NCT Research

NCT Clinical Cancer Program - Sarcoma


The NCT Sarcoma Program has a leading position in Germany. The Division of Orthopedic Oncology functions as surgical reference center of the international osteosarcoma and Ewing sarcoma study groups. Radiooncology provides unique treatment modalities. Clinical research includes IITs (Schmitt BMC Cancer 2011) and has enabled development of novel PET methodologies (Dimittrakopoulou-Strauss J Nucl Med 2010), intraoperative radiotherapy, bone surgery, and hemipelvic reconstructions (Lehner Arch Orth Trau Surg 2010; Witte Eur J Surg Oncol 2009). Translational research establishes integrative molecular analysis of soft-tissue sarcomas (Renner Genes Chromosomes Cancer 2012; Fellenberg Int J Cancer 2010) including NGS technology (Sarcoma Competence Network and HIPO/POP).


  1. Renner M, Czwan E, Hartmann W, Penzel R, Brors B, Eils R, Wardelmann E, Büttner R, Lichter P, Schirmacher P, Mechtersheimer G. MicroRNA profiling of primary high-grade soft tissue sarcomas. Genes Chromosomes Cancer. 2012 Nov;51(11):982-96.
  2. Boeuf S, Bovée JV, Lehner B, van den Akker B, van Ruler M, Cleton-Jansen AM, Richter W. BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors. BMC Cancer. 2012 Oct 22;12:488.
  3. Roeder F, Schulz-Ertner D, Nikoghosyan AV, Huber PE, Edler L, Habl G, Krempien R, Oertel S, Saleh-Ebrahimi L, Hensley FW, Buechler MW, Debus J, Koch M, Weitz J, Bischof M. A clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma. BMC Cancer. 2012 Jul 12;12:287.
  4. Schmitt T, Lehner B, Kasper B, Bischof M, Roeder F, Dietrich S, Dimitrakopoulou-Strauss A, Strauss LG, Mechtersheimer G, Wuchter P, Ho AD, Egerer G. A phase II study evaluating neo-/adjuvant EIA chemotherapy, surgical resection and radiotherapy in high-risk soft tissue sarcoma. BMC Cancer. 2011 Dec 7;11:510.
  5. Dimitrakopoulou-Strauss A, Strauss LG, Egerer G, Vasamiliette J, Mechtersheimer G, Schmitt T, Lehner B, Haberkorn U, Stroebel P, Kasper B. Impact of dynamic 18F-FDG PET on the early prediction of therapy outcome in patients with high-risk soft-tissue sarcomas after neoadjuvant chemotherapy: a feasibility study. J Nucl Med. 2010 Apr;51(4):551-8.