Contact

 

Prof. Dr. med. Stefan M. Pfister
Phone: +49 6221 424681

E-mail: s.pfister@dkfz.de

 

 

Impact in cancer research...

 

is achieved once the patient benefits.

Pediatric Neurooncology

DKFZ
 
 
 

Our group/department has:

  • Identification of distinct and clinically meaningful biological subgroups of medulloblastoma (MB) and ependymoma (EP)(Mendrzyk et al., 2006 Clin Cancer Res; Pfister et al., 2009 J Clin Oncol; Korshunov et al., 2010a J Clin Oncol; Korshunov et al., 2010b J Clin Oncol; Remke et al., 2011 J Clin Oncol; Remke et al., 2011 Journal of Clinical Oncology; Witt et al., 2011 Cancer Cell).
  • Discovery of the association between chromothripsis and germline (or early somatic) mutations in medulloblastoma (Rausch et al., 2012 Cell).
  • Identification of new potentially druggable hits (e.g., tratraploidy) and predictive biomarkers in response to SMO inhibitors in medulloblastoma  (Jones et al., 2012a Nature; Kool et al., 2013 submitted)
  • Molecular definition of embryonal tumors with abundant neuropil and true rosettes (ETANTR), a highly aggressive and universally fatal embryonal brain tumor in infants (Pfister et al., 2009 Acta Neuropathol; Korshunov et al., 2010 Acta Neuropathol). 
  • Identification of BRAF fusion (and other less frequent hits in the MAPK pathway) as the hallmark driver event in pilocytic astrocytoma and generation of the first mouse model for this disease (Pfister et al., 2008 J Clin Invest; Cin et al., 2011 Acta Neuropathol; Gronych et al., 2011 J Clin Invest; Jones et al., 2013 Nature Genetics).
  • Description of the first histone mutation in cancer, namely in childhood glioblastoma (Schwartzentruber et al., 2012 Nature).
  • Molecular classification of glioblastoma multiforme across all age groups (Sturm et al., 2012 Cancer Cell, Bender et al., 2013 Cancer Cell).

