Clinical Trials

Urological Tumors

Recruitment stopped
Ongoing Recruitment

Prostata Carcinoma

g-RAMPP-Studie

(first-line)
Title:Multicentric, Prospective, Randomized Controlled Trial Comparing Radical Prostatectomy Plus Neoadjuvant Hormones With Androgen Deprivation Therapy Alone in the Management of Men With Pauci-metastatic Prostate Cancer
Indication:Prostatic Neoplasms
Type of study:Phase N/A
Contact: Helga Gutzler (Kontaktperson)
[helga.gutzler@med.uni-heidelberg.de]
Investigator: Dr. Tobias Simpfendörfer (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02454543
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

NCT-PMO-1603 TOP-ART

(second-line, BRCAness)
Title:A Randomized Phase-2 Study of Trabectedin/Olaparib Compared to Physician's Choice in Subjects With Previously Treated Advanced or Recurrent Solid Tumors Harboring DNA Repair Deficiencies
Indication:DNA Repair-Deficiency Disorders
Type of study:Phase II
Contact: Barbara Stöhr (Study Nurse)
[barbara.stoehr@nct-heidelberg.de]
Investigator: Prof. Dr. Stefan Fröhling (Leiter klinische Prüfung)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03127215
EudraCT: 2017-001755-31 (siehe EU klinisches Studienregister)

Probase

(diagnostisch, Früherkennung, Screening)
Title:Risk-adapted prostate cancer early detection study based on a “baseline” PSA value in young men – a prospective multicenter randomized trial
Indication:Diagnosis of prostate cancer
Type of study:Phase N/A
Contact: Jutta von Kraewel (Kontaktperson)
[Jutta.Kraewel@med.uni-heidelberg.de]
Investigator: Prof. Dr. Markus Hohenfellner (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Retest- Studie

(diagnostisch, Früherkennung, Screening)
Title:Wiederholung kontrastmittelfreier MRT Sequenzen am selben Tag nach erfolgter vollständiger Prostata MRT zur Bestimmung radiomischer Parameterstabilität
Indication:prostate cancer
Type of study:Phase N/A
Contact: Radiologie DKFZ (Kontaktperson)
[-]
Investigator: PD Dr. med. David Bonekamp (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

68-Ga-PMSA-PET_CT und PET_MRT_ Prostata-Ca

(diagnostisch, Screening)
Title:Vergleich der diagnostischen Genauigkeit von 68Ga-PSMA-PET/CT und -PET/MRT beim präoperativen Staging bzw. Re-Staging von Patienten mit gesichertem oder klinischem Verdacht auf ein Prostatakarzinom.
Indication:n.a.
Type of study:Phase N/A
Contact: Dr. med. Matthias C. Roethke (Kontaktperson)
[m.roethke@dkfz.de]
Investigator: Dr. med. Matthias C. Roethke (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

PLATIN

(radiologisch)
Title:Randomised Trial of Proton vs. Carbon Ion Radiation Therapy in Patients With Low and Inter-mediate Grade Chondrosarcoma of the Skull Base, Clinical Phase III
Indication:Prostata-Ca mit entweder hohem Lymphknotenbefallsrisiko oder nachgewiesenen pelvinen Lymphknotenbefall.
Type of study:Phase II
Contact: Renate Haselmann (Study Nurse)
[renate.haselmann@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Leiter klinische Prüfung)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

LAP-01

(supportive care trial, chirurgisch)
Title:Randomisierte, multizentrische Studie zum Vergleich der roboterassistierten und der konventionellen laparoskopischen radikalen Prostatektomie
Indication:prostate cancer
Type of study:Phase N/A
Contact: Helga Gutzler (Kontaktperson)
[helga.gutzler@med.uni-heidelberg.de]
Investigator: Dr.med Joanne Nyarangi-Dix (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Bocciardi

Title:Retziussparende radikale Prostatektomie (Bocciardi Technik) . Evaluation der Bocciardi Technik für die daVinci assistierte Prostatektomie.
Indication:Prostatakrebs
Type of study:Phase N/A
Contact: Helga Gutzler (Study Nurse)
[helga.gutzler@med.uni-heidelberg.de]
Investigator: Dr.med Joanne Nyarangi-Dix (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

CA209-9KD

Title:A Phase 2 Study of Nivolumab in Combination With Either Rucaparib, Docetaxel, or Enzalutamide in Men With Castration-resistant Metastatic Prostate Cancer
Indication:Prostatic Neoplasms
Type of study:Phase II
Contact: Margit Peters-Hornig (Study Nurse)
[margit.peters-hornig@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03338790
EudraCT: 2017-001626-17 (siehe EU klinisches Studienregister)

TITAN TCC

Title:A Phase II Single Arm Clinical Trial of a Tailored ImmunoTherapy Approach With Nivolumab in Subjects With Metastatic or Advanced Transitional Cell Carcinoma
Indication:Carcinoma Neoplasm Metastasis Carcinoma, Transitional Cell
Type of study:Phase II
Contact: Ulrike Lauterbach (Study Nurse)
[Ulrike.Lauterbach@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03219775
EudraCT: 2016-004857-33 (siehe EU klinisches Studienregister)

