Clinical Trials

Thoracical Tumors

Recruitment stopped
Ongoing Recruitment

CINC wt-Studie (Novartis CINC280A2201)

(second-line)
Title:A Phase II, Multicenter, Three-cohort Study of Oral cMET Inhibitor INC280 in Adult Patients With EGFR Wild-type (wt), Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Received One or Two Prior Lines of Systemic Therapy for Advanced/Metastatic Disease
Indication:Carcinoma, Non-Small-Cell Lung
Type of study:Phase II
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Michael Thomas (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02414139
EudraCT: 2014-003850-15 (siehe EU klinisches Studienregister)

BioNTech –Forschungsstudie (RB_T002)

(diagnostisch, Früherkennung, Screening)
Title:Identifikation von individuellen Krebsmutationen und Testung ihrer Immunogenität
Indication:-
Type of study:Phase N/A
Contact: Anette Manka-Stuhlik (Kontaktperson)
[anette.manka-stuhlik@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Dirk Jäger (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

PET-CT__PET-MRT bei Bronchialkarziom

(diagnostisch, Screening)
Title:Vergleich der diagnostischen Genauigkeit von FDG-PET/CT und FDG-PET/MRT einschließlich Diffusionsgewichteter MRT beim präoperativen Staging von Patienten mit Nicht-kleinzelligem Bronchialkarzinom.
Indication:Bronchialkarziom
Type of study:Phase N/A
Contact: Radiologie, DKFZ (E10) (Kontaktperson)
[-]
Investigator: Prof. Dr. Heinz-Peter Schlemmer (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

INKA-Studie

(radiologisch)
Title:Ionentherapie bei nicht-kleinzelligen Pancoast-Tumoren im trimodalen Behandlungskonzept: Die INKA-Studie
Indication:Nicht-kleinzellige Pancoast-Tumoren
Type of study:Phase N/A
Contact: Prof. Dr. Stefan Rieken (Kontaktperson)
[stefan.rieken@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Klaus Herfarth (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

AIO-YMO/TRK-0415/ FORCE

Title:Fostering Efficacy of Anti - PD-1 - Treatment: Nivolumab Plus Radiotherapy in Advanced NSCLC
Indication:Fortgeschrittenes nicht-kleinzelliges Lungenkarzinom
Type of study:Phase II
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Dr.med. Farastuk Bozorgmehr (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03044626
EudraCT: 2015-005741-31 (siehe EU klinisches Studienregister)

Blueprint / BLU-667-1101

Title:A Phase 1 Study of the Highly-selective RET Inhibitor, BLU-667, in Patients with Thyroid Cancer, Non-Small Cell Lung Cancer (NSCLC) and Other Advanced Solid Tumors
Indication:Carcinoma, Non-Small-Cell LungLung Neoplasms
Type of study:Phase I
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Michael Thomas (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03037385
EudraCT: 2016-004390-41 (siehe EU klinisches Studienregister)

CANOPY-1 / CACZ885U230[Rekrutierung nach Anfrage]

Title:A randomized, double-blind, placebo-controlled, phase III study evaluating the efficacy and safety of pembrolizumab plus platinum-based doublet chemotherapy with or without canakinumab as first line therapy for locally advanced or metastatic non-squamous and squamous non-small cell lung cancer subjects (CANOPY-1)
Indication:Lokal fortgeschrittener oder metastasierter nicht-kleinzelliger Lungenkrebs (NSCLC)
Type of study:Phase III
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Michael Thomas (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03631199
EudraCT: 2018-001547-32 (siehe EU klinisches Studienregister)

CRISP / AIO-TRK-0315

Title:Clinical Research Platform Into Molecular Testing, Treatment and Outcome of Non-Small Cell Lung Carcinoma Patients
Indication:Carcinoma, Non-Small-Cell LungLung Neoplasms
Type of study:Phase
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Dr. med. Helge Bischoff (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02622581
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Canakinumab

Title:A Phase III, Multicenter, Randomized, Double Blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Canakinumab Versus Placebo as Adjuvant Therapy in Adult Subjects With Stages AJCC/UICC v. 8 II -IIIA and IIIB (T>5cm N2) Completely Resected (R0) Non-small Cell Lung Cancer (NSCLC)
Indication:Lung NeoplasmsCarcinoma, Non-Small-Cell Lung
Type of study:Phase III
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Michael Thomas (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03447769
EudraCT: 2017-004011-39 (siehe EU klinisches Studienregister)

DURATION / AIO-YMO/TRK-0416

Title:Durvalumab (MEDI4736) in Frail and Elder Patients With Metastatic NSCLC (DURATION)
Indication:CarcinomaLung NeoplasmsCarcinoma, Non-Small-Cell LungAdenocarcinoma
Type of study:Phase II
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03345810
EudraCT: 2016-003963-20 (siehe EU klinisches Studienregister)

GSK ICOS

Title:A Phase II, Randomized, Open-label Platform Trial Utilizing a Master Protocol to Study Novel Regimens Versus Standard of Care Treatment in NSCLC Participants
Indication:Nicht-kleinzelliges Lungenkarzinom
Type of study:Phase II
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Michael Thomas (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03739710
EudraCT: 2018-001316-29 (siehe EU klinisches Studienregister)

