The Department of Translational Oncology coordinates all major aspects of NCT´s further development and translational oncology at DKFZ. As part of the translational cancer research process, the department is deeply involved in the clinical activities of NCT and contributes to trial development, with a special focus on molecular diagnosis and therapy. The research program of the department focuses on Applied Stem Cell Research (Hanno Glimm), Molecular and Gene Therapy (Manfred Schmidt), Molecular and Cellular Oncology (Stefan Fröhling), Functional Genomics (Claudia Scholl), Molecular Therapy in Hematology and Oncology (Thorsten Zenz), Adaptive Immunity and Lymphoma (Dr. Dr. Sandrine Sander) and Virotherapy (Guy Ungerechts).
Towards personalized oncology, the department coordinates the development of the NCT Precision Oncology Program (NCT POP). NCT POP focuses all translational activities towards individualized cancer medicine, including patient-oriented strategies in genomics, proteomics, immunology, radiooncology, prevention, and early clinical development. The department has implemented the center-wide NCT MASTER (Molecularly Aided Stratification for Tumor Eradication) umbrella protocol. NCT MASTER makes it possible to perform and evaluate molecular diagnostics on materials from all consenting NCT patients, with the explicit purpose of stratifying each patient for the best treatment or trial strategy.