Clinical Trials

Urological Tumors

Recruitment stopped
Ongoing Recruitment

Prostata Carcinoma

MORE

(first-line, Biomarker)
Title:Molecular Determinants for Therapy Response on Renal Cell Carcinoma
Indication:Carcinoma, Renal Cell
Type of study:Phase N/A
Contact: Dr. Svenja Dieffenbacher (Kontaktperson)
[Svenja.Dieffenbacher@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02208128
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

g-RAMPP-Studie

(first-line)
Title:Multicentric, Prospective, Randomized Controlled Trial Comparing Radical Prostatectomy Plus Neoadjuvant Hormones With Androgen Deprivation Therapy Alone in the Management of Men With Pauci-metastatic Prostate Cancer
Indication:Prostatic Neoplasms
Type of study:Phase N/A
Contact: Helga Gutzler (Kontaktperson)
[helga.gutzler@med.uni-heidelberg.de]
Investigator: Dr. Tobias Simpfendörfer (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02454543
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

PROFOUND / D081DC00007

(second-line)
Title:A Phase III, Open Label, Randomized Study to Assess the Efficacy and Safety of Olaparib (Lynparza™) Versus Enzalutamide or Abiraterone Acetate in Men With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Prior Treatment With a New Hormonal Agent and Have Homologous Recombination Repair Gene Mutations (PROfound)
Indication:Prostatic Neoplasms
Type of study:Phase III
Contact: Margit Peters-Hornig (Study Nurse)
[margit.peters-hornig@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02987543
EudraCT: 2016-000300-28 (siehe EU klinisches Studienregister)

Probase

(diagnostisch, Früherkennung, Screening)
Title:Risk-adapted prostate cancer early detection study based on a “baseline” PSA value in young men – a prospective multicenter randomized trial
Indication:Diagnosis of prostate cancer
Type of study:Phase N/A
Contact: Jutta von Kraewel-Beyreiss (Kontaktperson)
[Jutta.Kraewel-Beyreiss@med.uni-heidelberg.de]
Investigator: Prof. Dr. Markus Hohenfellner (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Retest- Studie

(diagnostisch, Früherkennung, Screening)
Title:Wiederholung kontrastmittelfreier MRT Sequenzen am selben Tag nach erfolgter vollständiger Prostata MRT zur Bestimmung radiomischer Parameterstabilität
Indication:prostate cancer
Type of study:Phase N/A
Contact: Radiologie DKFZ (Kontaktperson)
[-]
Investigator: PD Dr. med. David Bonekamp (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

68-Ga-PMSA-PET_CT und PET_MRT_ Prostata-Ca

(diagnostisch, Screening)
Title:Vergleich der diagnostischen Genauigkeit von 68Ga-PSMA-PET/CT und -PET/MRT beim präoperativen Staging bzw. Re-Staging von Patienten mit gesichertem oder klinischem Verdacht auf ein Prostatakarzinom.
Indication:n.a.
Type of study:Phase N/A
Contact: Dr. med. Matthias C. Roethke (Kontaktperson)
[m.roethke@dkfz.de]
Investigator: Dr. med. Matthias C. Roethke (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

MOMENTUM

(epidemiologisch, Sport u. Bewegung)
Title:Social Cognitions and Norms Towards Physical Exercise Among Cancer Patients and Health Care Professionals
Indication:Colorectal Cancer, Breast Cancer, Prostate Cancer
Type of study:Phase I/II
Contact: Nadine Ungar (Study Nurse)
[nadine.ungar@nct-heidelberg.de]
Investigator: Dr. Joachim Wiskemann (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02678832
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

KOLOG

(radiologisch)
Title:KOhlenstoffionentherapie der ProstataLOGe
Indication:Prostata
Type of study:Phase II
Contact: Prof. Dr. med. Jürgen Debus (Kontaktperson)
[juergen.debus@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Klaus Herfarth (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

PLATIN

(radiologisch)
Title:Randomised Trial of Proton vs. Carbon Ion Radiation Therapy in Patients With Low and Inter-mediate Grade Chondrosarcoma of the Skull Base, Clinical Phase III
Indication:Prostata-Ca mit entweder hohem Lymphknotenbefallsrisiko oder nachgewiesenen pelvinen Lymphknotenbefall.
Type of study:Phase II
Contact: Renate Haselmann (Study Nurse)
[renate.haselmann@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Leiter klinische Prüfung)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

PROTEST

(radiologisch)
Title:PR0statakarzinom: TESTosteronspiegel nach Bestrahlung
Indication:Prostate cancer
Type of study:Phase N/A
Contact: Dr. med. Stefan Körber (Kontaktperson)
[stefan.körber@med.uni-heidelberg.de]
Investigator: Dr. med. Stefan Körber (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

LAP-01

(supportive care trial, chirurgisch)
Title:Randomisierte, multizentrische Studie zum Vergleich der roboterassistierten und der konventionellen laparoskopischen radikalen Prostatektomie
Indication:prostate cancer
Type of study:Phase N/A
Contact: Helga Gutzler (Kontaktperson)
[helga.gutzler@med.uni-heidelberg.de]
Investigator: PD Dr. Dogu Teber (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

PIVOTAL Trail (Nachfolge Profound-Studie)

Title:Evaluation of the Savety and Efficacy of the TULSA-PRO MRI-Guided Transurethral Ultrasound Therapy 'Deivice für Prostate Ablation in Patients with Localized Prostate Cancer: a prospektive, mulit-center, single arm, Pivotal Clinical Study
Indication:prostate cancer
Type of study:Phase N/A
Contact: Jutta von Kraewel-Beyreiss (Kontaktperson)
[Jutta.Kraewel-Beyreiss@med.uni-heidelberg.de]
Investigator: Dr. Gencay Hatiboglu (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

