Contact

 

Prof. Dr. Andreas von Deimling

E-mail: andreas.vondeimling@med.uni-heidelberg.de

 

 

Clinical Cooperation Unit Neuropathology

 

Our group/department has:

  • Developed a mutation specific antibody to IDH1R132H nowadays used in every routine neuropathology (Capper et al. Acta Neuropathologica 2009).
  • Developed a mutation specific antibody to BRAFV600E (Capper et al. Acta Neuropathologica 2011).
  • Established VE1 antibody as a useful tool for the diagnosis of BRAF mutations in multiple tumor entities (Koelsche et al. Brain Pathology 1214; Sahm et al. Blood 2013; Capper et al. Acta Neuropathologica 2012; and many more)
  • Developed a diagnostic test for SFT/hemangiopericytoma based on detection of NAB2.STAT6 fusion protein translocated to the nucleus (Schweizer et al. Acta Neuropathologica 2013).
  • Determined KLF4 and TRAF7 mutations as the essential mutations in secretory meningioma (Reuss et al. Acta Neuropathologica 2013).

2010 – 2013

  • Neurofibromin specific antibody differentiates malignant peripheral nerve sheath tumors (MPNST) from other spindle cell neoplasms.
    Reuss DE, Habel A, Hagenlocher C, Mucha J, Ackermann U, Tessmer C, Meyer J, Capper D, Moldenhauer G, Mautner V, Frappart PO, Schittenhelm J, Hartmann C, Hagel C, Katenkamp K, Petersen I, Mechtersheimer G, von Deimling A. Acta Neuropathologica. 2014
  • Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Korshunov A, Sturm D, Ryzhova M, Hovestadt V, Gessi M, Jones DT, Remke M, Northcott P, Perry A, Picard D, Rosenblum M, Antonelli M, Aronica E, Schuller U, Hasselblatt M, Woehrer A, Zheludkova O, Kumirova E, Puget S, Taylor MD, Giangaspero F, Peter Collins V, von Deimling A, Lichter P, Huang A, Pietsch T, Pfister SM, Kool M.
    Acta Neuropathologica. 2014
  • Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein.
    Schweizer L, Koelsche C, Sahm F, Piro R, Capper D, Reuss D, Pusch S, Habel A, Meyer J, Göck T, Jones D, Mawrin C, Schittenhelm J, Becker A, Heim S, Simon M, Herold-Mende C, Mechtersheimer G, Paulus W, König R, Wiestler O, Pfister S, von Deimling A. Acta Neuropathologica. 2013 125(5):651-658
  • AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry.
    Sahm F, Bissel J, Koelsche C, Schweizer L, Capper D, Reuss D, Bohmer K, Lass U, Gock T, Kalis K, Meyer J, Habel A, Brehmer S, Mittelbronn M, Jones DT, Schittenhelm J, Urbschat S, Ketter R, Heim S, Mawrin C, Hainfellner JA, Berghoff AS, Preusser M, Becker A, Herold-Mende C, Unterberg A, Hartmann C, Kickingereder P, Collins VP, Pfister SM, von Deimling A. Acta Neuropathologica. 2013 126(5):757-762
  • Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation specific monoclonal antibody.
    Capper D, Preusser M, Habel A, Sahm F, Ackermann U, Schindler G, Pusch S, Mechtersheimer G, Zentgraf H, von Deimling A.
    Acta Neuropathologica. 2011 122(1):11-19