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Title: Development of Drugs Targeting Purine-Binding Membrane Proteins for Cancer (Immuno) Therapy
Prof. Dr. Christa E. Müller
PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I
University of Bonn, Bonn, Germany
Prof. Dr. Christa Müller is a full professor of pharmaceutical chemistry and a research scientist at the University of Bonn. Her research interests are medicinal chemistry and molecular pharmacology of purine binding membrane proteins (adenosine receptors, P2 purine receptors, adenine receptors and ecto-nucleotidases; lipidactivated and orphan G protein-coupled receptors). Since 2016 she is also elected president of the German Purine Club as well as a member of the Editorial Board of Scientific Reports from the Nature Publishing Group.
Adenosine is an important ubiquitous (patho)physiological modulator. It activates G protein-coupled purine P1 receptors (adenosine receptors, subtypes A1, A2A, A2B, A3) and thereby exerts sedative, anti-convulsive, antidiuretic, negative inotropic & chronotropic, immunosuppressive, anti-inflammatory and angiogenic effects.
In fact, adenosine is one of the most powerful immunosuppressive mediators of the innate immune system. Many cancer cells overexpress ectonucleotidases which convert adenine nucleotides to adenosine producing “a protection shield” of adenosine against attack by immune cells. Therefore, blockade of ectonucleotidases and adenosine receptors has been proposed as a novel strategy in cancer therapy.
Our group has been developing tool compounds and drugs targeting the various subtypes of purine receptors and ectonucleotidases. We are focusing on medicinal chemistry and in vitro pharmacology of purinergic signalling including the development of novel assays, and structure-based approaches.