Prof. Dr. Dr. Jürgen Hoffmann
Chairman of the Department of Oral and Maxillofacial Surgery

University Hospital Heidelberg
Im Neuenheimer Feld 400
69120 Heidelberg

Reconstruction of soft and hard tissue...


defects in the head and neck area.

Department of Oral and Maxillofacial Surgery


Our group/department has:

  • High-risk human papilloma virus types are not associated with the formation of oral squamous cell carcinoma in contrast to oropharyngeal squamous cell carcinoma (see 1)
  • TGF-β and NF-κB signalling pathways are critically involved in head and neck squamous cell carcinoma development (see 2)
  • Ki-67 has a predictive value for the risk of recurrence in early oral squamous cell carcinoma (see 3)
  • Head and neck squamous cell carcinoma cell lines have been cytogenetically characterized to be used as functional model systems for the evaluation of tumor-associated genetic aberrations (see 4)
  • Stem-cell associated transcription factor SOX2 is active in oral squamous cell carcinoma initiation and progression (see 5)

2010 – 2013

  • Reuschenbach M, Kansy K, Garbe K, Vinokurova S, Flechtenmacher C, Toth C, Prigge ES, Thiele OC, Reinert S, Hoffmann J, von Knebel Doeberitz M, Freier K. Lack of evidence of human papillomavirus-induced squamous cell carcinomas of the oral cavity in southern Germany. Oral Oncol. 2013; 49(9):937-42.
  • Freudlsperger C, Bian Y, Contag Wise S, Burnett J, Coupar J, Yang X, Chen Z, Van Waes C. TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers. Oncogene. 2013; 32(12):1549-59.
  • Freudlsperger C, Rohleder SE, Reinert S, Hoffmann J. Predictive value of high Ki-67 expression in stage I oral squamous cell carcinoma specimens after primary surgery. Head Neck. 2011; 33(5):668-72
  • Freier K, Hofele C, Knoepfle K, Gross M, Devens F, Dyckhoff G, Plinkert P, Lichter P, Herold-Mende C. Cytogenetic characterization of head and neck squamous cell carcinoma cell lines as model systems for the functional analyses of tumor-associated genes. J Oral Pathol Med. 2010; 39(5):382-9.
  • Freier K, Knoepfle K, Flechtenmacher C, Pungs S, Devens F, Toedt G, Hofele C, Joos S, Lichter P, Radlwimmer B. Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma. Genes Chromosomes Cancer. 2010; 49(1):9-16.