PREFERE-Studie

Title:Preference Based Randomized Trial for Evaluation of Four Treatment Modalities in Prostate Cancer With Low or "Early Intermediate" Risk
Indication:Prostatic Neoplasms
Type of study:Phase N/A
Contact: Jutta von Kraewel-Beyreiss (Kontaktperson)
[Jutta.Kraewel-Beyreiss@med.uni-heidelberg.de]
Investigator: PD Dr. med. Boris Hadaschik (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT01717677
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Precision-Studie

Title:Nachweis klinisch relevanter Prostatatumoren - Biopsie mit oder ohne MRT-Fusion
Indication:Prostate Cancer
Type of study:Phase N/A
Contact: Helga Gutzler (Kontaktperson)
[helga.gutzler@med.uni-heidelberg.de]
Investigator: Dr. Jan Philipp Radtke (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

TULSA (Profound)

Title:Evaluation of the TULSA-PRO MRI-Guided Transurethral Ultrasound Prostate Ablation Device in Patients With Localized Prostate Cancer: a Prospective, Single-Arm, Pivotal Clinical Study
Indication:Prostatic Neoplasms
Type of study:Phase II
Contact: Radiologie DKFZ (Kontaktperson)
[-]
Investigator: PD Dr. med. David Bonekamp (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02766543
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Renal Carcinoma

Aveo TIVO-03 / AV-951-15-303

(second-line)
Title:A Phase 3, Randomized, Controlled, Multi-Center, Open-Label Study to Compare Tivozanib Hydrochloride to Sorafenib in Subjects With Refractory Advanced Renal Cell Carcinoma
Indication:Carcinoma, Renal Cell
Type of study:Phase III
Contact: Alexandra Hestermann (Kontaktperson)
[alexandra.hestermann@med.uni-heidelberg.de]
Investigator: Dr. Gencay Hatiboglu (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02627963
EudraCT: 2015-003607-30 (siehe EU klinisches Studienregister)

SIOP 2001 / GPOH

(pädiatrisch)
Title:Phase III trial to study the effectiveness of chemotherapy before and after surgery in treating children who have Wilm's tumor.
Indication:Carcinoma, Renal Cell, Kidney Neoplasms, Wilms Tumor
Type of study:Phase III
Contact: Donate Jakoby (Study Nurse)
[donate.jakoby@med.uni-heidelberg.de]
Investigator: Dr. med. Wolfgang Behnisch (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT00047138
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

EuRhab 2010

(pädiatrisch, epidemiologisch)
Title:EU­RO­PEAN RHAB­DO­ID RE­GIS­TRY
Indication:Rhab­do­ide Tu­mo­ren jeg­li­cher ana­to­mi­schen Lo­ka­li­sa­ti­on
Type of study:Phase N/A
Contact: Renate Sedlak (Study Nurse)
[renate.sedlak@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Olaf Witt (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

More (NIS mit Urologie in Kombination mit NIS Pazoreal)

Title:NIS mit Urologie in Kombination mit NIS Pazoreal
Indication:prostate cancer
Type of study:Phase
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Nivoswitch

Title:1st-line, Phase II mit NIVO or continuation of therapy as an erarly SWITCH approach in pat. With mRCC and diesease control after 3 months of treatment with a tyrosine inhibitor
Indication:renal carcinoma
Type of study:Phase II
Contact: Julia Weck (Study Nurse)
[julia.weck@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: No trial registry number given.
EudraCT: 2016-002170-13 (siehe EU klinisches Studienregister)

Urothelial Carcinoma

B9991003 / JAVELIN Renal 101

(first-line)
Title:A Phase 3, Multinational, Randomized, Open-Label, Parallel-Arm Study Of Avelumab (MSB0010718C) In Combination With Axitinib (Inlyta(Registered)) Versus Sunitinib (Sutent(Registered)) Monotherapy In The First-Line Treatment Of Patients With Advanced Renal Cell Carcinoma
Indication:Carcinoma, Renal Cell
Type of study:Phase III
Contact: Margit Peters-Hornig (Study Nurse)
[margit.peters-hornig@med.uni-heidelberg.de]
Investigator: Dr. med. Carsten Grüllich (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02684006
EudraCT: 2015-002429-20 (siehe EU klinisches Studienregister)

Janssen BLC 2001 (42756493BLC2001)

(first-line)
Title:A Phase 2, Two-arm Multicenter, Open-Label Study to Determine the Efficacy and the Safety of Two Different Dose Regimens of a Pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493 in Subjects With Metastatic or Surgically Unresectable Urothelial Cancer With FGFR Genomic Alterations
Indication:Urothelial Cancer
Type of study:Phase II
Contact: Jutta von Kraewel-Beyreiss (Kontaktperson)
[Jutta.Kraewel-Beyreiss@med.uni-heidelberg.de]
Investigator: Dr. Björn Georgi (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02365597
EudraCT: 2014-002408-26 (siehe EU klinisches Studienregister)

BMS CA 209-274

(second-line)
Title:A Phase 3 Randomized, Double-blind, Multi-center Study of Adjuvant Nivolumab Versus Placebo in Subjects With High Risk Invasive Urothelial Carcinoma (CheckMate 274: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 274)
Indication:Carcinoma, Transitional Cell
Type of study:Phase III
Contact: Alexandra Hestermann (Kontaktperson)
[alexandra.hestermann@med.uni-heidelberg.de]
Investigator: Dr. Gencay Hatiboglu (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02632409
EudraCT: 2014-003626-40 (siehe EU klinisches Studienregister)