Clinical Trials

Neurooncologic Tumors

Recruitment stopped
Ongoing Recruitment

BAY 1436032 / 18239

(adjuvant)
Title:An Open-label, Non-randomized, Multicenter Phase I Study to Determine the Maximum Tolerated or Recommended Phase II Dose of Oral Mutant IDH1 Inhibitor BAY 1436032 and to Characterize Its Safety, Tolerability, Pharmacokinetics and Preliminary Pharmacodynamic and Anti-tumor Activity in Patients With IDH1-R132X-mutant Advanced Solid Tumors
Indication:IDH1-mutant advanced solid tumors
Type of study:Phase I
Contact: Anja Schumann (Kontaktperson)
[Anja.Schumann@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Wolfgang Wick (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02746081
EudraCT: 2015-003483-37 (siehe EU klinisches Studienregister)

BMS 209-548 (MGMT-Methylated Glioblastoma)

(adjuvant)
Title:A Randomized Phase 2 Single Blind Study of Temozolomide Plus Radiation Therapy Combined With Nivolumab or Placebo in Newly Diagnosed Adult Subjects With MGMT-Methylated (Tumor O6-methylguanine DNA Methyltransferase) Glioblastoma - CheckMate 548: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 548
Indication:Glioblastoma, Brain Neoplasms
Type of study:Phase II
Contact: Andrea Dormann (Kontaktperson)
[andrea.dormann@med.uni-heidelberg.de]
Investigator: Dr. med. Antje Wick (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02667587
EudraCT: 2015-004722-34 (siehe EU klinisches Studienregister)

RTOG 3508/AbbVie M13-813

(adjuvant)
Title:A Randomized, Placebo Controlled Phase 2b/3 Study of ABT-414 With Concurrent Chemoradiation and Adjuvant Temozolomide in Subjects With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification (Intellance 1)
Indication:Glioblastoma Gliosarcoma
Type of study:Phase II/III
Contact: Daniela Hall (Kontaktperson)
[ksc@med.uni-heidelberg.de]
Investigator: Dr. med. Antje Wick (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02573324
EudraCT: 2015-001166-26 (siehe EU klinisches Studienregister)

STELLAR Study (OT-15-001)

(adjuvant)
Title:A Randomized Phase 3 Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine With Lomustine Compared to Lomustine Alone in Patients With AA That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy
Indication:Astrocytoma
Type of study:Phase III
Contact: Daniela Hall (Kontaktperson)
[ksc@med.uni-heidelberg.de]
Investigator: Dr. med. Antje Wick (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02796261
EudraCT: 2016-000089-45 (siehe EU klinisches Studienregister)

RIST-rNB-2011

(pädiatrisch)
Title:Prospective, Open Label, Randomized Phase II Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-risk Neuroblastoma
Indication:Neuroblastoma
Type of study:Phase II
Contact: Donate Jakoby (Study Nurse)
[donate.jakoby@med.uni-heidelberg.de]
Investigator: PD Dr. med. Johann Greil (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT01467986
EudraCT: 2011-004062-15 (siehe EU klinisches Studienregister)

SIOP CNS GCT II (UKM08_0057)

(pädiatrisch)
Title:SIOP CNS GCT II: Prospective Trial for the Diagnosis and Treatment of Children, Adolescents and Young Adults With Intracranial Germ Cell Tumors
Indication:Neoplasms, Germ Cell and Embryonal
Type of study:Phase III
Contact: Renate Sedlak (Study Nurse)
[renate.sedlak@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Olaf Witt (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT01424839
EudraCT: 2009-018072-33 (siehe EU klinisches Studienregister)

SIOP PNET 5 Medulloblastoma (PNET5MB)

