NCT Research

NCT Clinical Cancer Program in Colorectal Cancer

Expertise

The program offers comprehensive multidisciplinary treatment concepts and innovative clinical trials (e.g., SYNCHRONOUS, Rahbari BMC Cancer 2012), PANDORA (Combs BMC Cancer 2012), MICORYX (von Knebel-Doeberitz Fam Cancer 2013), and MARACON). Strong epidemiological cohorts (DACHS, BLITZ, ColoCare) support NCT research projects (e.g., Miller Lancet 2013, Brenner J Clin Oncol 2012, and JAMA 2010). A DFG-funded clinical research unit (KFO 227) aims to delineate key mechanisms of CRC metastasis (e.g., Dieter Cell Stem Cell 2011; Kloor J Clin Oncol 2011 and Lancet Oncol 2012; Rahbari J Clin Oncol 2012).

Colorectal Cancer
 

Scientific Goals

  • Molecular basis of CRC growth, invasion, metastases and resistance (e.g., KFO 227)
  • Systematic characterization of tumor–host immune interactions.
  • Understand functional and genetic heterogeneity of tumor initiating cells and develop therapeutic targets using RNAi and small substance library screens.
  • Developing novel approaches for therapy and prevention of microsatellite-unstable CRC.
  • Identify molecular markers for prevention and early detection.
  • Translation of novel predictive and prognostic markers into diagnostic assays.

  1. Brenner H, Tao S, Haug U. Low-Dose aspirin use and performance of immunochemical occult blood tests. JAMA 2010; 204(22):2513-20. (IF 29,98)
  2. Dieter SM*, Ball CR*, Hoffmann CM*, Nowrouzi A, Herbst F, Zavidij O, Abel U, Arens A, Weichert W, Brand K, Koch M, Weitz J, Schmidt M, von Kalle C, Glimm H. Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell 2011; 9(4):357-65 (IF 27,36)
  3. Kloor M, Voigt AY, Schackert HK, Schirmacher P, von Knebel Doeberitz M, Bläker H. Analysis of EPCAM protein expression in diagnostics of Lynch syndrome. J Clin Oncol 2011; 29(2):223-227 (IF 18,04)
  4. Rahbari NN, Bork U, Motschall E, Thorlund K, Büchler MW, Koch M, Weitz J. Molecular detection of tumor cells in regional lymph nodes is associated with disease recurrence and poor survival in node-negative colorectal cancer: a systematic review and meta-analysis. J Clin Oncol 2012; 30(1):60-70 (IF 18,04)
  5. Kloor M, Huth C, Voigt AY, Benner A, Schirmacher P, von Knebel Doeberitz M, Bläker H. Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study. Lancet Oncol 2012;13(6):598-606 (IF 21,86)
  6. Brenner H, Chang-Claude J, Rickert A ,Seiler CM, Hoffmeister M. Risk of colorectal cancer after detection and removal of adenomas at colonoscopy: population-based case-control study. J Clin Oncol 2012; 30(24):2969-76 (IF 18,04)