Practical Achievements

• EURAT project group „Ethical and Legal Aspects of Translational Medicine”:
  Position Paper: Cornerstones for an ethically and legally informed practice of Whole Genome Sequencing: Code of Conduct and patient consent models.
• EURAT project group „Ethical and Legal Aspects of Translational Medicine”:
  Position Paper: On the Release of Raw Genomic Data to Patients and Study Participants.
• Guideline for advanced care planning and limiting treatment on changing and communicating the goal of care from curative to palliative.
• Jungkunz M, Köngeter A, Spitz M, Mehlis K, Cornelius K, Schickhardt C, Winkler EC (2022): Stellungnahme zur Etablierung der sekundären Forschungsnutzung von Behandlungsdaten in Deutschland. Ergebnisse des Verbundprojekts LinCDat: „Learning from Clinical Data. Ethical, Social and Legal Aspects". Forum Marsilius Kolleg, 21: 1-123.
• EURAT project group "Ethical and Legal Aspects of Translational Medicine":
  Position paper on the return of additional genetic findings in minors

Publications

1. Research Ethics

• Köngeter A, Schickhardt C, Jungkunz M, Bergbold S, Mehlis K, Winkler EC. Patients’ willingness to provide their clinical data for research purposes and acceptance of different consent models: Findings from a representative survey of cancer patients in Germany. J Med Internet Res, 2022; 24(8): e37665.https://doi.org/10.2196/37665
• Winkler EC, Knoppers BM. Ethical challenges of precision cancer medicine. Semin Cancer Biol. 2022; 84: 263-270. Epub 2020 Oct 9.
  https://doi.org/10.1016/j.semcancer.2020.09.009
• Zenker S, Strech S, Ihrig K, Jahns R, Müller G, Schickhardt C, Schmidt G, Speer R, Winkler EC, Graf von Kielmansegg S, Drepper J. Data protection-compliant broad consent for secondary use of health care data and human biosamples for (bio)medical research: Towards a new German national standard. J Biomed Inform. 2022; 131: 104096.https://doi.org/10.1016/j.jbi.2022.104096
• Alex K, Winkler EC. Ethischer Diskurs zu Epigenetik und Genom-Editierung: die Gefahr eines (epi-)genetischen Determinismus und naturwissenschaftlich strittiger Grundannahmen. In: Fehse B, …, Winkler EC, Zenke M. Fünfter Gentechnologiebericht. Forschungsberichte der interdisziplinären Arbeitsgruppen der Berlin-Brandenburgischen Akademie der Wissenschaften Baden-Baden: Nomos Verlagsgesellschaft. 2021; 44: 13: 299-323.https://doi.org/10.5771/9783748927242
• Rehm HL, …, Winkler EC, …, North K, Birney E. GA4GH: International policies and standards for data sharing across genomic research and healthcare. Cell Genomics, 2021, 1, 2: 100029.https://doi.org/10.1016/j.xgen.2021.100029
• Winkler EC, Idler I, Beck K, Brors B, Cornelius K, Dikow N, Fleischer H, Fröhling S, Glimm H, Herpel E, Korbel J, Lichter P, Richter D, Schickhardt C, Tanner K, Wiemann S. On the Release of Raw Genomic Data to Patients and Study Participants. Position paper of the EURAT project group “Ethical and Legal Aspects of Whole Genome Sequencing”. Forum Marsilius Kolleg, 2020:https://doi.org/10.11588/fmk.2020.0.76125
   

2. Clinical Ethics

• Schildmann J, Junghanss C, Oldenburg M, Schuler U, Trümper L, Wörmann B, Winkler EC. Role and responsibility of oncologists in assisted suicide. Practice and views among members of the German Society of Haematology and Medical Oncology. ESMO Open. 2021; 6(6): 100329.https://doi.org/10.1016/j.esmoop.2021.100329
• Mehlis K, Bierwirth E, Laryionava K, Mumm F, Heußner P, Winkler EC. Late decisions about treatment limitation in patients with cancer: empirical analysis of end-of-life practices in a haematology and oncology unit at a German university hospital. ESMO Open. 2020; 5 (5): e000950.https://doi.org/10.1136/esmoopen-2020-000950
   

3. Health Policy

• Eckford ED, Gaisser A, Arndt V, Baumann M, Kludt E, Mehlis K, Ubels J, Winkler EC, Weg-Remers S, Schlander M. The COVID-19 Pandemic and Cancer Patients in Germany: Impact on Treatment, Follow-up Care and Psychological Burden. Front Public Health. 2022; 9: 788598. https://doi.org/10.3389/fpubh.2021.788598
• Pauge S, Surmann B, Mehlis K, Zueger A, Richter L, Menold N, Greiner W, Winkler EC. Patient-Reported Financial Distress in Cancer: A Systematic Review of Risk Factors in Universal Healthcare Systems. Cancers. 2021; 13(19): 5015.https://doi.org/10.3390/cancers13195015

Funding

• German CancerAid - Deutsche Krebshilfe e.V.
• German Ministryfor Education and Research (Bundesministerium für Bildung und Forschung)
• Early Clinical development Research (DKFZ)
• Marsilius-Kolleg (Initiative of Excellence)
• Deutsche Forschungsgemeinschaft e.V. (DFG)

Honors and Awards

• Walter Siegenthaler Preis 2017 der Deutschen Medizinischen Wochenschrift (5.000 €):
  Mehlis K, Becker C, Christ C, Laryionava K, Hiddemann W, Heußner P, Winkler EC. „Entscheidungspraxis zur Therapiebegrenzung (TBE) am Lebensende in der hämatologisch/ onkologischen Universitätsklinik. Empirische Baseline-Erhebung der leitliniengestützten Interventionsstudie zur Verbesserung von Entscheidungen zur Therapiebegrenzung“
• Lohfert Prize 2016 (20.000 €) for the EPAL-project: Heußner P, Winkler EC. “Treatment limitation: improvement of shared decision-making with cancer patients“
  » Lohfert-Preis 2016: Portrait des Preisträgers (YouTube)
• Best Poster Award: Laryionava K, Sklenarova H, Heußner P, Hartmann M, Winkler EC. “Decision Making in Oncology at the End of Life: Patient’s Preferences for Quality or Length of Life.” Ethics and Evidence in end-of-life decision making - Interdisciplinary Perspectives. 3. -4. April 2014, Bochum, Deutschland
• Roche Faculty Award (10.000 SFR) for the best dissertation 2010, University of Basel, Switzerland: Winkler EC. “Challenges at the End of Life: Involving Patients and Family Members in Decisions Concerning the Determination of Medical Care”