(pädiatrisch)
Title:An International Prospective Study on Clinically Standard-risk Medulloblastoma in Children Older Than 3 to 5 Years With Low-risk Biological Profile (PNET 5 MB-LR) or Average-risk Biological Profile (PNET 5 MB-SR)
Indication:Brain Neoplasms Medulloblastoma. patients between the ages of 3 to 5 years and less than 22 years, with ‘standard-risk’ medulloblastoma and a low-risk biological profile.
Type of study:Phase II/III
Contact: Renate Sedlak (Study Nurse)
[renate.sedlak@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Olaf Witt (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02066220
EudraCT: 2011-004868-30 (siehe EU klinisches Studienregister)

Hit-Rez-Register

(pädiatrisch, epidemiologisch)
Title:Hit-Rez-Register
Indication:therapierefraktären, progredienten oder rezidivierten Medulloblastomen, Pineoblastomen, primitiv neuroektodermalen Tumoren des ZNS (ZNS-PNETs) und Ependymomen
Type of study:Phase N/A
Contact: Renate Sedlak (Kontaktperson)
[renate.sedlak@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Olaf Witt (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Retinoblastom Registry

(pädiatrisch, epidemiologisch)
Title:RB-­registry: a clinical registry for prospective data on retinoblastoma epidemiology and clinical course
Indication:Retinoblastom
Type of study:Phase
Contact: Renate Sedlak (Study Nurse)
[renate.sedlak@med.uni-heidelberg.de]
Investigator: Dr. med. Wolfgang Behnisch (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

SIOP-LGG 2004 Registry

(pädiatrisch, epidemiologisch)
Title:Cooperative Multicenter Study for Children and Adolescents With Low Grade Glioma
Indication:Central Nervous System NeoplasmsNeoplasmsNervous System Neoplasms
Type of study:Phase N/A
Contact: Renate Sedlak (Study Nurse)
[renate.sedlak@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Olaf Witt (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT00276640
EudraCT: 2005-005377-29 (siehe EU klinisches Studienregister)

MARCIE

(Schwerionentherapie, radiologisch)
Title:Treatment of Patients with Atypical Meningiomas Simpson Grade 4 and 5 with a Carbon Ion Boost in combination with Postoperative Photon Radiotherapy: A Phase II Trial (MARCIE)
Indication:Atypische Meningeome
Type of study:Phase II
Contact: Renate Haselmann (Study Nurse)
[renate.haselmann@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Leiter klinische Prüfung)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT01166321
EudraCT: 2009-016683-36 (siehe EU klinisches Studienregister)

CYBER-SPACE

(therapeutisch)
Title:Cyberknife Radiosurgery for Patients With Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence - A Prospective Randomized Evaluation of Response and Toxicity
Indication:Neoplasm MetastasisNeoplasms, Second PrimaryBrain Neoplasms
Type of study:Phase II
Contact: Rami El-Shafie (Kontaktperson)
[Rami.Elshafie@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Leiter klinische Prüfung)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03303365
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

EORTC-26081-22086 (CODEL)

Title:Phase III Intergroup Study of Temozolomide Alone Versus Radiotherapy With Concomitant and Adjuvant Temozolomide Versus Radiotherapy With Adjuvant PCV Chemotherapy in Patients With 1p/19q Co-deleted Anaplastic Glioma
Indication:Central Nervous System NeoplasmsNervous System Neoplasms
Type of study:Phase III
Contact: Andrea Dormann (Kontaktperson)
[andrea.dormann@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Wolfgang Wick (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT00887146
EudraCT: 2008-007295-14 (siehe EU klinisches Studienregister)

Encephalon

Title:Whole Brain Radiation Therapy (WBRT) Alone Versus Radiosurgery (SRS) for Patients With 1-10 Brain Metastases From Small Cell Lung Cancer
Indication:Neoplasm Metastasis Neoplasms, Second Primary Brain Neoplasms
Type of study:Phase II
Contact: Rami El-Shafie (Kontaktperson)
[Rami.Elshafie@med.uni-heidelberg.de]
Investigator: Denise Bernhardt (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03297788
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.