Comprehensive analysis of every cancer patient at every major decision milestone
NCT MASTER Program
The center-wide NCT MASTER (Molecularly Aided Stratification for Tumor Eradication) Program is part of the activities of the NCT Precision Oncology Program (NCT POP) and has been created to provide a platform for comprehensive, multidimensional characterization of all cancer patients seen at NCT Heidelberg and Heidelberg University Hospital.
The ultimate goal of this multidisciplinary effort is to enable clinically meaningful precision cancer medicine by applying current and future technologies that capture the molecular, cellular, and functional properties of individual human tumors in an integrated fashion. To this end, the DKFZ-Heidelberg Center for Personalized Oncology (DKFZ-HIPO), the DKFZ Genomics and Proteomics Core Facility, the Division of Applied Bioinformatics and other bioinformatics groups on campus, and NCT POP work jointly on strategies for rapid-turnaround molecular profiling and streamlined data acquisition and analysis in a clinical setting.
As of February 2017, more than 550 younger patients with advanced-stage malignancies and patients with rare tumors have been enrolled. Evaluation of the data by a dedicated Molecular Tumor Board has allowed categorization of patients into seven different intervention baskets and formulation of evidence-based recommendations for clinical management in more than 70% of cases.
To substantially increase the proportion of patients who are eligible for individualized precision oncology approaches and leverage the widespread expertise in biology-driven stratification of adult cancer patients across Germany, we have been collaborating since February 2016 with all Partner Sites of the German Cancer Consortium (DKTK; Berlin, Dresden, Essen/Düsseldorf, Frankfurt/Mainz, Freiburg, Munich, Tübingen) on a common path for clinical exome and RNA sequencing, including a joint DKTK Molecular Tumor Board in which we determine therapeutic choices for individual patients on a weekly basis.
» More information on how to participate in NCT MASTER.