Contact

 

Prof. Dr. Mark E. Ladd
Phone: +49 6221 422550

E-mail: mark.ladd@dkfz.de

 

 

We develope...

 

cutting-edge imaging methods for the diagnosis and treatment of cancer.

Medical Physics in Radiology

DKFZ
 
 
 

Our group/department has:

  • Non-invasively measured the in vivo potassium and chloride concentration for the first time world-wide using 7 Tesla MRI (Umathum R et al. Radiology 2013 and Nagel A et al. Radiology 2014)
  • Expanded the theoretical modelling of Chemical Exchange Saturation Transfer (CEST) imaging and provided the first direct in vitro observation of protein folding using this technique (Zaiss M et al. NMR Biomed 2014 and Zaiss M et al. NMR Biomed 2013)
  • Provided the theoretical foundation for and experimental verification of direct imaging of pore shape with magnetic resonance diffusion imaging (Kuder TA et al. Phys Rev Lett 2013)
  • Developed novel X-ray methodology allowing the acquisition of 3D, time-resolved images for interventional guidance without increasing radiation dose versus conventional 2D methods (Flach B et al. Med Phys 2013)
  • Designed and implemented the first plenoptic optical camera to be used in diagnostic imaging and used this system to create the world’s first MRI-compatible, non-contact optical imager for multimodality imaging (Cao L et al. Opt Express 2011)
  • Developed a modular contrast agent that enables use with multiple imaging technologies (e.g. PET and MRI) and extension to molecular patient-specific therapies (Braun K et al. Int J Med Sci 2014)

2010 – 2013

  • Umathum R, Rösler MB, Nagel AM (2013). In vivo 39K MR imaging of human muscle and brain. Radiology 269(2):569-76. doi: 10.1148/radiol.13130757.
  • Zaiss M, Bachert P (2013). Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods. Phys Med Biol 58(22):R221-69.
  • Kuder TA, Bachert P, Windschuh J, Laun FB (2013). Diffusion pore imaging by hyperpolarized xenon-129 nuclear magnetic resonance. Phys Rev Lett 111(2):028101.
  • Flach B, Kuntz J, Brehm M, Kueres R, Bartling S, Kachelrieß M (2013). Low dose tomographic fluoroscopy: 4D intervention guidance with running prior. Med Phys 40(10):101909. doi: 10.1118/1.4819826.
  • Mühlhausen U, Komljenovic D, Bretschi M, Leotta K, Eisenhut M, Semmler W, Bäuerle T (2011). A novel PET tracer for the imaging of αvβ3 and αvβ5 integrins in experimental breast cancer bone metastases. Contrast Media Mol Imaging 6(6):413-20. doi: 10.1002/cmmi.435.