Clinical Trials

Head- and Neck Tumors

Recruitment stopped
Ongoing Recruitment

BMS CA209-651

(first-line)
Title:An Open Label, Randomized, Two Arm Phase III Study of Nivolumab in Combination With Ipilimumab Versus Extreme Study Regimen (Cetuximab + Cisplatin/Carboplatin + Fluorouracil) as First Line Therapy in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Indication:Carcinoma, Squamous Cell, Head and Neck Neoplasms
Type of study:Phase III
Contact: Ulrike Boose (Kontaktperson)
[Ulrike.Boose@med.uni-heidelberg.de]
Investigator: Dr. med. Jutta Sylvina Schreiber (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02741570
EudraCT: 2016-000725-39 (siehe EU klinisches Studienregister)

NCT-PMO-1603 TOP-ART

(second-line, BRCAness)
Title:A Randomized Phase-2 Study of Trabectedin/Olaparib Compared to Physician's Choice in Subjects With Previously Treated Advanced or Recurrent Solid Tumors Harboring DNA Repair Deficiencies
Indication:DNA Repair-Deficiency Disorders
Type of study:Phase II
Contact: Barbara Stöhr (Study Nurse)
[barbara.stoehr@nct-heidelberg.de]
Investigator: Prof. Dr. Stefan Fröhling (Leiter klinische Prüfung)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03127215
EudraCT: 2017-001755-31 (siehe EU klinisches Studienregister)

LINGUA

(epidemiologisch)
Title:Identifikation von Kompensationsmechanismen zum Erhalt von Sprechen und Schlucken nach kombiniert ablativ/rekonstruktiven Operationen in der Mund-, Kiefer- und Gesichtschirurgie
Indication:Larynx
Type of study:Phase N/A
Contact: Regina Männl (Study Nurse)
[Regina.Maennl@med.uni-heidelberg.de]
Investigator: Dr. Dr. Katinka Kansy (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

PROCURE

(epidemiologisch)
Title:Prospektive Untersuchung zur Rezidivfreiheit und Lebensqualität bei frühen Mundhöhlenkarzinomen nach chirurgischer Therapie mit mikrovaskulärer Rekonstruktion (PROCURE)
Indication:Stoma Pharynx (C00, C01, C02, C03, C04, C05, C06, C07, C08, C09, C10, C11, C12, C13, C14)
Type of study:Phase N/A
Contact: Regina Männl (Study Nurse)
[Regina.Maennl@med.uni-heidelberg.de]
Investigator: Dr. Julius Moratin (Prüfer)
Trial Register: Die Studie ist beim "DRKS - Deutsches Register Klinischer Studien" registriert. Siehe DRKS00013041
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

PROSS

(epidemiologisch, chirurgisch)
Title:Prospektive Untersuchungen zur rettungschirurgischen Therapie (Salvage Surgery) des Mundhöhlenkarzinoms (PROSS)
Indication:Mundhöhlenkarzinom
Type of study:Phase N/A
Contact: Regina Männl (Study Nurse)
[Regina.Maennl@med.uni-heidelberg.de]
Investigator: Dr. med. Dr. med. dent. Jens Bodem (Prüfer)
Trial Register: Die Studie ist beim "DRKS - Deutsches Register Klinischer Studien" registriert. Siehe DRKS00009255
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Sono-Studie

(radiologisch, supportive care trial)
Title:Einfluss einer Strahlentherapie auf die extrakraniellen Halsgefäße bei Patienten mit Kopf-Hals-Tumoren
Indication:Kopf-Hals-Tumoren
Type of study:Phase N/A
Contact: Ines Ludwig (Kontaktperson)
[Ines.Ludwig@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Oliver Müller (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

CV-8102-008

Title:Phase I Study of Intratumoral CV8102 in Patients With Advanced Melanoma, Squamous Cell Carcinoma of the Skin, Squamous Cell Carcinoma of the Head and Neck, or Adenoid Cystic Carcinoma
Indication:Carcinoma, Melanoma, Carcinoma, Squamous Cell, Skin Neoplasms, Head and Neck Neoplasms, Carcinoma, Adenoid Cystic
Type of study:Phase I
Contact: Sebastian Schülke (Study Nurse)
[Sebastian.Schuelke@med.uni-heidelberg.de]
Investigator: PD Dr. med. Jürgen Krauss (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03291002
EudraCT: 2016-003429-41 (siehe EU klinisches Studienregister)

HIPO/POP- Teil 2

Title:Prospective study on head and neck squamous cell carcinoma patients to elucidate molecular mechanisms of treatment failure
Indication:Plattenepithelkarzinom des Kopf-Hals-Bereiches
Type of study:Phase N/A
Contact: Prof. Dr. Jochen Heß (Kontaktperson)
[Jochen.Hess@med.uni-heidelberg.de]
Investigator: Dr. Karim Zaoui (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

S-229/216

Title:hypothesengenerierende Pilotstudie
Indication:-
Type of study:Phase N/A
Contact: Dr. med. Henrik Hauswald (Kontaktperson)
[henrik.hauswald@med.uni-heidelberg.de]
Investigator: Dr. med. Henrik Hauswald (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

STARTRK-2/ RXDX-101-92

Title:AN OPEN-LABEL, MULTICENTER, GLOBAL PHASE 2 BASKET STUDY OF ENTRECTINIB FOR THE TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS THAT HARBOR NTRK1/2/3, ROS1, OR ALK GENE REARRANGEMENTS
Indication:Locally Advanced or Metastatic Solid Tumors that Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Type of study:Phase II
Contact: Stefanie Hofmann (Study Nurse)
[stefanie.hofmann@med.uni-heidelberg.de]
Investigator: Dr. med. Christoph Springfeld (Prüfer)
Trial Register: No trial registry number given.
EudraCT: 2015-003385-84 (siehe EU klinisches Studienregister)

Vaccibody (VBN-01)

Title:An open labelled first human dose phase 1/2a study to evaluate safety, feasibility and efficacy of multiple dosing with individualised VB10.NEO immunotherapy in patients with locally advanced or metastatic melanoma, NSCLC, clear renal cell carcinoma, urothelial cancer or squamous cell carcinoma of head and neck, who did not reach complete responses with current standard of care immune checkpoint blockade
Indication:Locally advanced or metastatic solid tumours including melanoma, NSCLC, clear renal cell carcinoma, urothelial cancer or SCCHN
Type of study:Phase I
Contact: Sebastian Schülke (Kontaktperson)
[Sebastian.Schuelke@med.uni-heidelberg.de]
Investigator: PD Dr. med. Jürgen Krauss (Leiter klinische Prüfung)
Trial Register: No trial registry number given.
EudraCT: 2017-002474-39 (siehe EU klinisches Studienregister)