Prof. Hermann Brenner, head of the DKFZ Division of Clinical Epidemiology and Aging Research, serves as temporary head of the Division Preventive Oncology since November 2014. Under his leadership, a research agenda focusing on novel avenues of cancer screening and early detection is currently being built up. Two major studies within the framework of the NCT 3.0 program will start in 2016: the GEKKO study (study start 01/2016) and the DARIO study (study start 09/2016). A second research focus on risk adapted prevention will be developed for the future.