TRITON 2/CO-338-052

Title:A Multicenter, Open-label Phase 2 Study of Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer Associated with Homologous Recombination Deficiency
Indication:Metastatic castration-resistant prostate cancer
Type of study:Phase II
Contact: Margit Peters-Hornig (Study Nurse)
[margit.peters-hornig@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02952534
EudraCT: 2016-003162-13 (siehe EU klinisches Studienregister)

TULSA (Profound)

Title:Evaluation of the TULSA-PRO MRI-Guided Transurethral Ultrasound Prostate Ablation Device in Patients With Localized Prostate Cancer: a Prospective, Single-Arm, Pivotal Clinical Study
Indication:Prostatic Neoplasms
Type of study:Phase II
Contact: Radiologie DKFZ (Kontaktperson)
[-]
Investigator: PD Dr. med. David Bonekamp (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02766543
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Renal Carcinoma

WO39760

(first-line, metastasiert, therapeutisch)
Title:A Phase II, Open-Label, Multicenter, Multicohort Study to Investigate the Efficacy and Safety of Cobimetinib Plus Atezolizumab in Patients With Solid Tumors
Indication:Advanced solid tumors including squamous cell carcinoma of the head and neck (SCCHN), urothelial carcinoma, and renal cell carcinoma (RCC).
Type of study:Phase II
Contact: Margit Peters-Hornig (Study Nurse)
[margit.peters-hornig@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03264066
EudraCT: 2017-000794-37 (siehe EU klinisches Studienregister)

NCT-PMO-1603 TOP-ART

(second-line, BRCAness)
Title:A Randomized Phase-2 Study of Trabectedin/Olaparib Compared to Physician's Choice in Subjects With Previously Treated Advanced or Recurrent Solid Tumors Harboring DNA Repair Deficiencies
Indication:DNA Repair-Deficiency Disorders
Type of study:Phase II
Contact: Barbara Stöhr (Study Nurse)
[barbara.stoehr@nct-heidelberg.de]
Investigator: Prof. Dr. Stefan Fröhling (Leiter klinische Prüfung)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03127215
EudraCT: 2017-001755-31 (siehe EU klinisches Studienregister)

SIOP 2001 / GPOH

(pädiatrisch)
Title:Phase III trial to study the effectiveness of chemotherapy before and after surgery in treating children who have Wilm's tumor.
Indication:Carcinoma, Renal Cell, Kidney Neoplasms, Wilms Tumor
Type of study:Phase III
Contact: Donate Jakoby (Study Nurse)
[donate.jakoby@med.uni-heidelberg.de]
Investigator: Dr. med. Wolfgang Behnisch (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT00047138
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Immotion 010 (WO39210)

Title:A Phase III, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of Atezolizumab (Anti-PD-L1 Antibody) as Adjuvant Therapy in Patients With Renal Cell Carcinoma at High Risk of Developing Metastasis Following Nephrectomy
Indication:CarcinomaCarcinoma, Renal Cell
Type of study:Phase III
Contact: Stefanie Zschäbitz (Study Nurse)
[stefanie.zschaebitz@nct-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03024996
EudraCT: 2016-001881-27 (siehe EU klinisches Studienregister)

STARTRK-2/ RXDX-101-92

Title:AN OPEN-LABEL, MULTICENTER, GLOBAL PHASE 2 BASKET STUDY OF ENTRECTINIB FOR THE TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS THAT HARBOR NTRK1/2/3, ROS1, OR ALK GENE REARRANGEMENTS
Indication:Locally Advanced or Metastatic Solid Tumors that Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Type of study:Phase II
Contact: Stefanie Hofmann (Study Nurse)
[stefanie.hofmann@med.uni-heidelberg.de]
Investigator: Dr. med. Christoph Springfeld (Prüfer)
Trial Register: No trial registry number given.
EudraCT: 2015-003385-84 (siehe EU klinisches Studienregister)

SUNNIFORECAST

Title:A Phase 2, Randomized, Open-Label Study of Nivolumab Combined With Ipilimumab Versus Sunitinib Monotherapy in Subjects With Previously Untreated and Advanced (Unresectable or Metastatic) Non-clear Cell Renal Cell Carcinoma (nccRCC)
Indication:CarcinomaCarcinoma, Renal Cell
Type of study:Phase II
Contact: Stefanie Hofmann (Study Nurse)
[stefanie.hofmann@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: No trial registry number given.
EudraCT: 2016-000706-12 (siehe EU klinisches Studienregister)

TITAN TCC

Title:A Phase II Single Arm Clinical Trial of a Tailored ImmunoTherapy Approach With Nivolumab in Subjects With Metastatic or Advanced Transitional Cell Carcinoma
Indication:Carcinoma Neoplasm Metastasis Carcinoma, Transitional Cell
Type of study:Phase II
Contact: Ulrike Lauterbach (Study Nurse)
[Ulrike.Lauterbach@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03219775
EudraCT: 2016-004857-33 (siehe EU klinisches Studienregister)