2010 – 2013

  • Bender, S., Tang, Y., Lindroth, A.M., Hovestadt, V., Jones, D.T.W., Kool, M., Zapatka, M., Nothcott, P.A., Sturm, D., Wang, W., Radlwimmer, B., Højfeldt, J.W., Truffaux, N., Castel, D., Schubert, S., Ryzhova, M., Seker-Cin, H., Gronych, J., Johann, P.D., Stark, S., Meyer, J., Milde, T., Schuhmann, M., Ebinger, M., Monoranu, C.-M., Ponnuswami, A., Chen, S., Jones, C., Witt, O., Collins, V.P., von Deimling, A., Jabado, N., Puget, S., Grill, J., Helin, K., Korshunov, A., Lichter, P., Monje, M., Plass, C., Cho, Y.-J., Pfister, S.M. (2013) Reduces H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M-mutant pediatric high-grade gliomas. Cancer Cell. 2013 Nov 11;24(5):660-72.
  • Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P; International Cancer Genome Consortium PedBrain Tumor Project, Pfister SM. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet. 2013 Aug;45(8):927-32.
  • Sturm D, Witt H, Hovestadt V, Quang D-AK, Jones DT, Konermann C, Pfaff E, Sill M, Bender S, Kool M, Becker N, Zucknick M, Hielscher T, Xiao-Yang L, Fontebasso AM, Ryzhova M, Tönjes M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald MC, Hauch H, Pekrun A, Radlwimmer B, Niehues T, von Komorowski G, Dürken M, Kulozik AE, Madden J, Donson A, Foreman NK, Drissi R, Fouladi M, Scheurlen W, von Deimling A, Monuranu C, Roggendorf W, Herold-Mende C, Unterberg A, Kramm CM, Felsberg J, Hartmann C, Milde T, Witt O, Lindroth AM, Schwartzentruber J, Faury D, Fleming A, Zakrzewska M, Liberski PP, Zakrzewski K, Zapatka M, Hauser P, Garami M, Klekner A, Bognar L, Morissy S, Cavalli F, Taylor MD, Wiestler B, Wick W, van Sluis P, Koster J, Versteeg R, Volkmann R, Mikkelsen T, Aldape K, Reifenberger G, Collins VP, Majewksi J, Korshunov A, Lichter P, Plass C*, Jabado N*, Pfister SM*. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell. 2012 Oct 16;22(4):425-37
  • Jones DT*, Jäger N*, Kool M, Zichner T, Hutter B, Sultan M, Cho YJ, Pugh TJ, Hovestadt V, Stütz AM, Rausch T, Warnatz HJ, Ryzhova M, Bender S, Sturm D, Pleier S, Cin H, Pfaff E, Sieber L, Wittmann A, Remke M, Witt H, Hutter S, Tzaridis T, Weischenfeldt J, Raeder B, Avci M, Amstislavskiy V, Zapatka M, Weber UD, Wang Q, Lasitschka B, Bartholomae CC, Schmidt M, von Kalle C, Ast V, Lawerenz C, Eils J, Kabbe R, Benes V, van Sluis P, Koster J, Volckmann R, Shih D, Betts MJ, RussellRB, Coco S, Paolo Tonini G, Schüller U, Hans V, Graf N, Kim YJ, Monoranu C, Roggendorf W, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, von Deimling A,Witt O, Maass E, Rössler J, Ebinger M, Schuhmann MU, Frühwald MC, Hasselblatt M, Jabado N, Rutkowski S, von Bueren AO, Williamson D, Clifford SC, McCabe MG, PeterCollins V, Wolf S, Wiemann S, Lehrach H, Brors B, Scheurlen W, Felsberg J, Reifenberger G, Northcott PA, Taylor MD, Meyerson M, Pomeroy SL, Yaspo ML, Korbel JO, Korshunov A, Eils R*, Pfister SM*, Lichter P*. Dissecting the genomic complexity underlying medulloblastoma. Nature. 2012 Jul 25.
  • Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tönjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jäger N, Rausch T, Ryzhova M, Korbel JO, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann MU, Scheurlen W, Pekrun A, Frühwald MC, Roggendorf W, Kramm C, Dürken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel P, Kulozik AE, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins VP, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J*, Pfister SM*, Jabado N*. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012 Jan 29;482(7384):226-31.
  • 2013 Kool, M: Society for Pediatric Oncology (SIOP) Basic Science Award
  • 2013 Kool, M: Society for Neurooncology (SNO) Pediatric Translational Research Award

  • 2013 Pfister, S: German Cancer Award, Translational Part
  • 2013 Pfister, S: Cancer Award of Württemberg
  • 2013 Sturm S: Selma-Meyer-Dissertation Award of the German Society for Pediatric and Adolescent Medicine
  • 2013 Sturm, S: Dissertation Award of the German Society for Hematology and Oncology (DGHO)
  • 2013 Sturm, D: Walther and Christine Richtzenhain Award
  • 2013 Jones, D: Waltraud Lewenz Award
  • 2011 Remke, M: Walther and Christine RichtzenhainAward
  • 2011 Remke, M: Lina Marguerite Siebert Award
  • 2011 Pfister, S: Fritz-Lampert Award for Pediatric Hematology and Oncology (together with Prof. Dr. Andrey Korshunov (G380)
  • 2011 Pfister, S: Alfred-Müller Award for Neurooncology
  • 2011 Witt, H: AACR-GlaxoSmithKline Clinical Cancer Research Scholar Award
  • 2010 Remke, M: Selma-Meyer-Dissertation Award of the German Society for Pediatric and Adolescent Medicine
  • 2010 Remke, M: DesitinYoung Investigator Award of the German Society of Pediatric Neurology