HeiMeKom

Title:Heidelberger Meilenstein-Kommunikationskonzept (HeiMeKOM) - Eine Mixed-Method Studie
Indication:Nasennebenhöhlenkrebs, Mittelohrkrebs, Luftröhrenkrebs, Thymuskrebs, Kehlkopfkrebs, Lungenkrebs
Type of study:Phase N/A
Contact: Anja Siegle (Kontaktperson)
[Anja.Siegle@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Michael Thomas (Leiter klinische Prüfung)
Trial Register: Die Studie ist beim "DRKS - Deutsches Register Klinischer Studien" registriert. Siehe DRKS00013469
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

MERU / M16-298

Title:A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First-Line Platinum-Based Chemotherapy in Subjects With Extensive Stage Small Cell Lung Cancer (MERU)
Indication:Lung Neoplasms Small Cell Lung Carcinoma
Type of study:Phase III
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Dr. med. Helge Bischoff (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03033511
EudraCT: 2016-003503-64 (siehe EU klinisches Studienregister)

MSD Pembro | MK-3475-799

Title:A Phase 2 Trial of Pembrolizumab (MK-3475) in Combination with Platinum Doublet Chemotherapy and Radiotherapy for Participants with Unresectable, Locally Advanced Stage III Non-Small Cell Lung Cancer (NSCLC) (KEYNOTE-799)
Indication:Therapie nichtkleinzelliger Lungenkarzinome (NSCLC)
Type of study:Phase III
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Dr. med. Helge Bischoff (Prüfer)
Trial Register: No trial registry number given.
EudraCT: 2018-000714-37 (siehe EU klinisches Studienregister)

NEOMUN

Title:Neoadjuvant Anti PD-1 Immunotherapy in Resectable Non-small Cell Lung Cancer [NEOMUN]
Indication:Lung NeoplasmsCarcinoma, Non-Small-Cell Lung
Type of study:Phase II
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03197467
EudraCT: 2017-000105-20 (siehe EU klinisches Studienregister)

OPTIMISE-1

Title:Oncologic Therapy Support Via Means of a Dedicated Mobile App - a Prospective Feasibility Evaluation
Indication:Strahlentherapie mit potenziell kurativer Absicht eines primär thorakalen oder Beckenziels.
Type of study:Phase N/A
Contact: Dr. med. Rami El-Shafie (Kontaktperson)
[Rami.Elshafie@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03168048
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

PROMISE

Title:Prädiktive immunologische Signaturen bei Lungenkrebs
Indication:Nicht-kleinzelliges Lungenkarzinom
Type of study:Phase N/A
Contact: Jennifer Rehberger (Study Nurse)
[Jennifer.Rehberger@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Dirk Jäger (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Pembro Ipi Firstline / MK-3475-598

Title:A Phase 3, Randomized, Double-Blind Study of Pembrolizumab Plus Ipilimumab vs Pembrolizumab Plus Placebo in Previously Untreated, Stage IV, Metastatic Non-small Cell Lung Cancer Subjects Whose Tumors Are PD-L1 Positive (TPS = 50%) (KEYNOTE-598)
Indication:Carcinoma, Non-Small-Cell Lung
Type of study:Phase III
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Dr. med. Helge Bischoff (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03302234
EudraCT: 2016-004364-20 (siehe EU klinisches Studienregister)

Roche ALINA / BO40336

Title:A Phase III, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With Completely Resected Stage IB (Tumors Equal to or Larger Than 4cm) to Stage IIIA Anaplastic Lymphoma Kinase Positive Non-Small Cell Lung Cancer
Indication:Carcinoma, Non-Small-Cell LungLung Neoplasms
Type of study:Phase III
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Dr. med. Helge Bischoff (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03456076
EudraCT: 2017-004331-37 (siehe EU klinisches Studienregister)

Roche B-FAST / BO29554

Title:A Phase II/III Multicenter Study Evaluating the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) Harboring Actionable Somatic Mutations Detected in Blood (B-FAST: Blood-First Assay Screening Trial)
Indication:Lung NeoplasmsCarcinoma, Non-Small-Cell Lung
Type of study:Phase II/III
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Dr. med. Helge Bischoff (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03178552
EudraCT: 2017-000076-28 (siehe EU klinisches Studienregister)

VISION / MS200095-0022

Title:A Phase II, Single-arm Trial to Investigate Tepotinib in Advanced (Stage IIIB/IV) Non-small Cell Lung Cancer With MET Exon 14 (METex14) Skipping Alterations (VISION)
Indication:Lung NeoplasmsCarcinoma, Non-Small-Cell Lung
Type of study:Phase II
Contact: Petra Kettenring (Kontaktperson)
[Thoraxklinik.Studienkoordination-Onkologie@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Michael Thomas (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02864992
EudraCT: 2015-005696-24 (siehe EU klinisches Studienregister)

Vaccibody (VBN-01) / [Rekrutierung nach Rücksprache]

Title:An open labelled first human dose phase 1/2a study to evaluate safety, feasibility and efficacy of multiple dosing with individualised VB10.NEO immunotherapy in patients with locally advanced or metastatic melanoma, NSCLC, clear renal cell carcinoma, urothelial cancer or squamous cell carcinoma of head and neck, who did not reach complete responses with current standard of care immune checkpoint blockade
Indication:Plattenepithelkarzinomen, Melanom, Kopf-/Hals Tumore, Nicht-kleinzelliger Lungenkrebs, Nierenzellkarzinom
Type of study:Phase I
Contact: Annette Köster (Study Nurse)
[Annette.Koester@med.uni-heidelberg.de]
Investigator: Prof. Dr. Jürgen Krauss (Leiter klinische Prüfung)
Trial Register: No trial registry number given.
EudraCT: 2017-002474-39 (siehe EU klinisches Studienregister)