Vaccibody (VBN-01)

Title:An open labelled first human dose phase 1/2a study to evaluate safety, feasibility and efficacy of multiple dosing with individualised VB10.NEO immunotherapy in patients with locally advanced or metastatic melanoma, NSCLC, clear renal cell carcinoma, urothelial cancer or squamous cell carcinoma of head and neck, who did not reach complete responses with current standard of care immune checkpoint blockade
Indication:Locally advanced or metastatic solid tumours including melanoma, NSCLC, clear renal cell carcinoma, urothelial cancer or SCCHN
Type of study:Phase I
Contact: Sebastian Schülke (Kontaktperson)
[Sebastian.Schuelke@med.uni-heidelberg.de]
Investigator: PD Dr. med. Jürgen Krauss (Leiter klinische Prüfung)
Trial Register: No trial registry number given.
EudraCT: 2017-002474-39 (siehe EU klinisches Studienregister)

Urothelial Carcinoma

WO39760

(first-line, metastasiert, therapeutisch)
Title:A Phase II, Open-Label, Multicenter, Multicohort Study to Investigate the Efficacy and Safety of Cobimetinib Plus Atezolizumab in Patients With Solid Tumors
Indication:Advanced solid tumors including squamous cell carcinoma of the head and neck (SCCHN), urothelial carcinoma, and renal cell carcinoma (RCC).
Type of study:Phase II
Contact: Margit Peters-Hornig (Study Nurse)
[margit.peters-hornig@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03264066
EudraCT: 2017-000794-37 (siehe EU klinisches Studienregister)

BMS CA 209-274

(second-line)
Title:A Phase 3 Randomized, Double-blind, Multi-center Study of Adjuvant Nivolumab Versus Placebo in Subjects With High Risk Invasive Urothelial Carcinoma (CheckMate 274: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 274)
Indication:Carcinoma, Transitional Cell
Type of study:Phase III
Contact: Ute Bickelhaupt (Kontaktperson)
[Ute.Bickelhaupt@med.uni-heidelberg.de]
Investigator: Dr. Gencay Hatiboglu (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02632409
EudraCT: 2014-003626-40 (siehe EU klinisches Studienregister)

FIERCE-22/B-701-U22

Title:A Multi-Center, Open-Label Phase 1b/2 Study of a Novel FGFR3 Inhibitor (B-701) Combined with Pembrolizumab in Subjects with Locally Advanced or Metastatic Urothelial Carcinoma who have Progressed Following Platinum-based Chemotherapy.
Indication:Locally Advanced or Metastatic Urothelial Cell Carcinoma, Urinary Bladder Disease, Urological Diseases
Type of study:Phase II
Contact: Margit Peters-Hornig (Study Nurse)
[margit.peters-hornig@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03123055
EudraCT: 2017-001292-23 (siehe EU klinisches Studienregister)

STARTRK-2/ RXDX-101-92

Title:AN OPEN-LABEL, MULTICENTER, GLOBAL PHASE 2 BASKET STUDY OF ENTRECTINIB FOR THE TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS THAT HARBOR NTRK1/2/3, ROS1, OR ALK GENE REARRANGEMENTS
Indication:Locally Advanced or Metastatic Solid Tumors that Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Type of study:Phase II
Contact: Stefanie Hofmann (Study Nurse)
[stefanie.hofmann@med.uni-heidelberg.de]
Investigator: Dr. med. Christoph Springfeld (Prüfer)
Trial Register: No trial registry number given.
EudraCT: 2015-003385-84 (siehe EU klinisches Studienregister)

TITAN TCC

Title:A Phase II Single Arm Clinical Trial of a Tailored ImmunoTherapy Approach With Nivolumab in Subjects With Metastatic or Advanced Transitional Cell Carcinoma
Indication:Carcinoma Neoplasm Metastasis Carcinoma, Transitional Cell
Type of study:Phase II
Contact: Ulrike Lauterbach (Study Nurse)
[Ulrike.Lauterbach@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03219775
EudraCT: 2016-004857-33 (siehe EU klinisches Studienregister)

Vaccibody (VBN-01)

Title:An open labelled first human dose phase 1/2a study to evaluate safety, feasibility and efficacy of multiple dosing with individualised VB10.NEO immunotherapy in patients with locally advanced or metastatic melanoma, NSCLC, clear renal cell carcinoma, urothelial cancer or squamous cell carcinoma of head and neck, who did not reach complete responses with current standard of care immune checkpoint blockade
Indication:Locally advanced or metastatic solid tumours including melanoma, NSCLC, clear renal cell carcinoma, urothelial cancer or SCCHN
Type of study:Phase I
Contact: Sebastian Schülke (Kontaktperson)
[Sebastian.Schuelke@med.uni-heidelberg.de]
Investigator: PD Dr. med. Jürgen Krauss (Leiter klinische Prüfung)
Trial Register: No trial registry number given.
EudraCT: 2017-002474-39 (siehe EU klinisches Studienregister)