Dr. Jörg D. Hoheisel
Phone: +49 6221 424680




Functional Genome Analysis


Our group/department has:

  • performed epigenetic and functional analyses of miRNAs in breast, pancreatic and ovarian cancer (Cancer Res 2010, 70:9175-9184; Breast Canc Res Treat 2012, 135:705-713; EMBO Mol Med 2013 5:413-429; Breast Cancer Res 2013, 15:R109. Oncogene 2014, in press, doi: 10.1038/onc.2013.515).

  • performed molecular diagnosis and development of therapeutic options for pancreatic cancer (Nature Meth 2011, 8:841-843; PLoS ONE, 2013 8:e60870; J Cell Sci 2013, 126:3380-3389).

  • performed quantitative measurements on protein expression and conformation variation (J Proteomics 2012 75:3747-3759; J Biol Chem 2013, 288:32517-32527; Proteomics Clin Appl 2013, 7:802-812).

  • made technical developments in proteome analysis (Mol Cell Prot 2010, 9:1271-80; J Proteome Res 2011, 10:1316-1322; Proteomics Clin Appl 2013, 7, 8-16).

  • developed single-molecule sensitive assay systems (J Prot Res 2011, 10:1316-22; J Proteome Res 2011, 10:1316-1322).

2010 – 2013

  • Schröder C, Jacob A, Tonack S, Radon T, Sill M, Zucknick M, Rüffer S, Costello E, Neoptolemos J, Crnogorac-Jurcevic T, Bauer A, Fellenberg K, Hoheisel JD. Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-specific antibodies Mol Cell Prot 2010; 9, 1271-1280

  • de Souza Rocha Simonini P, Breiling A, Gupta N, Malekpour M, Youns M, Omranipour R, Malekpour F, Volinia S, Croce CM, Najmabadi H, Diederichs S, Sahin Ö, Mayer D, Lyko F, Hoheisel JD, Riazalhosseini Y. Epigenetically de-regulated microRNA-375 activates Estrogen Receptor alpha activity in breast cancer Cancer Res 2010; 70, 9175-9184

  • Keller A, Leidinger P, Bauer A, ElSharawi A, Haas J, Backes C, Wendschlag A, Giese N, Tjaden C, Ott K, Werner J, Hackert T, Ruprecht K, Huwer H, Huebers J, Jacobs G, Rosenstiel P, Dommisch H, Schäfer A, Müller-Quernheim J, Wullich B, Keck B, Graf N, Reichrath J, Vogel B, Nebel A, Jager SU, Staehler P, Amarantos I, Boisguerin V, Staehler C, Beier M, Scheffler M, Büchler MW, Wischhusen J, Häusler SFM, Dietl J, Hofmann S, Lenhof HP, Schreiber S, Katus HA, Rottbauer W, Meder B, Hoheisel JD, Franke A, Meese E. Towards discovering the blood-born miRNome of human diseases Nature Meth 2011; 8, 841-843

  • Botla SK, Gholami AM, Malekpour M, Moskalev EA, Fallah M, Jandaghi P, Aghajani A, Bondar IS, Omranipour R, Malekpour F, Mohajeri A, Babadi AJ, Sahin Ö, Bubnov VV, Najmabadi H, Hoheisel JD, Riazalhosseini Y. Diagnostic values of GHSR DNA methylation pattern in breast cancer Breast Canc Res Treat 2012; 135, 705-713

  • Wolf J, Müller-Decker K, Flechtenmacher C, Zhang F, Shahmoradgoli M, Mills GB, Hoheisel JD, Böttcher M. SALL1 acts as tumor suppressor and regulator of CDH1 Oncogene 2014; in press, doi: 10.1038/onc.2013.515

  • Work at the division is funded by the European Union, the German Federal Ministry of Education and Science (BMBF), the Deutsche Krebshilfe (German Cancer Aid) and the State of Baden-Württemberg.