Clinical Trials

Soft Tissue and Bone Tumors

Recruitment stopped
Ongoing Recruitment

Ewing 2008 / EWING2008

(neoadjuvant, pädiatrisch)
Title:Phase 3, Open Label, Multi-centre, Randomised Controlled International Study in Ewing Sarcoma
Indication:Ewing's Sarcoma
Type of study:Phase III
Contact: Renate Sedlak (Study Nurse)
[renate.sedlak@med.uni-heidelberg.de]
Investigator: PD Dr. med. Gerlinde Egerer (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT00987636
EudraCT: 2008-003658-13 (siehe EU klinisches Studienregister)

OSCAR

(adjuvant, pädiatrisch, radiologisch)
Title:Therapy Trial to Determine the Safety and Efficacy of Heavy Ion Radiotherapy in Patients with Osteosarcoma
Indication:Osteosarcoma
Type of study:Phase I/II
Contact: Karen Lossner (Study Nurse)
[Karen.lossner@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT01005043
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

NCT-PMO-1603 TOP-ART

(second-line, BRCAness)
Title:A Randomized Phase-2 Study of Trabectedin/Olaparib Compared to Physician's Choice in Subjects With Previously Treated Advanced or Recurrent Solid Tumors Harboring DNA Repair Deficiencies
Indication:DNA Repair-Deficiency Disorders
Type of study:Phase II
Contact: Barbara Stöhr (Study Nurse)
[barbara.stoehr@nct-heidelberg.de]
Investigator: Prof. Dr. Stefan Fröhling (Leiter klinische Prüfung)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03127215
EudraCT: 2017-001755-31 (siehe EU klinisches Studienregister)

PMO-1601

(second-line, therapeutisch, p16 deletiert, CDKN2A/B deletiert)
Title:CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma (NCT-PMO-1601)
Indication:Chordoma
Type of study:Phase II
Contact: Barbara Stöhr (Study Nurse)
[barbara.stoehr@nct-heidelberg.de]
Investigator: Prof. Dr. Stefan Fröhling (Leiter klinische Prüfung)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03110744
EudraCT: 2016-004660-19 (siehe EU klinisches Studienregister)

YonSar-Studie (ET-D-023-13)

(epidemiologisch)
Title:Non-interventional Study to Investigate Efficacy and Safety of Trabectedin (Yondelis®) in Patients With Advanced Soft Tissue Sarcoma
Indication:Sarcoma
Type of study:Phase N/A
Contact: Martina Gronkowski (Kontaktperson)
[martina.gronkowski@med.uni-heidelberg.de]
Investigator: PD Dr. med. Gerlinde Egerer (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02367924
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

INFORM

(pädiatrisch, supportive care trial)
Title:INFORM – INdividualized Therapy FOr Relapsed Malignancies in Childhood Coordinating Investigator Registry
Indication:pediatric patients with relapsed or refractory high risk disease. Refractory/relapsed/progressive ALL-HR, ALL post-SCT, AML, CWS/rhabdomyosarcoma, ependymoma and medulloblastoma, ewing sarcoma, high grade glioma (incl. DIPG), neuroblastoma, NHL, osteosarcoma, rhabdoid tumors, “other”
Type of study:Phase N/A
Contact: Donate Jakoby (Study Nurse)
[donate.jakoby@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Olaf Witt (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

CHONDROSARKOM (CSP12C)

(Schwerionentherapie, radiologisch)
Title:Randomised Trial of Proton vs. Carbon Ion Radiation Therapy in Patients With Low and Inter-mediate Grade Chondrosarcoma of the Skull Base, Clinical Phase III Study
Indication:Chondrosarcoma
Type of study:Phase III
Investigator: Prof. Dr. med. Jürgen Debus (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT01182753
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

CHORDOM (HIT-1 / CH.P.12C)

(Schwerionentherapie, radiologisch)
Title:Randomised Trial of Proton vs. Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base -Clinical Phase III Study
Indication:Chordoma
Type of study:Phase III
Contact: Renate Haselmann (Study Nurse)
[renate.haselmann@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT01182779
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

AIO-STS-0415

Title:Eine randomisierte Phase-II-Studie mit Durvalumab und Tremelimumab im Vergleich zu Doxorubicin bei Patienten mit fortgeschrittenem oder metastasiertem Weichteilsarkom.
Indication:fortgeschrittenes oder metastasiertes Weichteilsarkom
Type of study:Phase II
Contact: Martina Gronkowski (Study Nurse)
[martina.gronkowski@med.uni-heidelberg.de]
Investigator: PD Dr. med. Gerlinde Egerer (Prüfer)
Trial Register: No trial registry number given.
EudraCT: 2016-004750-15 (siehe EU klinisches Studienregister)

E-Trab-Studie

Title:Geriatric assessment of elderly “unsuited” patients receiving trabectedin in first line treatment for advanced soft tissue sarcomas (STS)
Indication:Sarkom
Type of study:Phase N/A
Contact: Martina Gronkowski (Study Nurse)
[martina.gronkowski@med.uni-heidelberg.de]
Investigator: PD Dr. med. Gerlinde Egerer (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

IRON-2

Title:Intensity-modulated Radiotherapy With Integrated-boost in Patients With Spinal Bone Metastases
Indication:Neoplasm MetastasisNeoplasms, Second Primary
Type of study:Phase II
Contact: Dr. med. Tanja Sprave (Kontaktperson)
[tanja.sprave@med.uni-heidelberg.de]
Investigator: PD Dr. Dr. med. Harald Rief (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02832765
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

ReTraSarc Studie

Title:Retrospective study to evaluate efficacy and safety of Trabectedin (Yondelis®) in Sarcoma patients
Indication:Sarkom
Type of study:Phase N/A
Contact: Martina Gronkowski (Study Nurse)
[martina.gronkowski@med.uni-heidelberg.de]
Investigator: PD Dr. med. Gerlinde Egerer (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

STARTRK-2/ RXDX-101-92

Title:AN OPEN-LABEL, MULTICENTER, GLOBAL PHASE 2 BASKET STUDY OF ENTRECTINIB FOR THE TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS THAT HARBOR NTRK1/2/3, ROS1, OR ALK GENE REARRANGEMENTS
Indication:Locally Advanced or Metastatic Solid Tumors that Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Type of study:Phase II
Contact: Stefanie Hofmann (Study Nurse)
[stefanie.hofmann@med.uni-heidelberg.de]
Investigator: Dr. med. Christoph Springfeld (Prüfer)
Trial Register: No trial registry number given.
EudraCT: 2015-003385-84 (siehe EU klinisches Studienregister)