Clinical Trials

Neurooncologic Tumors

Recruitment stopped
Ongoing Recruitment

BMS 209-548 (MGMT-Methylated Glioblastoma)

(adjuvant)
Title:A Randomized Phase 2 Single Blind Study of Temozolomide Plus Radiation Therapy Combined With Nivolumab or Placebo in Newly Diagnosed Adult Subjects With MGMT-Methylated (Tumor O6-methylguanine DNA Methyltransferase) Glioblastoma - CheckMate 548: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 548
Indication:Glioblastoma, Brain Neoplasms
Type of study:Phase II
Contact: Andrea Dormann (Kontaktperson)
[andrea.dormann@med.uni-heidelberg.de]
Investigator: PD Dr. med. Antje Wick (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02667587
EudraCT: 2015-004722-34 (siehe EU klinisches Studienregister)

STELLAR Study (OT-15-001)

(adjuvant)
Title:A Randomized Phase 3 Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine With Lomustine Compared to Lomustine Alone in Patients With AA That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy
Indication:Astrocytoma
Type of study:Phase III
Contact: Daniela Hall (Kontaktperson)
[ksc@med.uni-heidelberg.de]
Investigator: PD Dr. med. Antje Wick (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT02796261
EudraCT: 2016-000089-45 (siehe EU klinisches Studienregister)

MARCIE

(Schwerionentherapie, radiologisch)
Title:Treatment of Patients with Atypical Meningiomas Simpson Grade 4 and 5 with a Carbon Ion Boost in combination with Postoperative Photon Radiotherapy: A Phase II Trial (MARCIE)
Indication:Atypische Meningeome
Type of study:Phase II
Contact: Renate Haselmann (Study Nurse)
[renate.haselmann@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Leiter klinische Prüfung)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT01166321
EudraCT: 2009-016683-36 (siehe EU klinisches Studienregister)

CYBER-SPACE

(therapeutisch)
Title:Cyberknife Radiosurgery for Patients With Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence - A Prospective Randomized Evaluation of Response and Toxicity
Indication:Hirnmetastasen, solide Tumoren bei Erwachsenen
Type of study:Phase II
Contact: Dr. med. Rami El-Shafie (Kontaktperson)
[Rami.Elshafie@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Leiter klinische Prüfung)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03303365
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

EORTC 1419

Title:Molecular genetic, host-derived and clinical determinants of long-term survival in glioblastoma
Indication:Glioblastoma
Type of study:Phase N/A
Contact: Sandy Walter (Kontaktperson)
[Sandy.Walter@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Wolfgang Wick (Prüfer)
Trial Register: No trial registry number given.
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

ESTRON

Title:Evaluation of Stereotactic Radiotherapy of the Resection Cavity After Surgery of Brain Metastases Compared to Post-operative Whole-brain Radiotherapy
Indication:Hirnmetastasen bei Erwachsenen
Type of study:Phase II
Contact: Dr. med. Rami El-Shafie (Kontaktperson)
[Rami.Elshafie@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03285932
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Encephalon

Title:Whole Brain Radiation Therapy (WBRT) Alone Versus Radiosurgery (SRS) for Patients With 1-10 Brain Metastases From Small Cell Lung Cancer
Indication:Hirnmetastasen, die von einem kleinzelligen Lungenkarzinom ausgehen
Type of study:Phase II
Contact: Dr. med. Rami El-Shafie (Kontaktperson)
[Rami.Elshafie@med.uni-heidelberg.de]
Investigator: PD Dr. Denise Bernhardt (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03297788
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

NOA-19/ Re-Cog-GBM-l

Title:Test-Retest-Reliabilität und lokalisationsabhängige Sensitivität neurocognitiver Testung bei erstdiagnostizierten Glioblastompatienten.
Indication:Glioblastom-Patienten
Type of study:Phase N/A
Contact: Julia Mattern-Tremper (Study Nurse)
[Julia.Mattern@med.uni-heidelberg.de]
Investigator: Dr. med Christine Jungk (Prüfer)
Trial Register: Die Studie ist beim "DRKS - Deutsches Register Klinischer Studien" registriert. Siehe DRKS00010162
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

Neuro Master Match

Title:Umbrella protocol for phase I/IIa trials of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed glioblastoma without MGMT promoter methylation: NCT Neuro Master Match - N²M² (NOA-20)
Indication:Glioblastom
Type of study:Phase I/II
Contact: Andrea Dormann (Study Nurse)
[andrea.dormann@med.uni-heidelberg.de]
Investigator: PD Dr. med. Antje Wick (Prüfer)
Trial Register: No trial registry number given.
EudraCT: 2015-002752-27 (siehe EU klinisches Studienregister)

TIGER

Title:The use of TTFields for newly diagnosed GBM patients in Germany in routine clinical care – TIGER Study
Indication:Glioblastom
Type of study:Phase N/A
Contact: PD Dr. Denise Bernhardt (Kontaktperson)
[Denise.Bernhardt@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Jürgen Debus (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03258021
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.

VXM01/Avelumab

Title:An Open-label, Phase I/II Multicenter Clinical Trial of VXM01 in Combination With Avelumab in Patients With Progressive Glioblastoma Following Standard Treatment, With or Without Second Surgery
Indication:Rezidivierendes Glioblastom
Type of study:Phase I/II
Contact: Tanja Haut (Study Nurse)
[Tanja.Haut@med.uni-heidelberg.de]
Investigator: Prof. Dr. med. Wolfgang Wick (Prüfer)
Trial Register: Die Studie ist bei den "U.S. National Institutes of Health" (ClinicalTrials.gov) registriert. Siehe NCT03750071
EudraCT: Not stated. Non-interventional studies and studies not controlled by the Medicines Act do not have a EudraCT number.