We have applied genomics and epigenomics technologies to identify molecular signatures for cancer subclassification and genes associated with tumorigenic processes. In collaboration with clinical partners, we generated multiple different (orthogonal) data sets on the same tumor samples. Our own contributions to these projects consisted primarily in providing our expertise in microarray and data analysis for mRNA and miRNA expression.
The group has:
- played a leading role in the ICGC project describing for the first time the age-dependence of the TMPRSS2:ERG rearrangement in prostate cancer (Weischenfeldt et al., Cancer Cell 2013)
- been the first to show the association of circulating miRNAs with prostate cancer progression (Brase et al., Int J Cancer 2011)
- found that lung cancer can be identified by analyzing gene expression in cells derived from endobronchial lining fluid (Kahn et al., J Thorac Oncol 2012)
- discovered that circulating miRNAs are associated with non-small cell lung cancer (NSCLC) prognosis (Kaduthanam et al., Lung Cancer 2013).
Most of our work has been facilitated by the attainment of substantial funding for large interdisciplinary research consortia, i.e. IG-Prostate Cancer (BMBF) and Systems Biology of Prostate Cancer (Austrian National Foundation). In 2010, we have successfully attracted funding for the realization of the German ICGC project “The Genomes of Early Onset Prostate Cancers” (BMBF). Holger Sültmann has been the coordinator of all these consortia.