Contact

 

Prof. Dr. Holger Sültmann
Phone: +49 6221 565934

E-mail: h.sueltmann@dkfz.de

 

 

Genome research for...

 

the molecular classification and diagnosis of cancer.

Cancer Genome Research

DKFZ
 
 
 

Our group/department has:

We have applied genomics and epigenomics technologies to identify molecular signatures for cancer subclassification and genes associated with tumorigenic processes. In collaboration with clinical partners, we generated multiple different (orthogonal) data sets on the same tumor samples. Our own contributions to these projects consisted primarily in providing our expertise in microarray and data analysis for mRNA and miRNA expression. 

The group has:

  • played a leading role in the ICGC project describing for the first time the age-dependence of the TMPRSS2:ERG rearrangement in prostate cancer (Weischenfeldt et al., Cancer Cell 2013)

  • been the first to show the association of circulating miRNAs with prostate cancer progression (Brase et al., Int J Cancer 2011)

  • found that lung cancer can be identified by analyzing gene expression in cells derived from endobronchial lining fluid (Kahn et al., J Thorac Oncol 2012)

  • discovered that circulating miRNAs are associated with non-small cell lung cancer (NSCLC) prognosis (Kaduthanam et al., Lung Cancer 2013).

Most of our work has been facilitated by the attainment of substantial funding for large interdisciplinary research consortia, i.e. IG-Prostate Cancer (BMBF) and Systems Biology of Prostate Cancer (Austrian National Foundation). In 2010, we have successfully attracted funding for the realization of the German ICGC project “The Genomes of Early Onset Prostate Cancers” (BMBF). Holger Sültmann has been the coordinator of all these consortia.

2010 – 2013

  • Weischenfeldt J*, Simon R*, Feuerbach L*, Schlangen K*, Weichenhan D*, Minner S*, Wuttig D*, Warnatz HJ, Stehr H, Rausch T, Jaeger N, Gu L, Bogatyrova O, Stuetz AM, Claus R, Eils J, Eils R, Gerhaeuser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Fälth M, Gade S, Schmidt M, Amschler N, Hass T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sültmann H*, Sauter G*, Plass C*, Brors B*, Yaspo ML*, Korbel JO*, Schlomm T* (* shared first / senior authorship): Integrative genomic analyses reveal androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell 2013; 23(2), 159-170

  • Kaduthanam S, Gade S, Meister M, Brase JC, Johannes M, Dienemann H, Warth A, Schnabel PA, Herth FJ, Sültmann H, Muley T, Kuner R. Serum miR-142-3p is associated with early relapse in operable lung adenocarcinoma patients. Lung Cancer 2013; 80(2), 223-227

  • Brase JC, Johannes M, Schlomm T, Fälth M, Haese A, Steuber T, Beißbarth T, Kuner R, Sültmann H: Circulating micro RNAs are correlated with tumor progression in prostate cancer. International Journal of Cancer 2011; 128 (3), 608-616

  • Kahn N, Meister M, Eberhardt R, Muley T, Schnabel PA, Bender C, Johannes M, Keitel D, Sültmann H, Herth FJF, Kuner R: Early Detection of Lung Cancer by Molecular Markers in Endobronchial Epithelial-Lining Fluid. Journal of Thoracic Oncology 2012; 7(6), 1001-1008

  • Brase JC, Johannes, M, Mannsperger, H, Fälth, M, Metzger, J, Kacprzyk, LA, Andrasiuk T, Gade S, Meister M, Sauter, G, Simon R, Schlomm T, Beißbarth T, Korf U, Kuner R, Sültmann H: TMPRSS2-ERG specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-beta signaling. BMC Cancer 2011; 11(1):507

  • BMBF Program for Medical Genome Research – International Cancer Genome Consortium: The Genomes of Early Onset Prostate Cancers (2010-2015)

  • BMBF Program for Medical Genome Research – Medical Systems Biology (2009-2012) and e:Bio (2013-2015)

  • BMBF, NGFN – Prostate Cancer Genome Research Network: Translating Molecular Profiles into Enhanced Diagnosis of Clinically Significant Prostate Cancer (2008-2011) and MUTANOM (2009-2012)

  • Deutsche Krebshilfe, Circulating miRNA in prostate cancer diagnosis (2012-2014)

  • Austrian National Foundation, Systems Biology of Prostate Cancer (2006-2011)

  •  Award of the European Society of Human Genetics to Peter Lichter (2012)