze-Bergkamen H. J Hepatol. 2012 Nov;57(5):995-1003. doi: 10.1016/j.jhep.2012.06.017. Epub 2012 Jun 21.
Resection after neoadjuvant therapy for locally advanced, "unresectable" pancreatic cancer. Strobel O, Berens V, Hinz U, Hartwig W, Hackert T, Bergmann F, Debus J, Jaeger D, Buechler MW, Werner J. Surgery. 2012 Sep;152(3 Suppl 1):S33-42. doi: 10.1016/j.surg.2012.05.029. Epub 2012 Jul 6.
Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy. Kahlert C, Gaitzsch E, Steinert G, Mogler C, Jansen L, Benner A, Chang-Claude J, Klupp F, Schmidt T, Grabe N, Lahrmann B, Halama N, Weitz J. Ann Surg Oncol. 2012 Dec;19(13):4193-201. doi: 10.1245/s10434-012-2518-9. Epub 2012 Aug 10.
The local immunological microenvironment in colorectal cancer as a prognostic factor for treatment decisions in the clinic: The way ahead. Halama N, Zoernig I, Grabe N, Jaeger D. Oncoimmunology. 2012 Jan 1;1(1):62-66.
Sequential metastases of colorectal cancer. Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments. Keim S, Zoernig I, Spille A, Lahrmann B, Brand K, Herpel E, Grabe N, Jaeger D, Halama N. Oncoimmunology. 2012 Aug 1:5,593-599.
Cationic liposomal paclitaxel plus gemcitabine or gemcitabine alone in patients with advanced pancreatic cancer: a randomized controlled phase II trial. Loehr JM, Haas SL, Bechstein WO, Bodoky G, Cwiertka K, Fischbach W, Foelsch UR, Jaeger D, Osinsky D, Prausova J, Schmidt WE, Lutz MP; CT4001 Study Group. Ann Oncol. 2012 May;23(5):1214-22. doi: 10.1093/annonc/mdr379. Epub 2011 Sep 6.
Multistage histopathological image segmentation of Iba1-stained murine microglias in a focal ischemia model: Methodological workflow and expert validation. Valous NA, Lahrmann B, Zhou W, Veltkamp R, Grabe N. J Neurosci Meth. 213 (2013) 250-262. doi: 10.1016/j.jneumeth.2012.12.017.
Bridging the scales: semantic integration of quantitative SBML in graphical multi-cellular models and simulations with EPISIM and COPASI Suetterlin T, Kolb C, Dickhaus H, Jaeger D, Grabe N. Bioinformatics.2013 Jan 15;29(2):223-9. doi: 10.1093/bioinformatics/bts659.Epub 2012 Nov 18.
Revisiting the training of logic models of protein signaling networks with ASP. Videla S, Guziolowski C, Eduati F, Thiele S, Grabe N, Saez-Rodriguez J, Siegel A. Computational Methods in Systems Biology. Series: Lecture Notes in Computer Science. 2012 Vol 7605:342-361.
Submaxillary gland androgen-regulated protein 3A expression is an unfavorable risk factor for the survival of oropharyngeal squamous cell carcinoma patients after surgery. Koffler J, Holzinger D, Sanhueza GA, Flechtenmacher C, Zaoui K, Lahrmann B, Grabe N, Plinkert PK, Hess J. Eur Arch Oto-Rhino-L. 2012 05. October 2012; doi: 10.1007/s00405-012-2201-6.
Potential canonical Wnt pathway activation in high-grade astrocytomas Schuele R, Dictus C, Campos B, Wan F, Felsberg J, Ahmadi R, Centner F, Grabe N, Reifenberger G, Bermejo J, Unterberg A, Herold-Mende C. The Scientific World Journal. 2012:697313. doi: 10.1100/2012/697313. Epub 2012 Aug 2.
In silico accelerated identification of structurally conserved CD8+ and CD4+ T-cell epitopes in high-risk HPV types. Gupta SK, Srivastava M, Akhoon BA, Gupta SK, Grabe N. Infect Genet Evol. 2012 Oct;12(7):1513-8. doi: 10.1016/j.meegid.2012.02.022. Epub 2012 May 24.
Automatic generation of causal networks linking growth factor stimuli to functional cell state changes. Guziolowski C, Kittas A, Dittmann F, Grabe N. FEBS J. 2012 Sep;279(18):3462-74. doi: 10.1111/j.1742-4658.2012.08616.x. Epub 2012 May 22.
Radiochemoimmunotherapy with intensity-modulated concomitant boost: interim analysis of the REACH trial. Jensen AD, Krauss J, Potthoff K, Simon C, Nikoghosyan AV, Lossner K, Debus J, Munter MW. Radiat Oncol. 2012 Apr 2;7:57. doi: 10.1186/1748-717X-7-57.
Phase II study of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients with locally advanced or metastatic pancreatic cancer. Strumberg D, Schultheis B, Scheulen ME, Hilger RA, Krauss J, Marschner N, Lordick F, Bach F, Reuter D, Edler L, Mross K. Invest New Drug. 2012 Jun;30(3):1138-43. doi: 10.1007/s10637-010-9619-8. Epub 2010 Dec 21.
Fulminant liver failure in Wilson's disease with histologic features of postinfantile giant cell hepatitis; cytomegalovirus as the trigger for both? Welte S, Gagesch M, Weber A, Longerich T, Millonig G. Eur J Gastroenterol Hepatol. 2012 Mar;24(3):328-31. doi: 10.1097/MEG.0b013e3283506843.
