Salivary Gland

• Interdisciplinary patient management
• Interdisciplinary discussion and consultation hours for Head & Neck cancer
• Particle Therapy
• PET-CT assisted treatment decisions
• Treatment of tumor recurrence
• DKH and NCT funded prospective studies

• Three prospective randomized clinical trials on radiotherapy in head and neck cancer
• Translational studies (AG Abdollahi DKFZ)
• Cooperation with different work groups (AG Meier-Hein DKFZ; AG Sültmann; Prof. Schlemmer Radiology DKFZ)

• https://www.nct-heidelberg.de/en/for-physicians/studies.html
• GUARD
• CARE
• NAVIGATORR

Adeberg S, Akbaba S, Lang K, Held T, Verma V, Nikoghosyan A, Bernhardt D, Münter M, Freier K, Plinkert P, Hauswald H, Herfarth K, Rieken S, Debus J, Jensen AD. 
The Phase 1/2 ACCEPT Trial: Concurrent Cetuximab and Intensity Modulated Radiation Therapy with Carbon Ion Boost for Adenoid Cystic Carcinoma of the Head and Neck. 
Int J Radiat Oncol Biol Phys. 2020 Jan 1;106(1):167-173. doi: 10.1016/j.ijrobp.2019.09.036. PMID: 31586664.
(IF: 6,2)

Voronina N, Wong JKL, Hübschmann D, Hlevnjak M, Uhrig S, Heilig CE, Horak P, Kreutzfeldt S, Mock A, Stenzinger A, Hutter B, Fröhlich M, Brors B, Jahn A, Klink B, Gieldon L, Sieverling L, Feuerbach L, Chudasama P, Beck K, Kroiss M, Heining C, Möhrmann L, Fischer A, Schröck E, Glimm H, Zapatka M, Lichter P, Fröhling S, Ernst A. The landscape of chromothripsis across adult cancer types. 
Nat Commun. 2020 May 8;11(1):2320. doi: 10.1038/s41467-020-16134-7. PMID: 32385320.
(IF: 14,92)

Akbaba S, Ahmed D, Mock A, Held T, Bahadir S, Lang K, Syed M, Hoerner-Rieber J, Forster T, Federspil P, Herfarth K, Plinkert P, Debus J, Adeberg S. 
Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience. 
Cancers (Basel). 2019 Nov 1;11(11). pii: E1705. doi: 10.3390/cancers11111705. PubMed PMID: 31683896.
(IF: 6,1)

Held T, Windisch P, Akbaba S, Lang K, El Shafie R, Bernhardt D, Plinkert P, Kargus S, Rieken S, Herfarth K, Debus J, Adeberg S. 
Carbon Ion Reirradiation for Recurrent Head and Neck Cancer: A Single-Institutional Experience. Int J Radiat Oncol Biol Phys. 2019 Jul 23. pii: S0360-3016(19)33504-7. doi: 10.1016/j.ijrobp.2019.07.021. [Epub ahead of print] PubMed PMID: 31349059.
(IF: 6,2)

Syed M, Flechsig P, Liermann J, Windisch P, Staudinger F, Akbaba S, Koerber SA, Freudlsperger C, Plinkert PK, Debus J, Giesel F, Haberkorn U, Adeberg S.
Fibroblast activation protein inhibitor (FAPI) PET for diagnostics and advanced targeted radiotherapy in head and neck cancers. 
Eur J Nucl Med Mol Imaging. 2020 May 23. doi: 10.1007/s00259-020-04859-y. PMID: 32447444.
(IF: 7,18)

Feng B, Shen Y, Pastor Hostench X, Bieg M, Plath M, Ishaque N, Eils R, Freier K, Weichert W, Zaoui K, Hess J. Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer. Clin Cancer Res. 2020 Jul 15;26(14):3616-3628. doi: 10.1158/1078-0432.CCR-19-3997. PMID: 32161122.
(IF: 10,6)

Plath M, Gass J, Hlevnjak M, Li Q, Feng B, Hostench XP, Bieg M, Schroeder L, Holzinger D, Zapatka M, Freier K, Weichert W, Hess J, Zaoui K. Unraveling most abundant mutational signatures in head and neck cancer. Int J Cancer. 2021 Jan 1;148(1):115-127. doi: 10.1002/ijc.33297. PMID: 32930393.
(IF: 7,40)

Held T, Lang K, Regnery S, Weusthof K, Hommertgen A, Jäkel C, Tonndorf-Martini E, Krisam J, Plinkert P, Zaoui K, Freudlsperger C, Moratin J, Krauss J, Harrabi SB, Herfarth K, Debus J, Adeberg S. Carbon ion reirradiation compared to intensity-modulated re-radiotherapy for recurrent head and neck cancer (CARE): a randomized controlled trial. Radiat Oncol. 2020 Aug 5;15(1):190. doi: 10.1186/s13014-020-01625-0. PMID: 32758267.
(IF: 2,82)

Adeberg S, Windisch P, Ehret F, Baur M, Akbaba S, Held T, Bernhardt D, Haefner MF, Krauss J, Kargus S, Freudlsperger C, Plinkert P, Flechtenmacher C, Herfarth K, Debus J, Rieken S. Intensity Modulated Radiotherapy (IMRT) With Carbon Ion Boost in the Multimodal Treatment of Salivary Duct Carcinoma. Front Oncol. 2019 Dec 20;9:1420. doi: 10.3389/fonc.2019.01420. PMID: 31921675.
(IF: 4,85)

Akbaba S, Bostel T, Lang K, Bahadir S, Lipman D, Schmidberger H, Matthias C, Rotter N, Knopf A, Freudlsperger C, Plinkert P, Debus J, Adeberg S. Large German Multicenter Experience on the Treatment Outcome of 207 Patients With Adenoid Cystic Carcinoma of the Major Salivary Glands. Front Oncol. 2020 Nov 11;10:593379. doi: 10.3389/fonc.2020.593379. PMID: 33262950.
(IF: 4,85)

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