- Established a pre-clinical mouse model of human Burkitt lymphoma (Sander et al. Cancer Cell 2012)
- Identified the PI3K signaling pathway as synergistic factor in MYC-driven lymphomagenesis and new druggable target in Burkitt lymphoma (Sander et al. Cancer Cell 2012)
- Characterized the function of the transcription factor FOXO1 during germinal center development (Sander et al. Immunity 2015)
Modeling B-cell lymphomagenesis...
in the mouse – from bench to bedside.
The Max Eder Research Group "Adaptive Immunity and Lymphoma" investigates cellular and molecular mechanisms underlying the germinal center (GC) reaction and lymphoma development. Based on this knowledge we aim to improve the treatment of lymphoma patients as well as to identify new approaches to enhance immune responses (e.g. in the context of vaccinations). With the help of innovative in vivo models that are characterized by selective targeting of genetic mutations in the cells of tumor origin, we are able to recapitulate human lymphomagenesis. These mouse models and state-of-the-art techniques in cancer biology and immunology will allow us to characterize tumor-specific aberrations and understand the transition from normal to malignant B-cells.
In particular, our research aims to
(I) identify disease relevant genes and pathways in lymphoma pathogenesis.
(II) analyze GC B-cell and lymphoma interactions with immune cells and the effect of this crosstalk on tumor growth.
(III) decipher B-cell receptor-mediated signaling as key pathway for B-cell and lymphoma survival and function.
(IV) develop new pre-clinical lymphoma models.
A broad range of methods is used to characterize and understand the germinal center (GC) reaction and GC B cell derived tumorigenesis.
Our group has:
- Sander S, Calado DP, Srinivasan L, Köchert K, Zhang B, Rosolowski M, Rodig SJ, Holzmann K, Stilgenbauer S, Siebert R, Bullinger L, Rajewsky K. Synergy between PI3K signalling and MYC in Burkitt lymphomagenesis. Cancer Cell. 2012, 22(2):167-79.
- Chu VT, Weber T, Wefers B, Wurst W, Sander S, Rajewsky K, Kühn R. Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat Biotechnol. 2015, 33(5):543-8.
- Sander S, Chu VT, Yasuda T, Franklin A, Graf R, Calado DP, Li S, Imami K, Selbach M, Di Virgilio M, Bullinger L, Rajewsky K. PI3 Kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones. Immunity 2015,43(6):1075-86.
- Deutsche Krebshilfe
- Else Kröner-Fresenius-Stiftung