PD Mag. Dr. Dr. K. Podar
Phone: +49 6221 5638689


Signal transduction and the tumor microenvironment


Our group/department has:

  • demonstrated that high constitutive hypoxia-inducible factor-1alpha (Hif-1alpha) expression in MM cells is associated with oncogenic c-Myc; anti-MM agents that decrease Hif-1alpha and c-Myc levels include bortezomib, lenalidomide, enzastaurin and adaphostin; a c-Myc/Hif-1alpha-dependent pathway mediates vascular endothelial growth factor production and secretion; and there exists a significant link between HIF1A overexpression and poor prognosis. These findings demonstrate the potential therapeutic benefit of targeting angiogenesis via a c-Myc/Hif-1alpha-dependent pathway in MM (Cancer Res 2009, 69:5082-90).
  • demonstrated a novel role for beta-catenin in ER stress and apoptotic signaling (Blood 2009, 113:1513-21).
  • demonstrated a pivotal role for Mcl-1 in bortezomib-induced apoptosis (Oncogene 2008, 27:721-31; Cancer Lett. 2014 Feb 28;343(2):286-94).
  • shown that upregulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma (Cancer Res 2008, 67:1680-8).
  • demonstrated the potential therapeutic value of targeting PKC with the novel, orally available small-molecule inhibitor enzastaurin (Blood 2007, 109:1669-77).
  • demonstrated that the small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in MM (Proc Natl Acad Sci USA 2006, 103:19478-83). 

2010 – 2013

  • Podar K, Tonon G, Sattler M, Tai YT, Legouill S, Yasui H, Ishitsuka K, Kumar S, Kumar R, Pandite LN, Hideshima T, Chauhan D, Anderson KC. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma. Proc Natl Acad Sci U S A. 2006;103(51):19478-83.
  • Chauhan D, Singh AV, Brahmandam M, Carrasco R, Bandi M, Hideshima T, Bianchi G, Podar K, Tai YT, Mitsiades C, Raje N, Jaye DL, Kumar SK, Richardson P, Munshi N, Anderson KC. Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target. Cancer Cell. 2009;16(4):309-23.
  • Raab MS, Breitkreutz I, Tonon G, Zhang J, Hayden PJ, Nguyen T, Fruehauf JH, Lin BK, Chauhan D, Hideshima T, Munshi NC, Anderson KC, Podar K. Targeting PKC: A novel role for beta-catenin in ER stress and apoptotic signaling. Blood. 2009 Feb 12;113(7):1513-21.
  • Zhang J, Sattler M, Tonon G, Grabher C, Lababidi S, Zimmerhackl A, Raab MS, Vallet S, Zhou Y, Cartron MA, Hideshima T, Tai YT, Chauhan D, Anderson KC, Podar K. Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1{alpha}-Dependent Pathway in Multiple Myeloma. Cancer Res. 2009 Jun 15;69(12):5082-90.
  • Podar K, Zimmerhackl A, Fulciniti MT, Tonon G, Hainz U, Tai YT, Vallet S, Halama N, Jaeger D, Olson DL, Sattler M, Chauhan D, Anderson KC. The selective adhesion molecule (SAM) inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: Therapeutic implications. Br J Haematol. 2011; 155(4): 438-48
  • Fan F, Tonon G, Bashari MH, Vallet S, Antonini E, Goldschmidt H, Schulze- Bergkamen H, Opferman JT, Sattler M, Anderson KC, Jäger D, Podar K. Targeting Mcl-1 for multiple myeloma (MM) therapy: Drug- induced generation of Mcl-1 fragment Mcl-1128-350 triggers MM cell death via c- Jun upregulation. Cancer Lett. 2013

B. Braun Stifungsgrant



  • 1987 Highest Distinction, Gymnasium/ High School Wien XVI- Maroltingergasse, Vienna, Austria
  • 1994 Cum Laude, Medical University of Vienna, Vienna, Austria
  • 1998 Summa cum Laude, University of Vienna, Faculty of Nature Sciences, Vienna, Austria
  • 1998 PhD Distinct Stipend Grant Award, Vienna Biocenter, Vienna, Austria
  • 2001 IMF Research Grant Award, IMF
  • 2002 Summa cum Laude, University of Vienna, Faculty of Nature Sciences/ Harvard Medical School, Faculty of Medicine
  • 2002 IMF Research Grant Award, IMF
  • 2003 MMRF Senior Research Grant Award, MMRF
  • 2006 MMRF Senior Research Grant Award, MMRF
  • 2007 Dunkin' Donuts Rising Star 2007, Dunkin' Donuts
  • 2009 Who's Who in America (2009 edition), Marquis