Contact

 

Prof. Dr. Hanno Glimm
Phone: +49 6221 566979
Fax: +49 6221 567234

E-mail: hanno.glimm@nct-heidelberg.de

 

 

Normal and malignant...

 

stem cell biology.

Applied Stem Cell Biology

DKFZ
 
 
 

Our group/department has:

  • described distinct types of tumor-initiating cells in tumor progression and metastasis formation in colon cancer (Cell Stem Cell 2011).

  • Targeted critical co-dependencies in colorectal cancer initiating cells (J Exp Med 2012) and targeted CD133+ colorectal cancer initiating cells with re-targeted oncolytic measles virus (Cancer Res 2013).

  • identified the role of MDS1/EVI1 gene activation in the development of clonal dominance and leukemia (Nat Med 2010; Cell Cycle 2012; PLoS One 2013).

  • described an intrinsically fixed differentiation program of human STRCs that changes during ontogeny (Stem Cells Dev 2010).

  • Analyzed the clonal behavior of genetically marked hematopoietic cells in unmanipulated murine hematopoiesis. (Stem Cells 2012).

2010 – 2013

  •  Voloshanenko O, Erdmann G, Dubash TD, Augustin I, Metzig M, Moffa G, Hundsrucker C, Kerr G, Sandmann T, Anchang B, Demir K, Boehm C, Leible S, Ball CR, Glimm H, Spang R, Boutros M (2013). Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nat Commun Oct 28;4:2610. doi: 10.1038/ncomms3610.

  • Zavidij O, Ball CR, Herbst F, Oppel F, Fessler S, Schmidt M, von Kalle C, Glimm H (2012). Stable Long-Term Blood Formation by Stem Cells in Murine Steady-State Hematopoiesis. Stem Cells 30(9):1961-70.

  • Azoitei N, Hoffmann CM, Ellegast JM, Ball CR, Obermayer K, Gößele U, Koch B, Faber K, Genze F, Schrader M, Kestler HA, Döhner H, Chiosis G, Glimm H, Fröhling S, Scholl C (2012). Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33. J Exp Med 209(4):697-711.

  • Dieter SM, Ball CR, Hoffmann CM, Nowrouzi A, Herbst F, Zavidij O, Abel U, Arens A, Weichert W, Brand K, Koch M, Weitz J, Schmidt M, von Kalle C, Glimm H (2011). Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell 9(4):357-65.

  • Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, Kinner A, Schmidt M, Krämer A, Schwäble J, Glimm H, Koehl U, Preiss C, Ball C, Martin H, Göhring G, Schwarzwaelder K, Hofmann WK, Karakaya K, Tchatchou S, Yang R, Reinecke P, Kühlcke K, Schlegelberger B, Thrasher AJ, Hoelzer D, Seger R, von Kalle C (co-corresponding), Grez M (2010). Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med 16(2):198-204.

  • Ongoing projects are funded by the DFG and the Baden-Württemberg Foundation and embedded into multiple cross-sectional activities at the Heidelberg campus (KFO 227 and SFB 873, Heidelberg Centre for Personalized Oncology (HIPO) and NCT Precision Oncology Program (POP)).

  • Sebastian Dieter: Preis der Dr. Feldbausch-Stiftung 2013

  • Sebastian Dieter: Vincenz-Czerny-Preis 2012

  • Oksana Zavidij: Reisestipendium Glaxo-Smith-Kline Stiftung, International Society of Stem Cell Research (ISSCR), 9th Annual Meeting, 2011

  • Friederike Herbst: Reisestipendium Glaxo-Smith-Kline Stiftung, International Society of Stem Cell Research (ISSCR), 8th Annual Meeting, 2010

  • Claudia Ball: Travel Award, International Society of Stem Cell Research (ISSCR), 8th Annual Meeting, 2010

  • Friederike Herbst: Reisestipendium der Heinrich-Behr-Stfitung, Spetses International Summer School 2010